Meningococcal factor H binding protein fHbpd184 polymorphism influences clinical course of meningococcal meningitis.

Autor: Jurgen R Piet, Matthijs C Brouwer, Rachel Exley, Stijn van der Veen, Diederik van de Beek, Arie van der Ende

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47973 (2012)

Factor H Binding protein (fHbp) is an important meningococcal virulence factor, enabling the meningococcus to evade the complement system, and a main target for vaccination. Recently, the structure of fHBP complexed with factor H (fH) was published.

Externí odkaz: https://doaj.org/article/bdd8407743ef44a8a1cd7edcfc9012cb

Meningococcal Two-Partner Secretion Systems and Their Association with Outcome in Patients with Meningitis

Autor: Sandra Bovenkerk, Stephen D. Bentley, Arie van der Ende, Sadeeq ur Rahman, Peter van Ulsen, Jurgen R. Piet, Diederik van de Beek

Publikováno v: Infection and Immunity, 84(9), 2534-2540. American Society for Microbiology
Piet, J R, van Ulsen, P, Ur Rahman, S, Bovenkerk, S, Bentley, S D, van de Beek, S & van der Ende, A 2016, ' Meningococcal two-partner secretion systems and their association with outcome in patients with meningitis. ', Infection and Immunity, vol. 84, no. 9, pp. 2534-2540 . https://doi.org/10.1128/IAI.00160-16
Infection and immunity, 84(9), 2534-2540. American Society for Microbiology

Two-partner secretion (TPS) systems export large TpsA proteins to the surface and extracellular milieu. In meningococci, three different TPS systems exist, and of these, TPS system 2 (TPS2) and TPS3 can be detected by the host's immune system. We eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d504e992b8329b44ae5d1b58e6def5
https://pubmed.ncbi.nlm.nih.gov/27324486

Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis: a prospective cohort study

Autor: Sebastiaan G. B. Heckenberg, Lodewijk Spanjaard, Diederik van de Beek, Martijn Weisfelt, Matthijs C. Brouwer, Jan de Gans, Jurgen R. Piet, Arie van der Ende

Publikováno v: Medicine, 87(4), 185-192. Lippincott Williams and Wilkins

Meningococcal meningitis remains a life-threatening disease. Neisseria meningitidis is the leading cause of meningitis and septicemia in young adults and is a major cause of endemic bacterial meningitis worldwide. The Meningitis Cohort Study was a Du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557142b87e5fd9366127aaaa56efc227
https://pure.amc.nl/en/publications/clinical-features-outcome-and-meningococcal-genotype-in-258-adults-with-meningococcal-meningitis-a-prospective-cohort-study(8c313fdc-4c8d-4cee-84aa-0f591ebe7d86).html

Genome sequence of Neisseria meningitidis serogroup B strain H44/76

Autor: A. H. C. van Kampen, Jurgen R. Piet, Yvonne Pannekoek, D. van de Beek, R. A. G. Huis in 't Veld, Frank Baas, A. van der Ende, B D C van Schaik

Publikováno v: Journal of bacteriology, 193(9), 2371-2372. American Society for Microbiology

Neisseria meningitidis is an obligate human pathogen. While it is a frequent commensal of the upper respiratory tract, in some individuals the bacterium spreads to the bloodstream, causing meningitis and/or sepsis, which are serious conditions with h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b6a877af5ae1d7c34f62bf9ea054e3
https://doi.org/10.1128/jb.01331-10