Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies

Autor: Jan-Willem C. Alffenaar, Jurriaan E. M. de Steenwinkel, Andreas H. Diacon, Ulrika S. H. Simonsson, Shashikant Srivastava, Sebastian G. Wicha

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

There has been an increased interest in pharmacokinetics and pharmacodynamics (PKPD) of anti-tuberculosis drugs. A better understanding of the relationship between drug exposure, antimicrobial kill and acquired drug resistance is essential not only t

Externí odkaz: https://doaj.org/article/e4542944f8a243b7ad22068ab5e9346d

Delamanid or pretomanid?

Autor: Saskia E. Mudde, Anna M. Upton, Anne Lenaerts, Hannelore I. Bax, Jurriaan E. M. De Steenwinkel

Publikováno v: The Journal of antimicrobial chemotherapy, 77(4), 880-902. Oxford University Press

Given the low treatment success rates of drug-resistant tuberculosis (TB), novel TB drugs are urgently needed. The landscape of TB treatment has changed considerably over the last decade with the approval of three new compounds: bedaquiline, delamani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3537dfa9ede313008067db455edf3f
http://www.scopus.com/inward/record.url?scp=85128159992&partnerID=8YFLogxK

Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data

Autor: Jurriaan E. M. de Steenwinkel, Rami Ayoun Alsoud, Hannelore I. Bax, Saskia E. Mudde, Manisha U. Lotlikar, Aart van der Meijden, Anna M. Upton, Ulrika S. H. Simonsson

Publikováno v: The Journal of infectious diseases, 225(11), 1876-1885. Oxford University Press

Background Given the persistently high global burden of tuberculosis, effective and shorter treatment options are needed. We explored the relationship between relapse and treatment length as well as interregimen differences for 2 novel antituberculos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83548a6b4c01dd3d15020141c91896b1
https://pure.eur.nl/en/publications/df56d81f-b9de-48b0-8768-1143a3afc237

Treatment and Outcome of Culture-Confirmed Mycobacterium marinum Disease

Autor: Louise Hendrikx, Colette L M van Hees, Jurriaan E M de Steenwinkel, Hannelore I Bax, Tom Sprong, Bert Mulder, Arjan Jansz, Arjanne van Griethuysen, Ron Bosboom, Annette Stemerding, Marjolein Koetsier, Marco van Coevorden, Bas C Mourik, Koen D Quint, Alewijn Ott, Dick van Soolingen, Saskia Kuipers, Reinout van Crevel, Jakko van Ingen

Publikováno v: Open Forum Infectious Diseases, 9, 4
Open Forum Infectious Diseases, 9(4):ofac077. Oxford University Press
Open Forum Infectious Diseases, 9(4). OXFORD UNIV PRESS INC
Open Forum Infectious Diseases, 9

Background Mycobacterium marinum is a nontuberculous mycobacterium that causes skin and soft tissue infections. Treatment consists of multiple antibiotics, sometimes combined with surgical debridement. There is little evidence for the choice of antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d316e4978a7a93aa4f88f193360c250

Treatment and Outcome of Culture-Confirmed

Autor: Louise, Hendrikx, Colette L M, van Hees, Jurriaan E M, de Steenwinkel, Hannelore I, Bax, Tom, Sprong, Bert, Mulder, Arjan, Jansz, Arjanne, van Griethuysen, Ron, Bosboom, Annette, Stemerding, Marjolein, Koetsier, Marco, van Coevorden, Bas C, Mourik, Koen D, Quint, Alewijn, Ott, Dick, van Soolingen, Saskia, Kuipers, Reinout, van Crevel, Jakko, van Ingen

Publikováno v: Open forum infectious diseases. 9(4)

We performed a retrospective cohort study of culture-confirmedForty cases ofProlonged and susceptibility-guided treatment results in a 90% cure rate in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f918a4f15a93fd34bd04597dcc3b49cb
https://pubmed.ncbi.nlm.nih.gov/35308482