Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Juraj Kabat"'
Autor:
Andrea J. Luker, Abigail Wukitch, Joseph M. Kulinski, Sundar Ganesan, Juraj Kabat, Justin Lack, Pamela Frischmeyer-Guerrerio, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The successful development of germinal centers (GC) relies heavily on innate mechanisms to amplify the initial inflammatory cascade. In addition to their role in antigen presentation, innate cells are essential for the redirection of circulating lymp
Externí odkaz:
https://doaj.org/article/d8c9be8b0eb9405087e8bc07eb6babcf
Autor:
Sang Hun Lee, Byunghyun Kang, Olena Kamenyeva, Tiago Rodrigues Ferreira, Kyoungin Cho, Jaspal S. Khillan, Juraj Kabat, Brian L. Kelsall, David L. Sacks
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Tissue-resident macrophages are critical for tissue homeostasis and repair. We previously showed that dermis-resident macrophages produce CCL24 which mediates their interaction with IL-4+ eosinophils, required to maintain their M2-like prope
Externí odkaz:
https://doaj.org/article/9b9bb96b2d714cf39e936ddda5e4e07b
Autor:
Munir Akkaya, Jafar Al Souz, Daniel Williams, Rahul Kamdar, Olena Kamenyeva, Juraj Kabat, Ethan Shevach, Billur Akkaya
Publikováno v:
eLife, Vol 12 (2024)
Delineating the complex network of interactions between antigen-specific T cells and antigen presenting cells (APCs) is crucial for effective precision therapies against cancer, chronic infections, and autoimmunity. However, the existing arsenal for
Externí odkaz:
https://doaj.org/article/fa37a84c2daa401bbccbb746c12a3d89
Autor:
Mritunjay Pandey, Jian-Hua Zhang, Poorni R. Adikaram, Claire Kittock, Nicole Lue, Adam Awe, Katherine Degner, Nirmal Jacob, Jenna Staples, Rachel Thomas, Allison B. Kohnen, Sundar Ganesan, Juraj Kabat, Ching-Kang Chen, William F. Simonds
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Mechanical, thermal, and chemical pain sensation is conveyed by primary nociceptors, a subset of sensory afferent neurons. The intracellular regulation of the primary nociceptive signal is an area of active study. We report here the discovery of a G
Externí odkaz:
https://doaj.org/article/04100bd6616e4b5b8c76a81a09c61a61
Autor:
Sarah Sattar, Juraj Kabat, Kailey Jerome, Friederike Feldmann, Kristina Bailey, Masfique Mehedi
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes severe pathophysiology in vulnerable older populations and appears to be highly pathogenic and more transmissible than other coronaviruses. The spike (S) protein appears to be a majo
Externí odkaz:
https://doaj.org/article/ff7e6eee8b134b198a958f2bc59899f7
Autor:
Rama K. Gurram, Danping Wei, Qiao Yu, Olena Kamenyeva, Hyunwoo Chung, Mingzhu Zheng, Matthew J. Butcher, Juraj Kabat, Chengyu Liu, Jaspal S. Khillan, Jinfang Zhu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T helper-2 (Th2) cells and type 2 innate lymphoid cells (ILC2s) play crucial roles during type 2 immune responses; the transcription factor GATA3 is essential for the differentiation and functions of these cell types. It has been demonstrated that GA
Externí odkaz:
https://doaj.org/article/7086e6abc9e0457685c63d6ddf0cd319
Autor:
Cecilia B. Korol, Shamira J. Shallom, Kriti Arora, Helena I. Boshoff, Alexandra F. Freeman, Alejandra King, Sonia Agrawal, Sean C. Daugherty, Timothy Jancel, Juraj Kabat, Sundar Ganesan, Marina N. Torrero, Elizabeth P. Sampaio, Clifton Barry, Steve M Holland, Hervé Tettelin, Sergio D Rosenzweig, Adrian M. Zelazny
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 1656-1673 (2020)
Summary: We characterized Mycobacterium bovis BCG isolates found in lung and brain samples from a previously vaccinated patient with IFNγR1 deficiency. The isolates collected displayed distinct genomic and phenotypic features consistent with host ad
Externí odkaz:
https://doaj.org/article/c389e6b7ad754220ad0f5defb0a60810
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT The life cycle of human papillomavirus (HPV) depends on keratinocyte differentiation as the virus modulates and takes advantage of cellular pathways to replicate its genome and assemble viral particles in differentiated cells. Viral genomes
Externí odkaz:
https://doaj.org/article/f31a631ba8ce4648b8bacf7d8c4ae011
Autor:
Serena Li-Sue Yan, Il-Young Hwang, Olena Kamenyeva, Juraj Kabat, Ji Sung Kim, Chung Park, John H. Kehrl
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophil trafficking, homeostatic and pathogen elicited, depends upon chemoattractant receptors triggering heterotrimeric G-protein Gαiβγ signaling, whose magnitude and kinetics are governed by RGS protein/Gαi interactions. RGS proteins typical
Externí odkaz:
https://doaj.org/article/0b81604be47746a48941ea2854ac34c7
Autor:
Vandana Sekhar, Teresa Pollicino, Giacomo Diaz, Ronald E Engle, Farah Alayli, Marta Melis, Juraj Kabat, Ashley Tice, Anna Pomerenke, Nihal Altan-Bonnet, Fausto Zamboni, Paolo Lusso, Suzanne U Emerson, Patrizia Farci
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006916 (2018)
Entry of hepatitis C virus (HCV) into hepatocytes is a complex process that involves numerous cellular factors, including the scavenger receptor class B type 1 (SR-B1), the tetraspanin CD81, and the tight junction (TJ) proteins claudin-1 (CLDN1) and
Externí odkaz:
https://doaj.org/article/787e8f5e0db9407196241f0eb0ac56ca