Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Juqun Shen"'
Autor:
Yongjun Yin, Xiaodi Ren, Craig Smith, Qianxu Guo, Maria Malabunga, Ilhem Guernah, Yiwei Zhang, Juqun Shen, Haijun Sun, Nabil Chehab, Nick Loizos, Dale L. Ludwig, David M. Ornitz
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 5, Pp 563-571 (2016)
Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects. In human lung cancer, fibroblast growth factor 9 (FGF9), a high-affinity ligand for FGFR3, is
Externí odkaz:
https://doaj.org/article/5ac0feb2ecbf488585a464818511769e
Autor:
Juqun Shen, Marie Danielle Vil, Marie Prewett, Chris Damoci, Haifan Zhang, Huiling Li, Xenia Jimenez, Dhanvanthri S. Deevi, Michelle Iacolina, Anthony Kayas, Rajiv Bassi, Kris Persaud, Anna Rohoza-Asandi, Paul Balderes, Nick Loizos, Dale L. Ludwig, James Tonra, Larry Witte, Zhenping Zhu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 6, Pp 594-604 (2009)
Platelet-derived growth factor receptor β (PDGFRβ) is upregulated in most of solid tumors. It is expressed by pericytes/smooth muscle cells, fibroblast, macrophage, and certain tumor cells. Several PDGF receptor-related antagonists are being develo
Externí odkaz:
https://doaj.org/article/2da6a13c5fe745ada07cc15c83ebd27c
Autor:
Michael Kalos, Gregory D. Plowman, Dale L. Ludwig, Ruslan D. Novosiadly, Douglas Burtrum, Yiwei Zhang, Prachi Sharma, Lauren Boucher, Michael Topper, Andreas Sonyi, Darin Chin, Xinlei Chen, Amelie Forest, Anthony L. Pennello, Ivan Inigo, Leyi Shen, Colleen Burns, Jaafar N. Haidar, David Surguladze, Jingxing Li, Juqun Shen, Carmine Carpenito, Maria B. Lebron, Rose Marie Sattler, Helen Kotanides
Figure S3 shows CD137 receptor modulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3bb6a3afe5cfbbb01f18d1ddaccd41
https://doi.org/10.1158/1535-7163.22519410
https://doi.org/10.1158/1535-7163.22519410
Autor:
Michael Kalos, Gregory D. Plowman, Dale L. Ludwig, Ruslan D. Novosiadly, Douglas Burtrum, Yiwei Zhang, Prachi Sharma, Lauren Boucher, Michael Topper, Andreas Sonyi, Darin Chin, Xinlei Chen, Amelie Forest, Anthony L. Pennello, Ivan Inigo, Leyi Shen, Colleen Burns, Jaafar N. Haidar, David Surguladze, Jingxing Li, Juqun Shen, Carmine Carpenito, Maria B. Lebron, Rose Marie Sattler, Helen Kotanides
Table S2 shows human immune effector ADCC and CDC activity EC50 (nM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a7d8844ae274ecd96486d49338c0e0
https://doi.org/10.1158/1535-7163.22519383
https://doi.org/10.1158/1535-7163.22519383
Autor:
Michael Kalos, Gregory D. Plowman, Dale L. Ludwig, Ruslan D. Novosiadly, Douglas Burtrum, Yiwei Zhang, Prachi Sharma, Lauren Boucher, Michael Topper, Andreas Sonyi, Darin Chin, Xinlei Chen, Amelie Forest, Anthony L. Pennello, Ivan Inigo, Leyi Shen, Colleen Burns, Jaafar N. Haidar, David Surguladze, Jingxing Li, Juqun Shen, Carmine Carpenito, Maria B. Lebron, Rose Marie Sattler, Helen Kotanides
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20e7787d1efd66b5f6dc06f92584d9f
https://doi.org/10.1158/1535-7163.22519389
https://doi.org/10.1158/1535-7163.22519389
Autor:
Douglas Burtrum, Helen Kotanides, Leyi Shen, Darin Chin, Ruslan D. Novosiadly, Amelie Forest, Rose Marie Sattler, Xinlei Chen, Yiwei Zhang, Michael Topper, David Surguladze, Jingxing Li, Jaafar N. Haidar, Ivan Inigo, Gregory D. Plowman, Colleen A. Burns, Lauren Boucher, Andreas Sonyi, Prachi Sharma, Michael Kalos, Dale L. Ludwig, Maria B. Lebron, Anthony Pennello, Carmine Carpenito, Juqun Shen
Publikováno v:
Molecular Cancer Therapeutics. 19:988-998
The CD137 receptor plays a key role in mediating immune response by promoting T cell proliferation, survival, and memory. Effective agonism of CD137 has the potential to reinvigorate potent antitumor immunity either alone or in combination with other
Autor:
David Surguladze, Kris Persaud, Douglas Burtrum, Sudhakar Chintharlapalli, Aiping Zhu, Marie Prewett, Sagit Hindi, Paul Balderes, Ruslan Novosyadlyy, Yun (Kenneth) Kang, Haifan Zhang, Scott W. Eastman, Juqun Shen, Yang Shen, Lin Zeng, Zhenping Zhu, Nicole Covino, Michael Topper, Marshall Snavely, Dale L. Ludwig, Andrew Ihor Korytko, Amelie Forest, Victor J. Wroblewski
Publikováno v:
mAbs
Bi-specific antibodies (BsAbs), which can simultaneously block 2 tumor targets, have emerged as promising therapeutic alternatives to combinations of individual monoclonal antibodies. Here, we describe the engineering and development of a novel, huma
Autor:
Xiaodi Ren, Maria Malabunga, Ilhem Guernah, Qianxu Guo, Yongjun Yin, Craig Smith, Haijun Sun, David M. Ornitz, Nick Loizos, Nabil Chehab, Juqun Shen, Dale L. Ludwig, Yiwei Zhang
Publikováno v:
Disease Models & Mechanisms.
Activating mutations in Fibroblast Growth Factor Receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects. In human lung cancer, Fibroblast Growth Factor 9 (FGF9), a high affinity ligand for FGFR3, is
Autor:
Wen-Chih Chiang, Huan Lun Hsu, Shuei-Liong Lin, Kwan-Dun Wu, Yi-Ting Chen, Jeremy S. Duffield, Yung-Ming Chen, Tun-Jun Tsai, Fan-Chi Chang, Juqun Shen, Yu-Hsiang Chou, Ching Fang Wu
Publikováno v:
Kidney International. 80:1170-1181
Pericytes are the major source of scar-producing myofibroblasts following kidney injury; however, the mechanisms of this transition are unclear. To clarify this, we examined Collagen 1 (α1)-green fluorescent protein (GFP) reporter mice (pericytes an
Autor:
Anthony Kayas, Marie Prewett, Paul Balderes, Dhanvanthri S. Deevi, Michelle Iacolina, Huiling Li, Larry Witte, Zhenping Zhu, Chris Damoci, Anna Rohoza-Asandi, Marie Danielle Vil, Haifan Zhang, Juqun Shen, Kris Persaud, James R. Tonra, Rajiv Bassi, Dale L. Ludwig, Xenia Jimenez, Nick Loizos
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 6, Pp 594-604 (2009)
Platelet-derived growth factor receptor beta (PDGFRbeta) is upregulated in most of solid tumors. It is expressed by pericytes/smooth muscle cells, fibroblast, macrophage, and certain tumor cells. Several PDGF receptor-related antagonists are being de