Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Jurgen A Marteijn"'
Autor:
Diana A. Llerena Schiffmacher, Shun-Hsiao Lee, Katarzyna W. Kliza, Arjan F. Theil, Masaki Akita, Angela Helfricht, Karel Bezstarosti, Camila Gonzalo-Hansen, Haico van Attikum, Matty Verlaan-de Vries, Alfred C. O. Vertegaal, Jan H. J. Hoeijmakers, Jurgen A. Marteijn, Hannes Lans, Jeroen A. A. Demmers, Michiel Vermeulen, Titia K. Sixma, Tomoo Ogi, Wim Vermeulen, Alex Pines
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to c
Externí odkaz:
https://doaj.org/article/ae22f3558ad948a0bf15ffe295f5314c
Autor:
Alba Muniesa-Vargas, Carlota Davó-Martínez, Cristina Ribeiro-Silva, Melanie van der Woude, Karen L. Thijssen, Ben Haspels, David Häckes, Ülkem U. Kaynak, Roland Kanaar, Jurgen A. Marteijn, Arjan F. Theil, Maayke M. P. Kuijten, Wim Vermeulen, Hannes Lans
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Congenital nucleotide excision repair (NER) deficiency gives rise to several cancer-prone and/or progeroid disorders. It is not understood how defects in the same DNA repair pathway cause different disease features and severity. Here, we sho
Externí odkaz:
https://doaj.org/article/93db3bf48b4e441887ae6a50279dcc97
Autor:
Arjan F Theil, Julie Nonnekens, Barbara Steurer, Pierre-Olivier Mari, Jan de Wit, Charlène Lemaitre, Jurgen A Marteijn, Anja Raams, Alex Maas, Marcel Vermeij, Jeroen Essers, Jan H J Hoeijmakers, Giuseppina Giglia-Mari, Wim Vermeulen
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003431 (2013)
The ten-subunit transcription factor IIH (TFIIH) plays a crucial role in transcription and nucleotide excision repair (NER). Inactivating mutations in the smallest 8-kDa TFB5/TTDA subunit cause the neurodevelopmental progeroid repair syndrome trichot
Externí odkaz:
https://doaj.org/article/7d60226eb215453780f9c39c8c311231
Autor:
Hannes Lans, Jurgen A Marteijn, Björn Schumacher, Jan H J Hoeijmakers, Gert Jansen, Wim Vermeulen
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000941 (2010)
Nucleotide Excision Repair (NER), which removes a variety of helix-distorting lesions from DNA, is initiated by two distinct DNA damage-sensing mechanisms. Transcription Coupled Repair (TCR) removes damage from the active strand of transcribed genes
Externí odkaz:
https://doaj.org/article/d9a950f67d414f6e8125c1515b650106
Autor:
Diana van den Heuvel, Cornelia G. Spruijt, Román González-Prieto, Angela Kragten, Michelle T. Paulsen, Di Zhou, Haoyu Wu, Katja Apelt, Yana van der Weegen, Kevin Yang, Madelon Dijk, Lucia Daxinger, Jurgen A. Marteijn, Alfred C. O. Vertegaal, Mats Ljungman, Michiel Vermeulen, Martijn S. Luijsterburg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The transcription-coupled repair pathway removes transcription-blocking DNA lesions, but how transcription is restored following DNA repair is not clear. Here the authors reveal that the PAF1 complex, while dispensable for the repair process, restore
Externí odkaz:
https://doaj.org/article/9746b9cc6bd9439f9dadbc1fe139cf31
Autor:
Cristina Ribeiro-Silva, Mariangela Sabatella, Angela Helfricht, Jurgen A. Marteijn, Arjan F. Theil, Wim Vermeulen, Hannes Lans
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA damage sensors DDB2 and XPC are fundamental factors to initiate global genome nucleotide excision repair and protect DNA from mutagenesis. Here the authors reveal that ubiquitin and TFIIH-stimulated DDB2 dissociation promotes DNA damage handover
Externí odkaz:
https://doaj.org/article/22a70086ef524db897815d6000e52c4e
Autor:
Ying Zhang, Imke K. Mandemaker, Syota Matsumoto, Oded Foreman, Christopher P. Holland, Whitney R. Lloyd, Kaoru Sugasawa, Wim Vermeulen, Jurgen A. Marteijn, Paul J. Galardy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Nucleotide excision repair (NER) is a pathway involved in the repair of a variety of potentially mutagenic lesions that distort the DNA double helix. The ubiquitin E3-ligase complex UV-DDB is required for the recognition and repair of UV-induced cycl
Externí odkaz:
https://doaj.org/article/17a9c7aa9a754973ad2586ee1f0bfdee
Autor:
Helga B. Landsverk, Lise E. Sandquist, Lilli T.E. Bay, Barbara Steurer, Coen Campsteijn, Ole J.B. Landsverk, Jurgen A. Marteijn, Eva Petermann, Laura Trinkle-Mulcahy, Randi G. Syljuåsen
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108469- (2020)
Summary: Transcription-replication (T-R) conflicts cause replication stress and loss of genome integrity. However, the transcription-related processes that restrain such conflicts are poorly understood. Here, we demonstrate that the RNA polymerase II
Externí odkaz:
https://doaj.org/article/d88cff54f29d4bef9a68867c7e0033c3
Autor:
Cristina Ribeiro-Silva, Özge Z. Aydin, Raquel Mesquita-Ribeiro, Jana Slyskova, Angela Helfricht, Jurgen A. Marteijn, Jan H. J. Hoeijmakers, Hannes Lans, Wim Vermeulen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
SWI/SNF genes are commonly found to be mutated in different cancers. Here the authors report that the remodelers BRM and BRG1 are necessary for efficient nucleotide excision repair by promoting the expression of TFIIH subunit GTF2H1.
Externí odkaz:
https://doaj.org/article/eb220f4c08794f88ad5354ea35208f77
Autor:
Camila Gonzalo Hansen, Barbara Steurer, Roel C. Janssens, Di Zhou, Marjolein van Sluis, Hannes Lans, Jurgen A. Marteijn
Faithful transcription of eukaryotic genes by RNA polymerase II (Pol II) is essential for proper cell function. Nevertheless, the integrity of the DNA template of Pol II is continuously challenged by different sources of DNA damage, such as UV-light,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe7c6942307ee50f041d7ec3a13a255
https://doi.org/10.1101/2023.05.17.541110
https://doi.org/10.1101/2023.05.17.541110
