Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Juraj Kramara"'
Autor:
Juraj Kramara, Min-Ju Kim, Tomye L. Ollinger, Laura C. Ristow, Rohan S. Wakade, Robert Zarnowski, Melanie Wellington, David R. Andes, Aaron G. Mitchell, Damian J. Krysan
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Protein kinases are critical regulatory proteins in both prokaryotes and eukaryotes. Accordingly, protein kinases represent a common drug target for a wide range of human diseases. Therefore, understanding protein kinase function in human pa
Externí odkaz:
https://doaj.org/article/238395d27ac94527a0cb81bc2924258a
Autor:
Virginia E. Glazier, Juraj Kramara, Tomye Ollinger, Norma V. Solis, Robert Zarnowski, Rohan S. Wakade, Min-Ju Kim, Gabriel J. Weigel, Shen-Huan Liang, Richard J. Bennett, Melanie Wellington, David R. Andes, Mark A. Stamnes, Scott G. Filler, Damian J. Krysan
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Candida albicans is a diploid human fungal pathogen that displays significant genomic and phenotypic heterogeneity over a range of virulence traits and in the context of a variety of environmental niches. Here, we show that the effect of Rob
Externí odkaz:
https://doaj.org/article/d9d88ba2cedc4442aa5ec5ea0648059b
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Candida albicans is one of the most prevalent human fungal pathogens. Its ability to transition between budding yeast and filamentous morphological forms (pseudohyphae and hyphae) is tightly associated with its pathogenesis. Based on in vitr
Externí odkaz:
https://doaj.org/article/f5c85fa415fb4fbd9e7cd7155c73acfe
Publikováno v:
Nucleic Acids Research
Microhomology-mediated break-induced replication (MMBIR) is a DNA repair pathway initiated by polymerase template switching at microhomology, which can produce templated insertions that initiate chromosomal rearrangements leading to neurological and
Autor:
Hana Paculová, Juraj Kramara, Šárka Šimečková, Radek Fedr, Karel Souček, Ondřej Hylse, Kamil Paruch, Marek Svoboda, Martin Mistrík, Jiří Kohoutek
Publikováno v:
Tumor Biology, Vol 39 (2017)
A broad spectrum of tumors develop resistance to classic chemotherapy, necessitating the discovery of new therapies. One successful strategy exploits the synthetic lethality between poly(ADP-ribose) polymerase 1/2 proteins and DNA damage response gen
Externí odkaz:
https://doaj.org/article/e7bcbdc4ad754e1e8d403ed31b65297e
Publikováno v:
Methods Mol Biol
Homologous Recombination ISBN: 9781071606438
Homologous Recombination ISBN: 9781071606438
Repair of double-strand DNA breaks (DSBs) is important for preserving genomic integrity and stability. Break-induced replication (BIR) is a mechanism aimed to repair one-ended double-strand DNA breaks, similar to those formed by replication fork coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c273b1fd8e4a9e0828f5ad39e7cdb6
https://europepmc.org/articles/PMC9041317/
https://europepmc.org/articles/PMC9041317/
Microhomology-mediated break-induced replication (MMBIR) is a mechanism of polymerase template switching at microhomology, which can produce complex genomic rearrangements (CGRs), underlies neurological and metabolic diseases, and contributes to canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b50085f6ce3940cadfb6194738741c
https://doi.org/10.1101/2020.07.19.209445
https://doi.org/10.1101/2020.07.19.209445
Publikováno v:
Trends in Genetics. 34:518-531
Break-induced replication (BIR) is a pathway that repairs one-ended double-strand breaks (DSBs). For decades, yeast model systems offered the only opportunities to study eukaryotic BIR. These studies described an unusual mode of BIR synthesis that is
Autor:
Martin Mistrik, Radek Fedr, Ondřej Hylse, Jiří Kohoutek, Šárka Šimečková, Kamil Paruch, Juraj Kramara, Hana Paculová, Karel Souček, Marek Svoboda
Publikováno v:
Tumor Biology, Vol 39 (2017)
A broad spectrum of tumors develop resistance to classic chemotherapy, necessitating the discovery of new therapies. One successful strategy exploits the synthetic lethality between poly(ADP-ribose) polymerase 1/2 proteins and DNA damage response gen
Publikováno v:
Nature structuralmolecular biology. 24(1)
Determining the molecular mechanisms responsible for trinucleotide DNA repeat expansions is critical, as such expansions underlie many neuromuscular and neurodegenerative disorders. Mirkin and colleagues now propose that large-scale expansions of tri