Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jurgen Scheller"'
Autor:
Zheheng Ding, Xueqing Liu, Hongyan Jiang, Jianfeng Zhao, Sebastian Temme, Pascal Bouvain, Christina Alter, Puyan Rafii, Jürgen Scheller, Ulrich Flögel, Hongtao Zhu, Zhaoping Ding
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Histological analysis with 2,3,5-triphenyltetrazolium chloride (TTC) staining is the most frequently used tool to detect myocardial ischemia/reperfusion injury. However, its practicality is often challenged by poor image quality in gross his
Externí odkaz:
https://doaj.org/article/92fb827015d244dcb175ccb140c693d9
Autor:
Linda Große-Segerath, Paula Follert, Kristina Behnke, Julia Ettich, Tobias Buschmann, Philip Kirschner, Sonja Hartwig, Stefan Lehr, Mortimer Korf-Klingebiel, Daniel Eberhard, Nadja Lehwald-Tywuschik, Hadi Al-Hasani, Wolfram Trudo Knoefel, Stefan Heinrich, Bodo Levkau, Kai C. Wollert, Jürgen Scheller, Eckhard Lammert
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood flow initiates liver growth in mice by vasodilation and mechanically-triggered release of angiocrine signals. Here, we use mass spectrometry to identify
Externí odkaz:
https://doaj.org/article/b17a84beedaf4e2c841ebb07a602c275
Autor:
Nils Hampel, Jacqueline Georgy, Mehrnaz Mehrabipour, Alexander Lang, Isabell Lehmkuhl, Jürgen Scheller, Mohammad R. Ahmadian, Doreen M. Floss, Roland P. Piekorz
Publikováno v:
FEBS Open Bio, Vol 13, Iss 12, Pp 2187-2199 (2023)
SIRT4, together with SIRT3 and SIRT5, comprises the mitochondrially localized subgroup of sirtuins. SIRT4 regulates mitochondrial bioenergetics, dynamics (mitochondrial fusion), and quality control (mitophagy) via its NAD+‐dependent enzymatic activ
Externí odkaz:
https://doaj.org/article/3f16df6f448a42b7bf36896ed4596877
Autor:
Saeideh Nakhaei-Rad, Fereshteh Haghighi, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Karolin Kleemann, Anne Schänzer, Andrea Borchardt, Andreas Hahn, Sebastian Kötter, Denny Schanze, Ruchika Anand, Florian Funk, Annette Vera Kronenbitter, Jürgen Scheller, Roland P. Piekorz, Andreas S. Reichert, Marianne Volleth, Matthew J. Wolf, Ion Cristian Cirstea, Bruce D. Gelb, Marco Tartaglia, Joachim P. Schmitt, Martina Krüger, Ingo Kutschka, Lukas Cyganek, Martin Zenker, George Kensah, Mohammad R. Ahmadian
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract Noonan syndrome (NS), the most common among RASopathies, is caused by germline variants in genes encoding components of the RAS-MAPK pathway. Distinct variants, including the recurrent Ser257Leu substitution in RAF1, are associated with seve
Externí odkaz:
https://doaj.org/article/334fbffc3d50486090984e565b31f40f
Autor:
Puyan Rafii, Christiane Seibel, Hendrik T. Weitz, Julia Ettich, Anna Rita Minafra, Patrick Petzsch, Alexander Lang, Doreen M. Floss, Kristina Behnke, Karl Köhrer, Jens M. Moll, Jürgen Scheller
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory
Externí odkaz:
https://doaj.org/article/4e5af694c75a4cba811637e4b68d6f48
Autor:
Christina Alter, Anne-Sophie Henseler, Christoph Owenier, Julia Hesse, Zhaoping Ding, Tobias Lautwein, Jasmin Bahr, Sikander Hayat, Rafael Kramann, Eva Kostenis, Jürgen Scheller, Jürgen Schrader
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Plasma IL-6 is elevated after myocardial infarction (MI) and is associated with increased morbidity and mortality. Which cardiac cell type preferentially contributes to IL-6 expression and how its production is regulated are largely unknown. Here, we
Externí odkaz:
https://doaj.org/article/ba21c702fe434f01823d8dcc73bc160c
Autor:
Anna Rita Minafra, Alexandra Chadt, Puyan Rafii, Hadi Al-Hasani, Kristina Behnke, Jürgen Scheller
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
High level of interleukin 6 (IL-6), released by adipocytes in an obesity-induced, low grade inflammation state, is a regulator of insulin resistance and glucose tolerance. IL-6 has also regenerative, anti-inflammatory and anti-diabetogenic functions,
Externí odkaz:
https://doaj.org/article/8bd209574140489582ca3c78868f9e4c
Autor:
Nele Zoellner, Noémi Coesfeld, Frederik Henry De Vos, Jennifer Denter, Haifeng C. Xu, Elena Zimmer, Birgit Knebel, Hadi Al-Hasani, Sofie Mossner, Philipp A. Lang, Doreen M. Floss, Jürgen Scheller
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Type I interferons (IFNs) are potent inhibitors of viral replication. Here, we reformatted the natural murine and human type I interferon-α/β receptors IFNAR1 and IFNAR2 into fully synthetic biological switches. The transmembrane and intracellular
Externí odkaz:
https://doaj.org/article/a844187356564f8ba83cf36bff594e71
Autor:
Ricardo F Frausto, Gareth Denyer, Jurgen Scheller, Stefan Rose-John, Brendan J Jenkins, Matthias Ernst, Iain L Campbell
Publikováno v:
The Journal of Immunology. 182:38.17-38.17
Astrocytes derived from Y757F mutant mice defective in gp130-SHP2/SOCS3 signaling were investigated into their ability to respond to IL-6. Compared with WT astrocytes, Y757F astrocytes treated with hyper-IL6, had higher and more sustained activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0abd76b7cca5f48de4d73c3f6c870e7d
https://doi.org/10.4049/jimmunol.182.supp.38.17
https://doi.org/10.4049/jimmunol.182.supp.38.17
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102471- (2021)
Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerizat
Externí odkaz:
https://doaj.org/article/c625d64df0cf43129faab621de8ab571