Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jurjen W Westra"'
Autor:
Suzanne E Peterson, Jurjen W Westra, Stevens K Rehen, Holly Young, Diane M Bushman, Christine M Paczkowski, Yun C Yung, Candace L Lynch, Ha T Tran, Kyle S Nickey, Yu-Chieh Wang, Louise C Laurent, Jeanne F Loring, Melissa K Carpenter, Jerold Chun
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23018 (2011)
Human pluripotent stem cell (hPSC) lines have been considered to be homogeneously euploid. Here we report that normal hPSC--including induced pluripotent--lines are karyotypic mosaics of euploid cells intermixed with many cells showing non-clonal ane
Externí odkaz:
https://doaj.org/article/d2ba257e2f15481f86a4b1b0c20a9ba5
Autor:
Ewan Hunter, Ronald McCord, Aroul S. Ramadass, Jayne Green, Jurjen W. Westra, Kirsten Mundt, Alexandre Akoulitchev
Publikováno v:
Translational Medicine Communications, Vol 5, Iss 1, Pp 1-13 (2020)
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is a heterogenous blood cancer, but can be broadly classified into two main subtypes, germinal center B-cell-like (GCB) and activated B-cell-like (ABC). GCB and ABC subtypes have very differen
Externí odkaz:
https://doaj.org/article/dd1dbd6712ab427ab6b8e4a4c9f5aa08
Autor:
Ewan Hunter, Mehrnoush Dezfouli, Christina Koutsothanasi, Adam Wilson, Francisco C. Santos, Matthew Salter, Jurjen W. Westra, Ryan Powell, Ann Dring, Benedict Egan, Matthew Parnall, Morgan Thacker, Jayne Green, Aroul Ramadass, Serene Ng, Chun Ren Lim, Cheah Soon Keat, Ang Tick Suan, Rakesh Raman, Ho Kean Fatt, Fabian Lee Wei Luen, Thomas Guiel, Robert Heaton, Jedd Levine, Alexandre Akoulitchev
Unprecedented advantages in cancer treatment with immune checkpoint inhibitors (ICI) remain limited to a subset of patients. Systemic analyses of the regulatory 3D genome architecture linked to individual epigenetics and immunogenetic controls associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4d567116c27bf302f074e5decd9f94b
https://doi.org/10.1101/2021.12.21.21268094
https://doi.org/10.1101/2021.12.21.21268094
Autor:
Alain Sewer, Jennifer Park, Brian P. Frushour, Jurjen W. Westra, Marja Talikka, Manuel C. Peitsch, Ty M. Thomson, Florian Martin, Vincenzo Belcastro, Stephan Gebel, Dmitry Vasilyev, Julia Hoeng, Walter K. Schlage
Publikováno v:
Toxicology and Applied Pharmacology. 272:863-878
Exposure to biologically active substances such as therapeutic drugs or environmental toxicants can impact biological systems at various levels, affecting individual molecules, signaling pathways, and overall cellular processes. The ability to derive
Autor:
Carole Mathis, Dirk Weisensee, Julia Hoeng, Jurjen W. Westra, Ty M. Thomson, Manuel C. Peitsch, Rosemarie B. Lichtner, Michael Peck, Vy Hoang, Emilija Veljkovic, Ben Wong, Marja Talikka, Walter K. Schlage, Renée Deehan, Arnd Hengstermann, Stephan Gebel
Publikováno v:
Bioinformatics and Biology Insights, Vol 2013, Iss 7, Pp 167-192 (2013)
Bioinformatics and Biology Insights
Bioinformatics and Biology Insights, Vol 7 (2013)
Bioinformatics and Biology Insights
Bioinformatics and Biology Insights, Vol 7 (2013)
Exposure to environmental stressors such as cigarette smoke (CS) elicits a variety of biological responses in humans, including the induction of inflammatory responses. These responses are especially pronounced in the lung, where pulmonary cells sit
Publikováno v:
Neurodegenerative Diseases. 6:221-229
Alzheimer’s disease (AD) is characterized by extensive neuronal death in distinct brain regions, including the frontal cortex and hippocampus, although the specific mechanisms of neuronal degeneration in AD remain a topic of intense scientific purs
Autor:
William Hayes, Jurjen W. Westra, Stéphanie Boué, Alain Sewer, Emilija Veljkovic, Julia Hoeng, Brett Fields, Manuel C. Peitsch, Sam Ansari, Jennifer Park, Renee Deehan Kenney, Marja Talikka, Florian Martin, Anselmo Di Fabio, Walter K. Schlage
Publikováno v:
Database: The Journal of Biological Databases and Curation
With the wealth of publications and data available, powerful and transparent computational approaches are required to represent measured data and scientific knowledge in a computable and searchable format. We developed a set of biological network mod
Publikováno v:
Neurodegenerative Diseases. 8:38-40
Autor:
Arnd Hengstermann, Manuel C. Peitsch, Marja Talikka, Emilija Veljkovic, Jennifer Park, Brian P. Frushour, Stephan Gebel, Michael Peck, Ignacio Gonzalez-Suarez, Jurjen W. Westra, Stéphanie Boué, Julia Hoeng, Gary Toedter, Renée Deehan, Ulrike Kogel, Walter K. Schlage
Publikováno v:
Journal of Clinical Toxicology.
We have recently developed methodologies to quantify the biological impact of exposure to environmental toxicants via the use of computable network models and network scoring methods. In this study, we extend our collection of lung pathophysiology sp
Autor:
Jurjen W. Westra, Vy Hoang, Marja Talikka, Emilija Veljkovic, Michael Peck, Walter K. Schlage, Arnd Hengstermann, Julia Hoeng, Carole Mathis, Renée Deehan, Stephan Gebel, Brian P. Frushour, Manuel C. Peitsch, Rosemarie B. Lichtner
Publikováno v:
Bioinformatics and Biology Insights, Vol 7 (2013)
Bioinformatics and Biology Insights, Vol 2013, Iss 7, Pp 97-117 (2013)
Bioinformatics and Biology Insights
Bioinformatics and Biology Insights, Vol 2013, Iss 7, Pp 97-117 (2013)
Bioinformatics and Biology Insights
Towards the development of a systems biology-based risk assessment approach for environmental toxicants, including tobacco products in a systems toxicology setting such as the “21st Century Toxicology”, we are building a series of computable biol