Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Jurga Laurencikiene"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Salt-inducible kinase 2 (SIK2) is highly expressed in white adipocytes, but downregulated in individuals with obesity and insulin resistance. These conditions are often associated with a low-grade inflammation in adipose tissue. We and other
Externí odkaz:
https://doaj.org/article/7df1de0e02e042cbae75eb99432fa9bd
Autor:
Narmadha Subramanian, Kaisa Hofwimmer, Beatriz Tavira, Lucas Massier, Daniel P Andersson, Peter Arner, Jurga Laurencikiene
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Aim Obesity is linked to cardiometabolic diseases, however non-obese individuals are also at risk for type 2 diabetes (T2D) and cardiovascular disease (CVD). White adipose tissue (WAT) is known to play a role in both T2D and CVD, but the con
Externí odkaz:
https://doaj.org/article/046a15b794304227b1bec7ebfb0d45cf
Autor:
Lucas Massier, Jutta Jalkanen, Merve Elmastas, Jiawei Zhong, Tongtong Wang, Pamela A. Nono Nankam, Scott Frendo-Cumbo, Jesper Bäckdahl, Narmadha Subramanian, Takuya Sekine, Alastair G. Kerr, Ben T. P. Tseng, Jurga Laurencikiene, Marcus Buggert, Magda Lourda, Karolina Kublickiene, Nayanika Bhalla, Alma Andersson, Armand Valsesia, Arne Astrup, Ellen E. Blaak, Patrik L. Ståhl, Nathalie Viguerie, Dominique Langin, Christian Wolfrum, Matthias Blüher, Mikael Rydén, Niklas Mejhert
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Single-cell studies of human white adipose tissue (WAT) provide insights into the specialized cell types in the tissue. Here the authors combine publicly available and newly generated high-resolution and bulk transcriptomic results from multiple huma
Externí odkaz:
https://doaj.org/article/403c68977c1d4356b1c8f7dee3850e20
Autor:
Narmadha Subramanian, Kaisa Hofwimmer, Beatriz Tavira, Lucas Massier, Daniel P. Andersson, Peter Arner, Jurga Laurencikiene
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/f6ea70c24f874ed78378a8684475b6f2
Autor:
Narmadha Subramanian, Beatriz Tavira, Kaisa Hofwimmer, Beate Gutsmann, Lucas Massier, Julie Abildgaard, Anders Juul, Mikael Rydén, Peter Arner, Jurga Laurencikiene
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundObesity-associated metabolic complications display sexual dimorphism and can be impacted by cytokines. We previously showed that interleukin-10 (IL-10) was upregulated in white adipose tissue (WAT) of obese women with type 2 diabetes (T2D).
Externí odkaz:
https://doaj.org/article/981085db62a14ba8a673bc2208419650
Autor:
Julia Sánchez-Ceinos, Rocío Guzmán-Ruiz, Oriol Alberto Rangel-Zúñiga, Jaime López-Alcalá, Elena Moreno-Caño, Mercedes Del Río-Moreno, Juan Luis Romero-Cabrera, Pablo Pérez-Martínez, Elsa Maymo-Masip, Joan Vendrell, Sonia Fernández-Veledo, José Manuel Fernández-Real, Jurga Laurencikiene, Mikael Rydén, Antonio Membrives, Raul M Luque, José López-Miranda, María M Malagón
Publikováno v:
eLife, Vol 10 (2021)
Preadipocytes are crucial for healthy adipose tissue expansion. Preadipocyte differentiation is altered in obese individuals, which has been proposed to contribute to obesity-associated metabolic disturbances. Here, we aimed at identifying the pathog
Externí odkaz:
https://doaj.org/article/af1e565ee14b40e49f3a99c51d6ad84c
Autor:
Juan R. Acosta, Simon Joost, Kasper Karlsson, Anna Ehrlund, Xidan Li, Myriam Aouadi, Maria Kasper, Peter Arner, Mikael Rydén, Jurga Laurencikiene
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-6 (2017)
Abstract Regulation of adipose tissue stem cells (ASCs) and adipogenesis impact the development of excess body fat-related metabolic complications. Animal studies have suggested the presence of distinct subtypes of ASCs with different differentiation
Externí odkaz:
https://doaj.org/article/6b3adb523481403fa689ec1e398a945a
Autor:
Paul Petrus, Niklas Mejhert, Patricia Corrales, Simon Lecoutre, Qian Li, Estela Maldonado, Agne Kulyté, Yamila Lopez, Mark Campbell, Juan R. Acosta, Jurga Laurencikiene, Iyadh Douagi, Hui Gao, Concepción Martínez-Álvarez, Per Hedén, Kirsty L. Spalding, Antonio Vidal-Puig, Gema Medina-Gomez, Peter Arner, Mikael Rydén
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 551-560.e5 (2018)
Summary: White adipose tissue (WAT) mass is determined by adipocyte size and number. While adipocytes are continuously turned over, the mechanisms controlling fat cell number in WAT upon weight changes are unclear. Herein, prospective studies of huma
Externí odkaz:
https://doaj.org/article/9419d552f02b4179bebb20837d864c38
Autor:
Ghazaleh Assadi, Liselotte Vesterlund, Ferdinando Bonfiglio, Luca Mazzurana, Lina Cordeddu, Danika Schepis, Jenny Mjösberg, Sabrina Ruhrmann, Alessia Fabbri, Vladana Vukojevic, Piergiorgio Percipalle, Florian A Salomons, Jurga Laurencikiene, Leif Törkvist, Jonas Halfvarson, Mauro D'Amato
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168276 (2016)
Genetic variation in the Laccase (multicopper oxidoreductase) domain-containing 1 (LACC1) gene has been shown to affect the risk of Crohn's disease, leprosy and, more recently, ulcerative colitis and juvenile idiopathic arthritis. LACC1 function appe
Externí odkaz:
https://doaj.org/article/1f338db8639a414e87b43c5673db812f
Autor:
Erik Arner, Alistair R R Forrest, Anna Ehrlund, Niklas Mejhert, Masayoshi Itoh, Hideya Kawaji, Timo Lassmann, Jurga Laurencikiene, Mikael Rydén, Peter Arner, FANTOM Consortium
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e80274 (2014)
Obesity confers an increased risk of developing specific cancer forms. Although the mechanisms are unclear, increased fat cell secretion of specific proteins (adipokines) may promote/facilitate development of malignant tumors in obesity via cross-tal
Externí odkaz:
https://doaj.org/article/e7a79dc9449a4d2987e2a0d7c85b2328