Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Jurgen, Sygusch"'
Autor:
Wei Li, Amira Yazidi, Amitkumar N. Pandya, Pooja Hegde, Weiwei Tong, Vinicius Calado Nogueira de Moura, E. Jeffrey North, Jurgen Sygusch, Mary Jackson
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Nontuberculous mycobacterial (NTM) pulmonary infections are emerging as a global health problem and pose a threat to susceptible individuals with structural or functional lung conditions such as cystic fibrosis, chronic obstructive pulmonary disease
Externí odkaz:
https://doaj.org/article/21b36001d95a492eabf158383e276b34
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Neutral endopeptidase (neprilysin; NEP) is a proteinase that cleaves a wide variety of peptides and has been implicated in Alzheimer's disease, cardiovascular conditions, arthritis and other inflammatory diseases. The structure of the soluble extrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6f51bede6098baf9ad5c59b8f9c4e9
https://doi.org/10.1107/s2053230x19006046
https://doi.org/10.1107/s2053230x19006046
Autor:
Lucien Fabre, Abigail T. Ntreh, Amira Yazidi, Inga V. Leus, Sudipta Bhattacharyya, Helen I. Zgurskaya, Jurgen Sygusch, Jon W. Weeks, Jakob Ruickoldt, Isabelle Rouiller
Publikováno v:
Structure
The structure of the TriABC inner membrane component of the triclosan/SDS-specific efflux pump from Pseudomonas aeruginosa was determined by cryoelectron microscopy to 4.5 A resolution. The complete structure of the inner membrane transporter TriC of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dd9afdb27849fca1eacc2ff7c48251
https://europepmc.org/articles/PMC7935746/
https://europepmc.org/articles/PMC7935746/
Publikováno v:
Journal of Medicinal Chemistry. 61:10558-10572
The glycolytic enzyme aldolase is an emerging drug target in diseases such as cancer and protozoan infections which are dependent on a hyperglycolytic phenotype to synthesize adenosine 5'-triphosphate and metabolic precursors for biomass production.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e80c3c1898ed765a4046c5ae82431ed
https://doi.org/10.1021/acs.jmedchem.8b01000
https://doi.org/10.1021/acs.jmedchem.8b01000
Autor:
Paul W. Heron, Jurgen Sygusch
Publikováno v:
Journal of Biological Chemistry. 292:19849-19860
Fructose-1,6-bisphosphate (FBP) aldolase, a glycolytic enzyme, catalyzes the reversible and stereospecific aldol addition of dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde 3-phosphate (d-G3P) by an unresolved mechanism. To afford insight into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda62b85b43c91a54375c8ea133024cf
https://doi.org/10.1074/jbc.m117.811034
https://doi.org/10.1074/jbc.m117.811034
Autor:
James G. Omichinski, Dean E. Wilcox, Jurgen Sygusch, Haytham M. Wahba, Ahmed Mansour, Michael J. Stevenson
Publikováno v:
Journal of the American Chemical Society. 139:910-921
The organomercurial lyase MerB has the unique ability to cleave carbon–Hg bonds, and structural studies indicate that three residues in the active site (C96, D99, and C159 in E. coli MerB) play important roles in the carbon–Hg bond cleavage. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f36019fc1ff62a404ab6e78e8c4affc
https://doi.org/10.1021/jacs.6b11327
https://doi.org/10.1021/jacs.6b11327
Autor:
Agnieszka Gizak, Janusz Wiśniewski, Paul W. Heron, Dariusz Rakus, Jurgen Sygusch, Piotr Mamczur
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 10, Pp 1-16 (2019)
Cell Death and Disease, Vol 10, Iss 10, Pp 1-16 (2019)
Muscle fructose-1,6-bisphosphate aldolase (ALDOA) is among the most abundant glycolytic enzymes in all cancer cells. Here, we show that the enzyme plays a previously unknown and critical role in a cancer cell survival. Simultaneous inhibition of ALDO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e226e9b831eedc62b9750e904fc3a10
http://europepmc.org/articles/PMC6763475
http://europepmc.org/articles/PMC6763475
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Type IV secretion systems are multiprotein complexes that mediate the translocation of macromolecules across the bacterial cell envelope. In Helicobacter pylori a type IV secretion system encoded by the cag pathogenicity island encodes 27 proteins an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a2d9b38152d97a9994a4a1b26afa21
https://doi.org/10.1038/s41598-019-42876-6
https://doi.org/10.1038/s41598-019-42876-6
Type IV secretion systems are membrane-bound multiprotein complexes that mediate the translocation of macromolecules across the bacterial cell envelope. In Helicobacter pylori a type IV secretion system is encoded by the cag pathogenicity island that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f3f235848faec0ac53a16f358b3abe
Autor:
Jing Hu, Jurgen Sygusch, Mathieu Coinçon, Janey M. Fang, Caroline Alfieri, Valérie Leblond, Jerome E. Tanner
Publikováno v:
Journal of Virology. 89:4932-4941
Epstein-Barr virus (EBV) is the etiologic agent of infectious mononucleosis and the root cause of B-cell lymphoproliferative disease in individuals with a weakened immune system, as well as a principal cofactor in nasopharyngeal carcinoma, various ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8003db597e929a085eab2a1f1cea2718
https://doi.org/10.1128/jvi.03269-14
https://doi.org/10.1128/jvi.03269-14