Zobrazeno 1 - 10
of 457
pro vyhledávání: '"Jurg Ott"'
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
To locate disease-causing DNA variants on the human gene map, the customary approach has been to carry out a genome-wide association study for one variant after another by testing for genotype frequency differences between individuals affected and un
Externí odkaz:
https://doaj.org/article/33eac9754856493d81ab2a25ea01de3d
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/1d1312c441954f4282e4f5b5e1ad216f
Autor:
Mutaz Amin, Jurg Ott, Derek Gordon, Rongling Wu, Teodor T. Postolache, Michael Vergare, Claudia Gragnoli
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9819 (2022)
The corticotropin-releasing hormone receptor 2 (CRHR2) gene encodes CRHR2, contributing to the hypothalamic–pituitary–adrenal stress response and to hyperglycemia and insulin resistance. CRHR2−/− mice are hypersensitive to stress, and the CRH
Externí odkaz:
https://doaj.org/article/aac764b61bfe467592a7038e1b6268ac
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8350 (2022)
The melanocortin receptors are G-protein-coupled receptors, which are essential components of the hypothalamic–pituitary–adrenal axis, and they mediate the actions of melanocortins (melanocyte-stimulating hormones: α-MSH, β-MSH, and γ-MSH) as
Externí odkaz:
https://doaj.org/article/ef14544690bb4de5b588d7492b648a95
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
BackgroundDue to the affordability of whole-genome sequencing, the genetic association design can now address rare diseases. However, some common statistical association methods only consider homozygosity mapping and need several criteria, such as sl
Externí odkaz:
https://doaj.org/article/45e89df4a2c7400a93fedccc76383737
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224399 (2019)
There is a reciprocal relationship between the circadian and the reward systems. Polymorphisms in several circadian rhythm-related (clock) genes were associated with drug addiction. This study aims to search for associations between 895 variants in 3
Externí odkaz:
https://doaj.org/article/42d7f83dbaad4d879601d0bbf7a3167e
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 6, p e1003627 (2014)
Identifying gene-gene interaction is a hot topic in genome wide association studies. Two fundamental challenges are: (1) how to smartly identify combinations of variants that may be associated with the trait from astronomical number of all possible c
Externí odkaz:
https://doaj.org/article/6af5d0b129634e8a9d6722a40c4c2325
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46335 (2012)
BACKGROUND: Major depressive disorder (MDD) is a complex neuropsychiatric syndrome with high heterogeneity. There are different levels of biological components that underlie MDD and interact with each other. To uncover the disease mechanism, large nu
Externí odkaz:
https://doaj.org/article/2d9822be388e4601b7316249323b9b08
Autor:
Kyung-Tai Lee, Mi-Jeong Byun, Kyung-Soo Kang, Eung-Woo Park, Seung-Hwan Lee, Seoae Cho, Hyoyoung Kim, Kyu-Won Kim, Taeheon Lee, Jong-Eun Park, Woncheoul Park, Donghyun Shin, Hong-Seog Park, Jin-Tae Jeon, Bong-Hwan Choi, Gul-Won Jang, Sang-Haeng Choi, Dae-Won Kim, Dajeong Lim, Hae-Suk Park, Mi-Rim Park, Jurg Ott, Lawrence B Schook, Tae-Hun Kim, Heebal Kim
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16356 (2011)
Obesity represents a major global public health problem that increases the risk for cardiovascular or metabolic disease. The pigs represent an exceptional biomedical model related to energy metabolism and obesity in humans. To pinpoint causal genetic
Externí odkaz:
https://doaj.org/article/7f9b4f4aacbf4add8ca75375f302d0e0
Publikováno v:
Arquivos de Neuro-Psiquiatria, Vol 49, Iss 3, Pp 285-291 (1991)
A family suffering an autosomal dominant form of late onset hereditary cerebellar ataxia is described. Eight affected family members were personally studied, and data from another four were obtained through anamnesis. The mean age of onset was 37.1±
Externí odkaz:
https://doaj.org/article/045d998c0d0e45b1ab5e14fd9c2e497b