Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Juraj Simunić"'
Publikováno v:
eLife, Vol 11 (2022)
The human mitotic spindle is made of microtubules nucleated at centrosomes, at kinetochores, and from pre-existing microtubules by the augmin complex. However, it is unknown how the augmin-mediated nucleation affects distinct microtubule classes and
Externí odkaz:
https://doaj.org/article/2245be649c4d4a319d992f34261ae797
Autor:
Maja Novak, Bruno Polak, Juraj Simunić, Zvonimir Boban, Barbara Kuzmić, Andreas W. Thomae, Iva M. Tolić, Nenad Pavin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Forces are required for congression of chromosomes by microtubule spindles. Here, using super-resolution microscopy and computational modelling, the authors find that in addition to forces, torques caused by the microtubule motor protein kinesin-5 in
Externí odkaz:
https://doaj.org/article/6c7f670a0f214d33b19b8f2d1e62ae20
Publikováno v:
eLife
The mitotic spindle functions as a molecular micromachine that evenly distributes chromosomes into two daughter cells during cell division. A major mechanical element of the spindle are kinetochore fibers attached to sister kinetochores on each chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105336bf8a2cbe71979a7484df219429
https://pubmed.ncbi.nlm.nih.gov/36269126
https://pubmed.ncbi.nlm.nih.gov/36269126
Publikováno v:
Entropy, Vol 21, Iss 8, p 743 (2019)
Transitions between enzyme functional states are often connected to conformational changes involving electron or proton transport and directional movements of a group of atoms. These microscopic fluxes, resulting in entropy production, are driven by
Externí odkaz:
https://doaj.org/article/6ee04dda5f39419dafc2297b64b8f9ea
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78760 (2013)
The evolutionary conserved Mre11/Rad50/Nbs1 complex functions as one of the guardians of genome integrity in eukaryotes; it is required for the double-strand break repair, meiosis, DNA checkpoint, and telomere maintenance. To better understand the ro
Externí odkaz:
https://doaj.org/article/95d214c11d914c45b01f249ff405378e
Autor:
Bruno Polak, Maja Novak, Juraj Simunić, Iva M. Tolić, Nenad Pavin, Andreas W. Thomae, Zvonimir Boban, Barbara Kuzmić
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Volume 9
Nature Communications
Volume 9
Mitosis relies on forces generated in the spindle, a micro-machine composed of microtubules and associated proteins. Forces are required for the congression of chromosomes to the metaphase plate and their separation in anaphase. However, besides forc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396c0e65cbcaf8e8c5dd982ae336a56c
http://link.springer.com/article/10.1038/s41467-018-06005-7
http://link.springer.com/article/10.1038/s41467-018-06005-7
Autor:
Juraj Simunić, Radhika Subramanian
Publikováno v:
Journal of Cell Science. 132
Leading scientists from the field of mitotic spindle research gathered from 24–27 March 2019 to participate in the first ‘Mitotic spindle: From living and synthetic systems to theory’ conference. This meeting was held in Split, Croatia, organiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf26beac73fbc647cfcbc0feafae3bc
https://doi.org/10.1242/jcs.237602
https://doi.org/10.1242/jcs.237602
Autor:
Juraj Simunić, Iva M. Tolić
Publikováno v:
Developmental Cell
The spindle relies on forces exerted by microtubules and motor proteins to align and segregate chromosomes. In this issue of Developmental Cell, Takagi et al. (2019) show that meiotic spindle microtubules respond differently to forces at different sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e04e6ce8f08b9d55fe633f9c611308
https://pubmed.ncbi.nlm.nih.gov/30982663
https://pubmed.ncbi.nlm.nih.gov/30982663
Publikováno v:
Plant Biology. 18:681-694
Given the fundamental role of the MRE11 in many aspects of DNA metabolism and signaling in eukaryotes, we analyzed the impact of several MRE11 mutations on DNA damage response (DDR) and DNA repair in Arabidopsis thaliana. Three different atmre11 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f7bfd1a24c54260c4a3bdd9e2f432b
https://doi.org/10.1111/plb.12453
https://doi.org/10.1111/plb.12453