Výsledky vyhledávání - "Jurg van der Walt"

Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice

Autor: Timoteo Olamendi-Portugal, Jorge Paniagua, Blanca I. García-Gómez, Lourival D. Possani, Karin Dyason, Jurg van der Walt

Publikováno v: Toxicon. 53:770-778

A novel peptide named Pg8 was purified from the venom of the South African scorpion Parabuthus granulatus and its primary structure was determined. It contains 63 amino acid residues tightly folded by 4 disulfide bridges. The gene coding for this pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c329bf75e3f4144e34fc422ea35a2479
https://doi.org/10.1016/j.toxicon.2009.02.011

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A Subfamily of Acidic α-K+ Toxins

Autor: Blanca I. García-Gómez, Jurg van der Walt, Isabelle Huys, Timoteo Olamendi-Portugal, Karin Dyason, Isabel Vandenberghe, Jan Tytgat, Elke Clynen, Shunyi Zhu, Jozef Van Beeumen, Lourival D. Possani

Publikováno v: Journal of Biological Chemistry. 279:2781-2789

Three homologous acidic peptides have been isolated from the venom of three different Parabuthus scorpion species, P. transvaalicus, P. villosus, and P. granulatus. Analysis of the primary sequences reveals that they structurally belong to subfamily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38f77e1ba22a2b915545c0d8d031b1e5
https://doi.org/10.1074/jbc.m311029200

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Scorpion toxins that block T-type Ca2+ channels in spermatogenic cells inhibit the sperm acrosome reaction

Autor: José L. De la Vega-Beltrán, Timoteo Olamendi-Portugal, Karin Dyason, Jurg van der Walt, Alberto Darszon, Ricardo Felix, Lourival D. Possani, Ignacio López-González

Publikováno v: Biochemical and Biophysical Research Communications. 300:408-414

The acrosome reaction (AR) is a Ca(2+)-dependent event required for sperm to fertilize the egg. The activation of T-type voltage-gated Ca(2+) channels plays a key role in the induction of this process. This report describes the actions of two toxins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83fb536f7b956d08fe3c3896617198a
https://doi.org/10.1016/s0006-291x(02)02859-0

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Antibacterial and antifungal properties of α-helical, cationic peptides in the venom of scorpions from southern Africa

Autor: Leentje Moerman, Jean Willems, Liliane Schoofs, Wim Noppe, Suzanne Bosteels, Karin Thevissen, Jan Tytgat, Fons Verdonck, Johan Van Eldere, Jurg van der Walt, Elke Clynen

Publikováno v: European Journal of Biochemistry. 269:4799-4810

Two novel pore-forming peptides have been isolated from the venom of the South-African scorpion Opistophtalmus carinatus. These peptides, designated opistoporin 1 and 2, differ by only one amino acid and belong to a group of alpha-helical, cationic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8a2a7b82bd6e915bd9bd957cbc66339
https://doi.org/10.1046/j.1432-1033.2002.03177.x

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Purification, characterization and biosynthesis of parabutoxin 3, a component ofParabuthus transvaalicusvenom

Autor: Liliane Schoofs, Isabelle Huys, Karin Dyason, Etienne Waelkens, G.J. Muller, Johann M. van Zyl, Jan Tytgat, Elke Clynen, Fons Verdonck, Jurg van der Walt, Johan du Plessis

Publikováno v: European Journal of Biochemistry. 269:1854-1865

A novel peptidyl inhibitor of voltage-gated K+ channels, named parabutoxin 3 (PBTx3), has been purified to homogeneity from the venom of Parabuthus transvaalicus. This scorpion toxin contains 37 residues, has a mass of 4274 Da and displays 41% identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15c7cd57a72029ad55169a6276ef2b19
https://doi.org/10.1046/j.1432-1033.2002.02833.x

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Determination of species-specific components in the venom ofParabuthusscorpions from southern Africa using matrix-assisted laser desorption time-of-flight mass spectrometry

Autor: Johan du Plessis, Wolf F. Brandt, Jan Tytgat, Fons Verdonck, Jurg van der Walt, Lorenzo Prendini, Karin Dyason, G. J. Muller

Publikováno v: Rapid Communications in Mass Spectrometry. 16:768-773

The aim of the present study was to analyze mass spectra of scorpions belonging to the genus Parabuthus (Pocock 1890) by means of matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOFMS) and to construct a species-specific veno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01dcaf869628a2870250260f2afe6be1
https://doi.org/10.1002/rcm.637

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A subfamily of acidic alpha-K(+) toxins

Autor: Isabelle, Huys, Timoteo, Olamendi-Portugal, Blanca Ines, Garcia-Gómez, Isabel, Vandenberghe, Jozef, Van Beeumen, Karin, Dyason, Elke, Clynen, Shunyi, Zhu, Jurg, van der Walt, Lourival D, Possani, Jan, Tytgat

Publikováno v: The Journal of biological chemistry. 279(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::418e35b3d30d7a9f618cab40f7c64642
https://pubmed.ncbi.nlm.nih.gov/14561751

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Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes

Autor: Fons Verdonck, Leentje Moerman, Wim Noppe, Jean Willems, Jurg van der Walt

Publikováno v: Toxicon : official journal of the International Society on Toxinology. 40(12)

We have isolated two cationic peptides, sharing partial homology with each other, from the venom of South African scorpions. Both synthetic peptides-one containing 44 amino acids, the other containing 45 amino acids-were constructed. At submicromolar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee58d089b30f9719e8b69d0370cfcd85
https://pubmed.ncbi.nlm.nih.gov/12457879

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