Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic

Autor: Ilse Bader, Colin Groot, H. Stevie Tan, Jean-Marie A. Milongo, Jurre den Haan, Inge M. W. Verberk, Keir Yong, Julie Orellina, Shannon Campbell, David Wilson, Argonde C. van Harten, Pauline H. B. Kok, Wiesje M. van der Flier, Yolande A. L. Pijnenburg, Frederik Barkhof, Elsmarieke van de Giessen, Charlotte E. Teunissen, Femke H. Bouwman, Rik Ossenkoppele

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-18 (2024)

Abstract Background Alzheimer’s disease (AD) is a common, complex and multifactorial disease that may require screening across multiple routes of referral to enable early detection and subsequent future implementation of tailored interventions. Blo

Externí odkaz: https://doaj.org/article/80e39a0fdb1b42279ca2d571671cea81

Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer’s disease

Autor: Jurre den Haan, Lajos Csinscik, Tom Parker, Ross W. Paterson, Catherine F. Slattery, Alexander Foulkes, Femke H. Bouwman, Frank D. Verbraak, Philip Scheltens, Tunde Peto, Imre Lengyel, Jonathan M. Schott, Sebastian J. Crutch, Timothy J. Shakespeare, Keir X. X. Yong

Publikováno v: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-9 (2019)

Abstract Background Retinal thickness can be measured non-invasively with optical coherence tomography (OCT) and may offer compelling potential as a biomarker for Alzheimer’s disease (AD). Retinal thinning is hypothesized to be a result of retrogra

Externí odkaz: https://doaj.org/article/a174b48a2c1e46119b70577fd801cdb9

Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer’s disease brains: Implications for in-vivo diagnostics

Autor: Jurre den Haan, Tjado H. J. Morrema, Annemieke J. Rozemuller, Femke H. Bouwman, Jeroen J. M. Hoozemans

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-12 (2018)

Abstract The combined fluorescent and Aβ-binding properties of the dietary spice curcumin could yield diagnostic purpose in the search for a non-invasive Aβ-biomarker for Alzheimer’s disease (AD). However, evidence on the binding properties of cu

Externí odkaz: https://doaj.org/article/75dd0001f4e54955828b760001c44bea

Developing retinal biomarkers for the earliest stages of Alzheimer's disease: What we know, what we don't, and how to move forward

Autor: Peter J. Snyder, Jessica Alber, Stuart Sinoff, Delia Cabrera DeBuc, Jurre den Haan, Danielle Goldfarb, Kimberly A. Hernandez, Edmund Arthur, Francesca Cordeiro, Leonardo Provetti-Cunha, Louisa I. Thompson, Stephen Salloway, Gregory P. Van Stavern, Derrick L. Cheng

Publikováno v: Alber, J, Goldfarb, D, Thompson, L I, Arthur, E, Hernandez, K, Cheng, D, DeBuc, D C, Cordeiro, F, Provetti-Cunha, L, den Haan, J, van Stavern, G P, Salloway, S P, Sinoff, S & Snyder, P J 2020, ' Developing retinal biomarkers for the earliest stages of Alzheimer's disease: What we know, what we don't, and how to move forward ', Alzheimers & Dementia, vol. 16, no. 1, pp. 229-243 . https://doi.org/10.1002/alz.12006

The last decade has seen a substantial increase in research focused on the identification, development, and validation of diagnostic and prognostic retinal biomarkers for Alzheimer's disease (AD). Sensitive retinal biomarkers may be advantageous beca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953ec6216b3621ef5055431437b551bb
https://doi.org/10.1002/alz.12006

The Amsterdam Experience: Insights from 7 years of retinal biomarker experience in a tertiary memory clinic

Autor: Jurre den Haan

Publikováno v: Alzheimer's & Dementia. 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01ad21c6dbef3fe3319f45f0c9b3628f
https://doi.org/10.1002/alz.055240