Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jurg Tschopp"'
Autor:
Kaiwen W. Chen, Christina J. Groß, Flor Vásquez Sotomayor, Katryn J. Stacey, Jurg Tschopp, Matthew J. Sweet, Kate Schroder
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 570-582 (2014)
The macrophage NLRC4 inflammasome drives potent innate immune responses against Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (e.g., interleukin-1β [IL-1β]) and pyroptotic cell death. However, the potential contrib
Externí odkaz:
https://doaj.org/article/f74eadcc92da400482d6b2afcb497393
Autor:
Edel A McNeela, Aine Burke, Daniel R Neill, Cathy Baxter, Vitor E Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M McLoughlin, Andres Mori, Barry Moran, Katherine A Fitzgerald, Jurg Tschopp, Virginie Pétrilli, Peter W Andrew, Aras Kadioglu, Ed C Lavelle
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001191 (2010)
Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells (DC) play a key role in the initiation and instruction of adaptive immunity, but the effects
Externí odkaz:
https://doaj.org/article/e10145540ddd48788b803169ff38aeef
Autor:
Catherine Dostert, Greta Guarda, Jackeline F Romero, Philippe Menu, Olaf Gross, Aubry Tardivel, Mario-Luca Suva, Jean-Christophe Stehle, Manfred Kopf, Ivan Stamenkovic, Giampietro Corradin, Jurg Tschopp
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6510 (2009)
BACKGROUND: Characteristic symptoms of malaria include recurrent fever attacks and neurodegeneration, signs that are also found in patients with a hyperactive Nalp3 inflammasome. Plasmodium species produce a crystal called hemozoin that is generated
Externí odkaz:
https://doaj.org/article/5a1b2ef8c64c49439e4111cbba995712
Supplementary Figure Legends 1-3 from Cells with Defective p53-p21-pRb Pathway Are Susceptible to Apoptosis Induced by p84N5 via Caspase-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad25d3a47f8d5ad51f50fd56bb0df5c3
https://doi.org/10.1158/0008-5472.22367829
https://doi.org/10.1158/0008-5472.22367829
Adeno-associated virus (AAV) infection triggers a DNA damage response in the cell. This response is not induced by viral proteins but by virtue of the structure of AAV ssDNA being recognized by the cell as damaged DNA. The consequence of this is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c4dae3024a3095432d5b097c51ca31
https://doi.org/10.1158/0008-5472.c.6495705
https://doi.org/10.1158/0008-5472.c.6495705
Supplementary Figure 1 from Cells with Defective p53-p21-pRb Pathway Are Susceptible to Apoptosis Induced by p84N5 via Caspase-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25adb04b9858fd7800b8df1ce4ae0e62
https://doi.org/10.1158/0008-5472.22367838
https://doi.org/10.1158/0008-5472.22367838
Supplementary Figure 2 from Cells with Defective p53-p21-pRb Pathway Are Susceptible to Apoptosis Induced by p84N5 via Caspase-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d8f7f6e852d397ccb15bca220dd8d3
https://doi.org/10.1158/0008-5472.22367835
https://doi.org/10.1158/0008-5472.22367835
Autor:
John Ding-E Young, Bella Felzen, Ofer Binah, Dalia Rosen, Gideon Berke, Reymond Coleman, Jurg Tschopp
Publikováno v:
Cardiovascular Research, vol. 28, no. 5, pp. 643-9
Objective: Involvement of cytotoxic T lymphocytes (CTL) in heart transplant rejection as well as in viral myocarditis is well established, but the precise mechanisms whereby infiltrating CTL damage the myocardium are unknown. The aim of the study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0d365148cdf2cfde8bd009408d4838
http://doc.rero.ch/record/297994/files/28-5-643.pdf
http://doc.rero.ch/record/297994/files/28-5-643.pdf
Autor:
Kate Schroder, Jurg Tschopp
Publikováno v:
CELL
SummaryInflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1β to engage innate immune defenses. Strong associations between dysregulated infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839682e957a52e28d8eb82fb3380ccdf
https://doi.org/10.1016/j.cell.2010.01.040
https://doi.org/10.1016/j.cell.2010.01.040
Autor:
Thomas Matthes, Juerg Schwaller, Thomas Alexander Mckee, Bertrand Huard, Pascal Schneider, Olivier Donzé, Jurg Tschopp, Samir Myit, Frédérique-Anne Le Gal, Paulette Mhawech-Fauceglia
Publikováno v:
Blood, vol. 109, no. 1, pp. 331-338
A PRoliferation-Inducing TNF Ligand (APRIL) costimulates B-cell activation. When overexpressed in mice, APRIL induces B-cell neoplasia, reminiscent of human B-cell chronic lymphoid leukemia (B-CLL). We analyzed APRIL expression in situ in human non-H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8654527653c2c8eb456441aa957787ff
https://doi.org/10.1182/blood-2006-02-001800
https://doi.org/10.1182/blood-2006-02-001800