Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jurgen Langenhorst"'
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 11, Pp 2310-2322 (2023)
Abstract The Mayo Clinical Score is used in clinical trials to describe the clinical status of patients with ulcerative colitis (UC). It comprises four subscores: rectal bleeding (RB), stool frequency (SF), physician's global assessment, and endoscop
Externí odkaz:
https://doaj.org/article/107fa89c02734a2698e4c04b30c5afe5
Autor:
Logan Brooks, Michael Dolton, Jurgen Langenhorst, Kenta Yoshida, Yi Ting (Kayla) Lien, Vikram Malhi, Chunze Li, Pablo Perez‐Moreno, John Bond, Ya‐Chi Chen, Jiajie Yu
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 5, Pp 823-834 (2023)
Abstract Concentration‐QTc (C‐QTc) analysis has become a common approach for evaluating proarrhythmic risk and delayed cardiac repolarization of oncology drug candidates. Significant heart rate (HR) change has been associated with certain classes
Externí odkaz:
https://doaj.org/article/309c621807754593873a9d5a3f1647b8
Autor:
Nastya Kassir, Rui Zhu, Anita Moein, Jurgen Langenhorst, Jakob Ribbing, Rong Zhang, Meina T. Tang, Young S. Oh, Wenhui Zhang
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 9, Pp 1234-1243 (2022)
Abstract Etrolizumab is an IgG1‐humanized monoclonal anti‐β7 integrin antibody. Phase III trials with induction and/or maintenance phases were conducted in patients with moderately‐to‐severely active ulcerative colitis (UC) who were either p
Externí odkaz:
https://doaj.org/article/8678c1be491e4d60aa7f5d8efa301631
Autor:
Coco de Koning, Julie-Anne Gabelich, Jurgen Langenhorst, Rick Admiraal, Jurgen Kuball, Jaap Jan Boelens, Stefan Nierkens
Publikováno v:
Blood Advances, Vol 2, Iss 5, Pp 565-574 (2018)
Abstract: Residual antithymocyte globulin (ATG; Thymoglobulin) exposure after allogeneic hematopoietic (stem) cell transplantation (HCT) delays CD4+ T-cell immune reconstitution (CD4+ IR), subsequently increasing morbidity and mortality. This effect
Externí odkaz:
https://doaj.org/article/39414988be6f4fef8073cbd663270820
Autor:
Fei Tang, Jurgen Langenhorst, Steve Dang, Nastya Kassir, Ryan Owen, Barbara Purdon, Mats O. Magnusson, Rong Deng
Publikováno v:
The Journal of Clinical Pharmacology. 63:197-209
The pharmacokinetics (PK) of tenecteplase in patients with acute ischemic stroke has not been extensively studied. This study aimed to describe PK characteristics of tenecteplase in patients with acute myocardial infarction (AMI) using a population P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529d7bb05b39040e68555b1170ba2b62
https://doi.org/10.1002/jcph.2164
https://doi.org/10.1002/jcph.2164
Autor:
Claudia Meyer, Ines Dierick, Glenn Gauderat, Jurgen Langenhorst, Céline Sarr, Emilie Leroux, Marylore Chenel, Sylvain Fouliard, Paul Passier
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:310-320
During development of a drug, the requirement of evaluating the proarrhythmic risk and delayed repolarization needs to be fulfilled. Would it be possible to create an alternative to a thorough QT (TQT) study or is there a need to perform a dedicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3311bdd36e03f62fd392eb75c6d5697c
https://doi.org/10.1002/cpt.2596
https://doi.org/10.1002/cpt.2596
Autor:
Jaap Jan Boelens, Alwin D. R. Huitema, Stefan Nierkens, Thomas P. C. Dorlo, Moniek de Witte, Charlotte van Kesteren, Erik M. van Maarseveen, Jurgen Langenhorst
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 5, Pp 272-281 (2020)
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 5, Pp 272-281 (2020)
Optimal fludarabine exposure has been associated with improved treatment outcome in allogeneic hematopoietic cell transplantation, suggesting potential benefit of individualized dosing. A randomized controlled trial (RCT) comparing alternative fludar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a54462b4bd1c70b65d9f40809ca6ee7
http://europepmc.org/articles/PMC7239337
http://europepmc.org/articles/PMC7239337
Autor:
Erik M. van Maarseveen, Antoine C. G. Egberts, Charlotte van Kesteren, Alwin D. R. Huitema, Jaap Jan Boelens, Jürgen Kuball, Jill Boss, Arief Lalmohamed, Jurgen Langenhorst
Publikováno v:
British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology, 86(8), 1499. NLM (Medline)
British Journal of Clinical Pharmacology, 86(8), 1499. NLM (Medline)
Aim To develop a semi-mechanistic model, based on glutathione depletion and predict a previously identified intra-individual reduction in busulfan clearance to aid in more precise dosing. Methods Busulfan concentration data, measured as part of regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5016b81eac9727f7c897640518e09d5c
https://doi.org/10.1111/bcp.14256
https://doi.org/10.1111/bcp.14256
Autor:
Jaap-Jan Boelens, Reinier A P Raijmakers, J. Kuball, Thomas P. C. Dorlo, Caroline A. Lindemans, M. A. de Witte, Alwin D. R. Huitema, Stefan Nierkens, Jurgen Langenhorst, C. van Kesteren, A. van Rhenen, E. M. van Maarseveen, Marc Bierings
Publikováno v:
Blood Advances, 3(14), 2179. The American Society of Hematology
Fludarabine is the most frequently used agent in conditioning regimens for allogeneic hematopoietic cell transplantation (HCT). Body surface area–based dosing leads to highly variable fludarabine exposure. We studied the relation between fludarabin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414399ab78eabf6b3a327484140fd985
https://doi.org/10.1182/bloodadvances.2018029421
https://doi.org/10.1182/bloodadvances.2018029421
Autor:
Andromachi Scaradavou, Maria Cancio, Celina L. Szanto, Mirjam E. Belderbos, Elizabeth Klein, Wouter J.W. Kollen, Farid Boulad, Nancy A. Kernan, Dorine Bresters, Marc Bierings, Stefan Nierkens, Kevin J. Curran, Barbara Spitzer, Coco de Koning, Jurgen Langenhorst, Jaap Jan Boelens, Birgitta Versluijs, Caroline A. Lindemans, Susan E. Prockop, Alwin D. R. Huitema, Ichelle van Roessel, Richard J. O'Reilly
Publikováno v:
Blood
Acute graft-versus-host-Disease (aGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). We previously showed that early CD4+ T-cell immune reconstitution (IR; CD4+ IR) predicts survival after HCT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5555c041f4a96722046831f6ef4a6558
https://europepmc.org/articles/PMC7986048/
https://europepmc.org/articles/PMC7986048/
