Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jurian Schuijers"'
Autor:
Jurian Schuijers, John Colonnese Manteiga, Abraham Selby Weintraub, Daniel Sindt Day, Alicia Viridiana Zamudio, Denes Hnisz, Tong Ihn Lee, Richard Allen Young
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 349-360 (2018)
Summary: Transcriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the 2.8 Mb TAD where MYC resides. We find t
Externí odkaz:
https://doaj.org/article/550f4fbbf19649f2abe725687a117283
Publikováno v:
Stem Cell Reports, Vol 3, Iss 2, Pp 234-241 (2014)
The epithelium of the small intestine is the most rapidly self-renewing tissue in mammals. We previously demonstrated the existence of a long-lived pool of cycling stem cells defined by Lgr5 expression at the bottom of intestinal crypts. An Lgr5-eGFP
Externí odkaz:
https://doaj.org/article/14816697cf94499b965e9956184987f9
Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles.
Autor:
Michal Mokry, Pantelis Hatzis, Ewart de Bruijn, Jan Koster, Rogier Versteeg, Jurian Schuijers, Marc van de Wetering, Victor Guryev, Hans Clevers, Edwin Cuppen
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15092 (2010)
Immunoprecipitated crosslinked protein-DNA fragments typically range in size from several hundred to several thousand base pairs, with a significant part of chromatin being much longer than the optimal length for next-generation sequencing (NGS) proc
Externí odkaz:
https://doaj.org/article/68b3e00bcb334a91b78ef370c1399ac7
Publikováno v:
Advances in experimental medicine and biology. 1390
The nuclear receptor superfamily is a group of transcriptional regulators that orchestrate multiple vital processes such as inflammation, metabolism, and cell proliferation. In recent years, it has become clear that some nuclear receptors form conden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e10b8a85b295d57e35e13e3c495976b8
https://pubmed.ncbi.nlm.nih.gov/36107323
https://pubmed.ncbi.nlm.nih.gov/36107323
Autor:
Xin Tang, Gary LeRoy, Alicia V. Zamudio, Alessandra Dall’Agnese, Richard A. Young, Emile Wogram, Jurian Schuijers, Nancy M. Hannett, Jonathan E. Henninger, Tenzin Lungjangwa, Tong Ihn Lee, Jesse M. Platt, Eliot L. Coffey, Ozgur Oksuz, X. Shawn Liu, Styliani Markoulaki, Charles H. Li, Lena K. Afeyan, Rudolf Jaenisch, Devon S. Svoboda
Publikováno v:
Nature
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing1–3. Mutations in the MECP2 gene cause the progressive neurodevelopmental disorder Ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f51fc72bdd6c60ff1b8c95fcbf6cd08
https://doi.org/10.1038/s41586-020-2574-4
https://doi.org/10.1038/s41586-020-2574-4
Autor:
Richard A. Young, John C. Manteiga, Jurian Schuijers, Tong Ihn Lee, Daniel S. Day, Alicia V. Zamudio, Denes Hnisz, Abraham S. Weintraub
Publikováno v:
Elsevier
Cell Reports, Vol 23, Iss 2, Pp 349-360 (2018)
Cell reports
Cell Reports
Cell Reports, Vol 23, Iss 2, Pp 349-360 (2018)
Cell reports
Cell Reports
Transcriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the 2.8 Mb TAD where MYC resides. We find that these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857b631454618044d4f4b3881d28e1f9
https://doi.org/10.1016/j.celrep.2018.03.056
https://doi.org/10.1016/j.celrep.2018.03.056
Autor:
Brian J. Abraham, Benjamin R. Sabari, Alicia V. Zamudio, Dylan J. Taatjes, Nancy M. Hannett, Jonathan E. Henninger, Tim-Michael Decker, Ozgur Oksuz, Ann Boija, Ibrahim I Cisse, Eliot L. Coffey, Susana Wilson Hawken, Isaac A. Klein, Tong I. Lee, Jan-Hendrik Spille, Lena K. Afeyan, Charles H. Li, Alessandra Dall’Agnese, John C. Manteiga, Richard A. Young, Jurian Schuijers
Publikováno v:
Mol Cell
PMC
PMC
The gene expression programs that define the identity of each cell are controlled by master transcription factors (TFs) that bind cell-type-specific enhancers, as well as signaling factors, which bring extracellular stimuli to these enhancers. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7185548d26f43e122d2f61bcdefc827
https://pubmed.ncbi.nlm.nih.gov/31563432
https://pubmed.ncbi.nlm.nih.gov/31563432
Autor:
Richard A. Young, Phillip A. Sharp, Eliot L. Coffey, Jurian Schuijers, Isaac A. Klein, Benjamin R. Sabari, Arup K. Chakraborty, Alicia V. Zamudio, Ann Boija, Nancy M. Hannett, Krishna Shrinivas
Publikováno v:
PMC
Mol Cell
Mol Cell
© 2019 Elsevier Inc. Enhancers are DNA elements that are bound by transcription factors (TFs), which recruit coactivators and the transcriptional machinery to genes. Phase-separated condensates of TFs and coactivators have been implicated in assembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8498dcf46632b98a3f16d366e54b9074
https://doi.org/10.1101/495606
https://doi.org/10.1101/495606
Autor:
Tong Ihn Lee, John C. Manteiga, Alicia V. Zamudio, Charli B. Fant, Richard A. Young, Dylan J. Taatjes, Jurian Schuijers, Ann Boija, Nancy M. Hannett, Lena K. Afeyan, Benjamin R. Sabari, Eliot L. Coffey, Alessandra Dall’Agnese, Jenna K. Rimel, Isaac A. Klein, Charles H. Li, Krishna Shrinivas, Yang Eric Guo, Brian J. Abraham
Publikováno v:
PMC
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ADs effect gene activation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5565c69aec0f6124b264f1f66f88ae3f
https://pubmed.ncbi.nlm.nih.gov/30550782
https://pubmed.ncbi.nlm.nih.gov/30550782
Autor:
Krishna Shrinivas, Ibrahim I Cisse, Robert G. Roeder, Eliot L. Coffey, Daniel S. Day, Arup K. Chakraborty, Phillip A. Sharp, Isaac A. Klein, Benjamin R. Sabari, Yang Eric Guo, Richard A. Young, Brian J. Abraham, Jurian Schuijers, Sohail Malik, John C. Manteiga, Alessandra Dall’Agnese, Tong Ihn Lee, Eliza Vasile, Charles H. Li, Denes Hnisz, Alicia V. Zamudio, Nancy M. Hannett, Ann Boija
Publikováno v:
PMC
Science
Science
Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity. Here we demonstrate that the SE-enriched transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ece1611d16023f81ebabd029091f53
https://orcid.org/0000-0002-8764-1809
https://orcid.org/0000-0002-8764-1809