TREM1 activation of myeloid cells promotes antitumor immunity.

Autor: Juric V; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Mayes E; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Binnewies M; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Lee T; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Canaday P; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Pollack JL; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Rudolph J; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Du X; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Liu VM; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Dash S; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Palmer R; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Jahchan NS; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Ramoth ÅJ; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Lacayo S; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Mankikar S; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Norng M; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Brassell C; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Pal A; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Chan C; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Lu E; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Sriram V; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Streuli M; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Krummel MF; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA., Baker KP; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA., Liang L; Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San Francisco, CA 94080, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Aug 30; Vol. 15 (711), pp. eadd9990. Date of Electronic Publication: 2023 Aug 30.

Normal plasmalogen levels are maintained in tissues from mice with hepatocyte-specific deletion in peroxin 5.

Autor: Werner ER; Institute of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria. Electronic address: ernst.r.werner@i-med.ac.at., Swinkels D; Laboratory of Cell Metabolism, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49 box 823, 3000 Leuven, Belgium. Electronic address: danielle.swinkels@kuleuven.be., Juric V; Institute of Human Genetics, Medical University of Innsbruck, Peter-Mayr-Str. 1, 6020 Innsbruck, Austria. Electronic address: viktorija.juric@i-med.ac.at., Dorninger F; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria. Electronic address: fabian.dorninger@meduniwien.ac.at., Baes M; Laboratory of Cell Metabolism, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49 box 823, 3000 Leuven, Belgium. Electronic address: myriam.baes@kuleuven.be., Keller MA; Institute of Human Genetics, Medical University of Innsbruck, Peter-Mayr-Str. 1, 6020 Innsbruck, Austria. Electronic address: markus.keller@i-med.ac.at., Berger J; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria. Electronic address: johannes.berger@meduniwien.ac.at., Watschinger K; Institute of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria. Electronic address: katrin.watschinger@i-med.ac.at.

Publikováno v: Brain research bulletin [Brain Res Bull] 2023 Feb; Vol. 193, pp. 158-165. Date of Electronic Publication: 2022 Dec 28.

Targeting TREM2 on tumor-associated macrophages enhances immunotherapy.

Autor: Binnewies M; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Pollack JL; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Rudolph J; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Dash S; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Abushawish M; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Lee T; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Jahchan NS; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Canaday P; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Lu E; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Norng M; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Mankikar S; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Liu VM; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Du X; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Chen A; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Mehta R; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Palmer R; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Juric V; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Liang L; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Baker KP; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA. Electronic address: kbaker@pionyrtx.com., Reyno L; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Krummel MF; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: matthew.krummel@ucsf.edu., Streuli M; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA., Sriram V; Pionyr Immunotherapeutics, South San Francisco, CA 94080, USA. Electronic address: vesriram@gmail.com.

Publikováno v: Cell reports [Cell Rep] 2021 Oct 19; Vol. 37 (3), pp. 109844.

Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation.

Autor: Juric V; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, Ireland., Hudson L; Department of Surgery, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin, Ireland., Fay J; Department of Pathology, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Beaumont Hospital, Dublin, Ireland., Richards CE; Department of Molecular Medicine, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Beaumont Hospital, Dublin, Ireland., Jahns H; Pathobiology Section, School of Veterinary Medicine, University College Dublin, Dublin, Ireland., Verreault M; INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau, Paris, France., Bielle F; INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau, Paris, France.; AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Paris, France., Idbaih A; INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau, Paris, France.; AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Paris, France., Lamfers MLM; Department of Neurosurgery, Brain Tumor Center, Erasmus MC, Rotterdam, the Netherlands., Hopkins AM; Department of Surgery, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin, Ireland., Rehm M; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.; Stuttgart Research Center Systems Biology, University of Stuttgart, Stuttgart, Germany., Murphy BM; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, Ireland. bronamurphy@rcsi.com.

Publikováno v: Cell death & disease [Cell Death Dis] 2021 Aug 03; Vol. 12 (8), pp. 763. Date of Electronic Publication: 2021 Aug 03.

Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM.

Autor: Juric V; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin 2, Ireland., Düssmann H; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin 2, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin 2, Ireland., Lamfers MLM; Brain Tumor Center, Department of Neurosurgery, Erasmus MC, 3015 CN Rotterdam, The Netherlands., Prehn JHM; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin 2, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin 2, Ireland., Rehm M; Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany.; Stuttgart Research Center Systems Biology, University of Stuttgart, 70569 Stuttgart, Germany., Murphy BM; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin 2, Ireland.

Publikováno v: Cells [Cells] 2021 May 12; Vol. 10 (5). Date of Electronic Publication: 2021 May 12.