Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jurgen Wess"'
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1893 (2008)
Adult mice communicate by emitting ultrasonic vocalizations (USVs) during the appetitive phases of sexual behavior. However, little is known about the genes important in controlling call production. Here, we study the induction and regulation of USVs
Externí odkaz:
https://doaj.org/article/9d3c1689cce747e2a136661f457fd26e
Autor:
Jurgen Wess, Celine Valant, Andrew B. Tobin, David Thal, Roy D. Schwarz, Neil M. Nathanson, Ernst Mutschler, Fred Mitchelson, Chris Langmead, Günter Lambrecht, Heinz J. Kilbinger, Rudolf Hammer, Christian C. Felder, Frederick Ehlert, Richard M. Eglen, Arthur Christopoulos, R.A. John Challiss, Noel J. Buckley, David A. Brown, Sophie Bradley, Nigel J. M. Birdsall
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [53]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in
Autor:
Liu Liu, Kimberley El, Diptadip Dattaroy, Luiz F. Barella, Yinghong Cui, Sarah M. Gray, Carla Guedikian, Min Chen, Lee S. Weinstein, Emily Knuth, Erli Jin, Matthew J. Merrins, Jeffrey Roman, Klaus H. Kaestner, Nicolai Doliba, Jonathan E. Campbell, Jürgen Wess
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Glucagon, a hormone released from pancreatic α-cells, is critical for maintaining euglycemia and plays a key role in the pathophysiology of diabetes. To stimulate the development of new classes of therapeutic agents targeting glucagon relea
Externí odkaz:
https://doaj.org/article/351c5d2d342f41a0a55bf933e3b5e318
Autor:
Liu Liu, Kimberley EI, Diptadip Dattaroy, Luiz F. Barella, Yinghong Cui, Sarah M. Gray, Carla Guedikian, Min Chen, Lee S. Weinstein, Emily Knuth, Erli Jin, Matthew J. Merrins, Jeffrey Roman, Klaus H. Kaestner, Nicolai Doliba, Jonathan E. Campbell, Jürgen Wess
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/90b54496c01f4db795d6cee6a571c9d1
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101866- (2024)
Objective: G-protein-coupled receptor (GPCR) kinases (GRKs) abrogate GPCR signaling by promoting receptor desensitization and internalization. Accumulating evidence suggests that GRK2 represents an important regulator of GPCR-mediated effects on syst
Externí odkaz:
https://doaj.org/article/e0aabeb834e942d886dfb235e5257e13
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M
Autor:
Robert W, Gould, Michael D, Grannan, Barak W, Gunter, Jacob, Ball, Michael, Bubser, Thomas M, Bridges, Jurgen, Wess, Michael W, Wood, Nicholas J, Brandon, Mark E, Duggan, Colleen M, Niswender, Craig W, Lindsley, P Jeffrey, Conn, Carrie K, Jones
Publikováno v:
Neuropharmacology. 128
Although selective activation of the M(1) muscarinic acetylcholine receptor (mAChR) subtype has been shown to improve cognitive function in animal models of neuropsychiatric disorders, recent evidence suggests that enhancing M(4) mAChR function can a
Autor:
Takefumi Kimura, Sai P. Pydi, Lei Wang, Dhanush Haspula, Yinghong Cui, Huiyan Lu, Gabriele M. König, Evi Kostenis, Gregory R. Steinberg, Oksana Gavrilova, Jürgen Wess
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Obesity impairs regulation of adipocyte lipolysis, which contributes towards development of insulin resistance. Here the authors report that adipocyte Gq signaling functions as a regulator of lipolysis and systemic glucose and lipid homeostasis in mi
Externí odkaz:
https://doaj.org/article/f0d1158d61ee4a5a901478e2a9b74e39
Autor:
Jaroslawna Meister, Derek B. J. Bone, Jonas R. Knudsen, Luiz F. Barella, Thomas J. Velenosi, Dmitry Akhmedov, Regina J. Lee, Amanda H. Cohen, Oksana Gavrilova, Yinghong Cui, Gerard Karsenty, Min Chen, Lee S. Weinstein, Maximilian Kleinert, Rebecca Berdeaux, Thomas E. Jensen, Erik A. Richter, Jürgen Wess
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this study, the authors demonstrated that agents targeting skeletal muscle metabolism by modulating β2-adrenergic receptor-dependent signaling may prove beneficial as novel antidiabetic drugs.
Externí odkaz:
https://doaj.org/article/59a46724f573486ab78cf2fe37925d04
Autor:
Michael Grannan, Michael Bubser, Thomas Bridges, Robert Gould, Ditte Dencker Thorbek, J Daniels, Meredith Noetzel, Colleen Niswender, Mark Duggan, Nicholas Brandon, John Dunlop, Michael Wood, Jurgen Wess, Craig Lindsley, P Conn, Carrie Jones
Publikováno v:
The FASEB Journal. 28
Many symptoms in schizophrenia are attributed to alternations in normal glutamatergic signaling in the prefrontal cortex (PFC). In preclinical studies, psychotomimetic agents like the N-methyl-D-aspartate receptor antagonist MK-801 induce enhanced sp
Autor:
Jurgen Wess
Publikováno v:
Journal of Diabetes & Metabolism.