Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jurupula Ramprasad"'
Autor:
Yanli Liu, Aman Iqbal, Weiguo Li, Zuyao Ni, Yalong Wang, Jurupula Ramprasad, Karan Joshua Abraham, Mengmeng Zhang, Dorothy Yanling Zhao, Su Qin, Peter Loppnau, Honglv Jiang, Xinghua Guo, Peter J. Brown, Xuechu Zhen, Guoqiang Xu, Karim Mekhail, Xingyue Ji, Mark T. Bedford, Jack F. Greenblatt, Jinrong Min
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The SMN protein recognizes symmetric dimethylarginine by its Tudor domain, and SMN deficiency leads to spinal muscular atrophy. Here, Liu et al. discover a small molecule that binds to the SMN Tudor domain and disrupts the interaction between SMN and
Externí odkaz:
https://doaj.org/article/a0e6fffeffbb41e8b6c0ef99920dda4b
Autor:
Xingyue Ji, Chunhua Qiao, Qian Du, Shengchao Zhou, Li-Fang Hu, Miao Liu, Jurupula Ramprasad, Basharat Ali, Yujie Mou
Publikováno v:
The Journal of Organic Chemistry. 85:8352-8359
The hydrolysis of carbonyl sulfide (COS) to form H2S by carbonic anhydrase has been demonstrated to be a viable strategy to deliver H2S in a biological system. Herein, we describe N-dithiasuccinoyl amines as thiol-triggered COS/H2S donors. Notably, t
Autor:
Shengchao, Zhou, Yujie, Mou, Miao, Liu, Qian, Du, Basharat, Ali, Jurupula, Ramprasad, Chunhua, Qiao, Li-Fang, Hu, Xingyue, Ji
Publikováno v:
The Journal of organic chemistry. 85(13)
The hydrolysis of carbonyl sulfide (COS) to form H
Publikováno v:
Journal of Fluorine Chemistry. 183:59-68
In an attempt to develop newer antitubercular and antibacterial agents against the increasing bacterial resistance, we have designed new quinoline–pyrazole analogs ( 8a – u ) following the molecular hybridization approach. The structure of one of
Autor:
Perumal Yogeeswari, Nagabhushana Nayak, Dharmarajan Sriram, Udayakumar Dalimba, Jurupula Ramprasad
Publikováno v:
Chinese Chemical Letters. 27:365-369
This article demonstrates the synthesis, characterization and the study of in vitro antitubercular activities of twenty four new N -(4-(5-aryl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1 H -pyrazol-1-yl)phenyl)-4-amide derivatives ( 8a–x ). The antitubercu
Autor:
Jurupula Ramprasad, Perumal Yogeeswari, Udayakumar Dalimba, Nagabhushana Nayak, Dharmarajan Sriram
Publikováno v:
MedChemComm. 7:338-344
In this paper, we report the facile and efficient one-pot three-component synthesis of 1-((6-phenylimidazo[2,1-b][1,3,4]thiadiazol-5-yl)methylene)-2-(4-phenylthiazol-2-yl)hydrazine derivatives (5a–w) using an ionic liquid, namely 1-butyl-3-methylim
Publikováno v:
European Journal of Medicinal Chemistry. 106:75-84
A new library of phenothiazine and 1,3,4-thiadiazole hybrid derivatives (5a-u) was designed based on the molecular hybridization approach and the molecules were synthesized in excellent yields using a facile single-step chloro-amine coupling reaction
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5540-5545
With the aim of developing promising antitubercular and antibacterial leads, we have designed and synthesized a new series of isonicotinohydrazide based pyrazole derivatives (5a-r). All new derivatives (4a-b and 5a-r) were screened for in vitro antim
Publikováno v:
Journal of Heterocyclic Chemistry. 54:171-182
Autor:
Dharmarajan Sriram, H. S. Santosh Kumar, S. K. Peethambar, Perumal Yogeeswari, Jurupula Ramprasad, Nagabhushana Nayak, Rajeshwara N. Achur, Udayakumar Dalimba
Publikováno v:
Research on Chemical Intermediates. 42:3721-3741
A new series of pyrazole-based 1,2,3-triazole derivatives (6a–x) were synthesized by employing click reaction using a 2:1 mixture of PEG-400 and water as green solvent. The synthesized intermediate and final compounds were characterized by 1H NMR,