Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Juri Y Fukuda"'
Autor:
Angie Wadsworth, Lany Ruslim, Bhushan Samant, Dennis S. Hom, Linda Chen, Hongbing Zhang, Juri Y Fukuda, Mei-Chuan Ko, Anna Liao, Stellanie Simmonds, Karla P. Zeitz, Wes Zmolek, Raymond A. Chavez, Michael P. Bova, Balazs G. Szoke, Mark Dreyer, Albert W. Garofalo, Annika B. Malmberg, Eduardo R. Butelman, Ryan Holcomb, Jon E. Hawkinson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:619-630
The bradykinin B(1) receptor plays a critical role in chronic pain and inflammation, although efforts to demonstrate efficacy of receptor antagonists have been hampered by species-dependent potency differences, metabolic instability, and low oral exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd5c128d96318ca657dbc995c3d83a7
https://doi.org/10.1124/jpet.107.120352
https://doi.org/10.1124/jpet.107.120352
Autor:
Bhushan Samant, Mark Shoemaker, Michael Krimm, Elizabeth Messersmith, Brent Welch, John-Michael Sauer, Linda Chen, Michael S. Dappen, Wenxian Mao, Zhenmei Liao, Ted Yednock, Jenifer L. Smith, Carrol Henschel, Nancy G. Wehner, Lilibeth Dofiles, Ian Gallager, Linda Mutter, Michael A. Pleiss, Mark Dreyer, David A. Quincy, Andrei W. Konradi, Hongbin Zhang, Christopher M. Semko, Kassandra Inez Rossiter, Eric Petersen, George Shopp, Juri Y Fukuda, Brian Wipke, Christopher Vandevert, Frederique Bard, Judevin Lugar, Ying-Zi Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(15)
A series of potent α4β1/α4β7 integrin inhibitors is reported, including an inhibitor 12d with remarkable oral exposure and efficacy in rat models of rheumatoid arthritis and Crohn's disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66768022ffa01968eeb4ffde33c72d33
https://pubmed.ncbi.nlm.nih.gov/23777782
https://pubmed.ncbi.nlm.nih.gov/23777782
Autor:
Tony C Luu, Yong Zhou, Todd W. Miller, Asaad S. Nematalla, Chris Liang, James Wei, Ji-Yu Chu, Juri Y Fukuda, Anand Sistla, Sheri Shirazian, Flora Tang, Hui Chen, Jean Cui, Xueyan Wang, Li Sun, Cho Tang
Publikováno v:
Journal of medicinal chemistry. 46(7)
To improve the antitumor properties and optimize the pharmaceutical properties including solubility and protein binding of indolin-2-ones, a number of different basic and weakly basic analogues were designed and synthesized. 5-[5-Fluoro-2-oxo-1,2-dih
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb1cb03e168b36d5d0975d65a682974
https://pubmed.ncbi.nlm.nih.gov/12646019
https://pubmed.ncbi.nlm.nih.gov/12646019