Dipole moments of scorpion toxins direct the interaction towards small- or large-conductance Ca2+-activated K+ channels

Autor: Valérie Frémont, Jurphaas Van Rietschoten, Hervé Darbon, Marcel Crest, Marie-France Martin-Eauclaire, Eric Blanc, Maurice Gola

Publikováno v: Letters in Peptide Science. 4:305-312

Ca2+-activated K+ channels consist of a large family of membrane proteins, among which two groups have been characterized by electrophysiological criteria, the small conductance (SK) and the large conductance (BK) Ca2+-activated K+ channels. Scorpion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::801664d32c39605ee9386dbebdb1881e
https://doi.org/10.1007/bf02442894

V3 loop-derived multibranched peptides as inhibitors of HIV infection in CD4+ and CD4− cells

Autor: Jean-Marc Sabatier, Kamel Mabrouk, Jurphaas Van Rietschoten, Nouara Yahi, Hervé Rochat, Jacques Fantini

Publikováno v: Perspectives in Drug Discovery and Design. 5:243-250

The V3 loop is one of the variable domains of the HIV-1 surface envelope glycoprotein gp120 that mainly generates isolate-specific neutralizing antibodies. These anti-V3 antibodies presumably interfere with the function of the V3 loop that is thought

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46f0894ebb60bdfb96ef5323f8d76665
https://doi.org/10.1007/bf02174019

Evaluation of multibranched peptides as inhibitors of HIV infection

Autor: Jurphaas Van Rietschoten, Kamel Mabrouk, Nouara Yahi, Hervé Rochat, Jean-Marc Sabatier, Facques Fantini

Publikováno v: Letters in Peptide Science. 1:17-24

Synthetic polymeric constructions (SPCs) containing the consensus sequence of the HIV-1 surface envelope gycoprotein gp120 V3 loop (GPGRAF) block the fusion between HIV-1- and HIV-2-infected cells and CD4+-uninfected lymphocytes. By testing the activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::120ca7cfe0a67484d5d5615aa2ec384a
https://doi.org/10.1007/bf00132758

Specificity of anti-P25 antibodies produced against whole HIV-1 particles or soluble forms of the protein

Autor: Kamel Mabrouk, Jean Claude Gluckman, Hervé Rochat, Abdelaziz Benjouad, Jurphaas Van Rietschoten, Elmostasfa Bahraoui

Publikováno v: Molecular Immunology. 29:1309-1318

Specificity of anti-p25 antibodies produced against either whole Human Immunodeficiency Virus type 1 (HIV-1) particles in humans and chimpanzees, or against soluble forms of the protein in chimpanzees and rabbits was analyzed by ELISA using a panel o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a16495cf4fc0315235d0a60eef619b
https://doi.org/10.1016/0161-5890(92)90167-v

Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels

Autor: Ziad Fajloun, Hervé Rochat, Kamel Mabrouk, Besma Jouirou, Amor Mosbah, Mohamed El Ayeb, Jean-Marc Sabatier, Sarrah Ben M’Barek, Michel De Waard, Guy Lippens, Stephan Grissmer, Violeta Visan, Jurphaas Van Rietschoten, Christiane Devaux

Publikováno v: Biochemical Journal
Biochemical Journal, 2004, 377 (1), pp.37-49. ⟨10.1042/BJ20030977⟩
Biochemical Journal, Portland Press, 2004, 377 (1), pp.37-49. ⟨10.1042/BJ20030977⟩

International audience; CoTX1 (cobatoxin 1) is a 32-residue toxin with three disulphide bridges that has been isolated from the venom of the Mexican scorpion Centruroides noxius Hoffmann. Here we report the chemical synthesis, disulphide bridge organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e51795b2c50b8c36267051f6fe4fb7
https://hal-riip.archives-ouvertes.fr/pasteur-02020551