Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jurij Dolenšek"'
Autor:
Marko Šterk, Yaowen Zhang, Viljem Pohorec, Eva Paradiž Leitgeb, Jurij Dolenšek, Richard K P Benninger, Andraž Stožer, Vira Kravets, Marko Gosak
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 5, p e1012130 (2024)
Within the islets of Langerhans, beta cells orchestrate synchronized insulin secretion, a pivotal aspect of metabolic homeostasis. Despite the inherent heterogeneity and multimodal activity of individual cells, intercellular coupling acts as a homoge
Externí odkaz:
https://doaj.org/article/8347d06d07734c829efed481627ebe78
Autor:
Saška Lipovšek, Jurij Dolenšek, Barbara Dariš, Ismael Valladolid-Acebes, Tanja Vajs, Gerd Leitinger, Andraž Stožer, Maša Skelin Klemen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Mouse models of diet-induced type 2 diabetes mellitus provide powerful tools for studying the structural and physiological changes that are related to the disease progression. In this study, diabetic-like glucose dysregulation was induced in mice by
Externí odkaz:
https://doaj.org/article/d63ce1fc53084f619142e10ecca7589b
Autor:
Eva Paradiž Leitgeb, Jasmina Kerčmar, Lidija Križančić Bombek, Vilijem Pohorec, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Gosak, Jurij Dolenšek, Andraž Stožer
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
Tight control of beta cell stimulus-secretion coupling is crucial for maintaining homeostasis of energy-rich nutrients. While glucose serves as a primary regulator of this process, incretins augment beta cell function, partly by enhancing cytosolic [
Externí odkaz:
https://doaj.org/article/a6e99579252845b08b22b2247a8b5f5b
Autor:
Maša Skelin Klemen, Jurij Dolenšek, Lidija Križančić Bombek, Viljem Pohorec, Marko Gosak, Marjan Slak Rupnik, Andraž Stožer
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Beta cells couple stimulation by glucose with insulin secretion and impairments in this coupling play a central role in diabetes mellitus. Cyclic adenosine monophosphate (cAMP) amplifies stimulus-secretion coupling via protein kinase A and guanine nu
Externí odkaz:
https://doaj.org/article/6297194e5ee7452c9c230234b0a65125
Autor:
Andraž Stožer, Marko Šterk, Eva Paradiž Leitgeb, Rene Markovič, Maša Skelin Klemen, Cara E. Ellis, Lidija Križančić Bombek, Jurij Dolenšek, Patrick E. MacDonald, Marko Gosak
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Islets of Langerhans are multicellular microorgans located in the pancreas that play a central role in whole-body energy homeostasis. Through secretion of insulin and other hormones they regulate postprandial storage and interprandial usage of energy
Externí odkaz:
https://doaj.org/article/109af4155a4f429eb54fcff8d94f2722
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Although mice are a very instrumental model in islet beta cell research, possible phenotypic differences between strains and substrains are largely neglected in the scientific community. In this study, we show important phenotypic differences in beta
Externí odkaz:
https://doaj.org/article/2ac5319e3d0a447cb4b02069efc85606
Autor:
Urška Marolt, Eva Paradiž Leitgeb, Viljem Pohorec, Saška Lipovšek, Viktória Venglovecz, Eleonóra Gál, Attila Ébert, István Menyhárt, Stojan Potrč, Marko Gosak, Jurij Dolenšek, Andraž Stožer
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
The physiology and pathophysiology of the exocrine pancreas are in close connection to changes in intra-cellular Ca2+ concentration. Most of our knowledge is based on in vitro experiments on acinar cells or acini enzymatically isolated from their sur
Externí odkaz:
https://doaj.org/article/67d403fb13634e8fbe745fc33fe3e7c3
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Anatomical proximity and functional correlations between the exocrine and endocrine pancreas warrant reciprocal effects between the two parts. Inflammatory diseases of the exocrine pancreas, such as acute or chronic pancreatitis, or the presence of c
Externí odkaz:
https://doaj.org/article/0fa2a1ae45b24c4abab7bf5f64687d2f
Autor:
Jan Zmazek, Maša Skelin Klemen, Rene Markovič, Jurij Dolenšek, Marko Marhl, Andraž Stožer, Marko Gosak
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Beta cells within the pancreatic islets of Langerhans respond to stimulation with coherent oscillations of membrane potential and intracellular calcium concentration that presumably drive the pulsatile exocytosis of insulin. Their rhythmic activity i
Externí odkaz:
https://doaj.org/article/64e744cd74a54c4ea00483b0c057a675
Autor:
Vladimir Grubelnik, Rene Markovič, Saška Lipovšek, Gerd Leitinger, Marko Gosak, Jurij Dolenšek, Ismael Valladolid-Acebes, Per-Olof Berggren, Andraž Stožer, Matjaž Perc, Marko Marhl
Publikováno v:
Royal Society Open Science, Vol 7, Iss 1 (2020)
Type 2 diabetes mellitus (T2DM) has been associated with insulin resistance and the failure of β-cells to produce and secrete enough insulin as the disease progresses. However, clinical treatments based solely on insulin secretion and action have ha
Externí odkaz:
https://doaj.org/article/454729f8eaaa4b82a6578669f44af8c2