Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Jurgen, Joossens"'
Autor:
Hannah Ceuleers, Nikita Hanning, Michelle De bruyn, Joris G De Man, Heiko U De Schepper, Qian Li, Liansheng Liu, Steven Abrams, Annemieke Smet, Jurgen Joossens, Koen Augustyns, Ingrid De Meester, Pankaj J Pasricha, Benedicte Y De Winter
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Serine proteases are believed to play a key role in the origin of abdominal pain in IBD and IBS. We previously demonstrated a reduction of visceral pain in a post-inflammatory IBS rat model after a single intraperitoneal or intracolonic a
Externí odkaz:
https://doaj.org/article/2e982d8ea77b4cd0af0421bfcbe928ff
Autor:
Hanne Van Spaendonk, Hannah Ceuleers, Annemieke Smet, Maya Berg, Jurgen Joossens, Pieter Van der Veken, Sven M. Francque, Anne-Marie Lambeir, Joris G. De Man, Ingrid De Meester, Koen Augustyns, Benedicte Y. De Winter
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: A protease/antiprotease disbalance is observed in inflammatory bowel diseases (IBD). We therefore studied the effect of the novel serine protease inhibitor UAMC-00050 on intestinal inflammation and permeability in a chronic colitis T cell
Externí odkaz:
https://doaj.org/article/21b5fe8dc7624ef18c29d312443ee481
Autor:
Nikita Hanning, Michelle De bruyn, Hannah Ceuleers, Tim Boogaerts, Maya Berg, Annemieke Smet, Heiko U. De Schepper, Jurgen Joossens, Alexander L. N. van Nuijs, Joris G. De Man, Koen Augustyns, Ingrid De Meester, Benedicte Y. De Winter
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 811 (2021)
Dysregulation of the protease–antiprotease balance in the gastrointestinal tract has been suggested as a mechanism underlying visceral hypersensitivity in conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). We ai
Externí odkaz:
https://doaj.org/article/bfb9756fc6404ddbabce04e440fd583d
Autor:
Sebastiaan Van De Vijver, Stephan Missault, Jeroen Van Soom, Pieter Van Der Veken, Koen Augustyns, Jurgen Joossens, Stefanie Dedeurwaerdere, Michele Giugliano
Publikováno v:
PeerJ, Vol 7, p e6796 (2019)
Neurons are embedded in an extracellular matrix (ECM), which functions both as a scaffold and as a regulator of neuronal function. The ECM is in turn dynamically altered through the action of serine proteases, which break down its constituents. This
Externí odkaz:
https://doaj.org/article/7fadd74250a346db96f04537f7b04515
Autor:
Chandra S. Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus W. C. Verbeek, Ryabtsova Oksana, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, René Houtman, Winnok H. De Vos, Jurgen Joossens, Pieter Van Der Veken, Koen Augustyns, Xaveer Van Ostade, Annemie Bogaerts, Hans De Winter, Wim Vanden Berghe
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC liga
Externí odkaz:
https://doaj.org/article/f904b8d98f0241f082ac224164430591
Autor:
Jurgen Joossens, Pieter Van der Veken, Nathalie Cools, Guy Caljon, Peter Delputte, Filip Kiekens, Anne-Marie Lambeir, Adrienn Baán, Erik Fransen, Carlos Moreno-Cinos, Koen Augustyns, Lieve Moons, Louis Maes, Ellen Lanckacker, Paul Cos, Kim Lemmens, Ingrid De Meester, Cedric Joossen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific reports
Scientific Reports
Scientific reports
Scientific Reports
Dry eye syndrome (DES), a multifactorial disorder which leads to ocular discomfort, visual disturbance and tear film instability, has a rising prevalence and limited treatment options. In this study, a newly developed trypsin-like serine protease inh
Autor:
Hannah Ceuleers, Nikita Hanning, Michelle De bruyn, Joris G De Man, Heiko U De Schepper, Qian Li, Liansheng Liu, Steven Abrams, Annemieke Smet, Jurgen Joossens, Koen Augustyns, Ingrid De Meester, Pankaj J Pasricha, Benedicte Y De Winter
Publikováno v:
Frontiers in pharmacology
Background: Serine proteases are believed to play a key role in the origin of abdominal pain in IBD and IBS. We previously demonstrated a reduction of visceral pain in a post-inflammatory IBS rat model after a single intraperitoneal or intracolonic a
Autor:
Laura Reinhardt, Cristina D. Cruz, Gesa Witt, Päivi Tammela, Siham Benramdane, Heike Brötz-Oesterhelt, Elisa Sassetti, Carlos Moreno-Cinos, Mathias Winterhalter, Jurgen Joossens, Irene G. Salado, Philip Gribbon, Koen Augustyns, Björn Windshügel, Pieter Van der Veken
Publikováno v:
Journal of Medicinal Chemistry
Journal of medicinal chemistry
Journal of medicinal chemistry
Increased Gram-negative bacteria resistance to antibiotics is becoming a global problem, and new classes of antibiotics with novel mechanisms of action are required. The caseinolytic protease subunit P (ClpP) is a serine protease conserved among bact
Autor:
Jurgen Joossens, Annemieke Smet, Ingrid De Meester, Hannah Ceuleers, Nikita Hanning, Maya Berg, Joris G. De Man, Tim Boogaerts, Heiko U. De Schepper, Alexander L.N. van Nuijs, Koen Augustyns, Michelle De bruyn, Benedicte Y. De Winter
Publikováno v:
Pharmaceutics
Pharmaceutics, Vol 13, Iss 811, p 811 (2021)
Volume 13
Issue 6
Pharmaceutics, Vol 13, Iss 811, p 811 (2021)
Volume 13
Issue 6
Dysregulation of the protease–antiprotease balance in the gastrointestinal tract has been suggested as a mechanism underlying visceral hypersensitivity in conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). We ai
Autor:
Jurgen Joossens, Joris G. De Man, Hannah Ceuleers, Sven Francque, Jelena Heirbaut, Ingrid De Meester, Jean-Pierre Timmermans, Koen Augustyns, Benedicte Y. De Winter, Nikita Hanning, Samuel Van Remoortel, Anne-Marie Lambeir, Pieter Van der Veken, Michelle De bruyn
Publikováno v:
British Journal of Pharmacology. 175:3516-3533
Background and purpose Serine proteases have been re suggested as important mediators of visceral pain. We investigated their effect by using newly developed serine protease inhibitors with a well-characterized inhibitory profile in a rat model of po