Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Juong G. Rhee"'
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50423 (2012)
There are contradictory observations about the different radiosensitivities of cancer stem cells and cancer non-stem cells. To resolve these contradictory observations, we studied radiosensitivities by employing breast cancer stem cell (CSC)-like MDA
Externí odkaz:
https://doaj.org/article/26fde4ac32e74fe8a4c33a21edf0634b
Autor:
Tzu-Cheg Kao, Juong G. Rhee, Mark H. Whitnall, Marcy B. Grace, William E. Jackson, Vijay K. Singh
Publikováno v:
Journal of Radiation Research
The steroid androst-5-ene-3ß,17ß-diol (5-androstenediol, 5-AED) elevates circulating granulocytes and platelets in animals and humans, and enhances survival during the acute radiation syndrome (ARS) in mice and non-human primates. 5-AED promotes su
Publikováno v:
British Journal of Pharmacology. 157:1189-1202
Background and purpose: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptotic death in a variety of cancer cells without marked toxicity to most normal cells. We previously reported that wogonin, a potent anticancer agen
Publikováno v:
International Journal of Radiation Biology. 84:515-522
The prolonged delivery times associated with intensity modulated radiation therapy (IMRT) may reduce treatment effectiveness of radiation therapy for cancers with short repair half-times. In this study, in vitro radiation experiments with DU-145 pros
Autor:
Daqing Li, Juong G. Rhee, Mohan Suntharalingam, Chuanfa Guo, James P. Carney, Bert W. O'Malley
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 67:273-278
Purpose: Local failure and toxicity to adjacent critical structures is a significant problem in radiation therapy of cancers of the head and neck. We are developing a gene therapy based method of sensitizing head/neck squamous cell carcinoma (HNSCC)
Autor:
Joon Young Ahn, H. Moo Kwon, Seung Kyoon Woo, Juong G. Rhee, Ju-Young Jung, Mee Rie Sheen, Seung Whan Kim
Publikováno v:
American Journal of Physiology-Renal Physiology. 291:F1014-F1020
When exposed to hypertonic conditions, cells accumulate double-strand DNA breaks (DSBs) like they are exposed to ionizing radiation. It has been proposed that inactivation of the Mre11-Rad50-Nbs1 (MRN) complex due to nuclear exit is responsible for t
Publikováno v:
Molecular and Cellular Biochemistry. 270:89-97
Tumor microenvironment, which is characterized by hypoxia, low-glucose concentrations, high-lactate concentrations, low-extracellular pH, can alter the therapeutic response in tumors. In this study, we investigated whether hypoxia affects TRAIL-induc
Autor:
Keith T. Wilson, Francoise I. Bussiere, Mohammad Asim, Steven F. Moss, Hangxiu Xu, Juong G. Rhee, Sung Soo Kim, Yulan Cheng, Micheal D. Yao, Stephen J. Meltzer, Amy Hacker, Rupesh Chaturvedi, Yanlin Wang, Robert A. Casero, Darryn Potosky
Publikováno v:
Cancer Research
Cancer Research, American Association for Cancer Research, 2004, 64 (23), pp.8521-8525. ⟨10.1158/0008-5472.CAN-04-3511⟩
Cancer Research, American Association for Cancer Research, 2004, 64 (23), pp.8521-8525. ⟨10.1158/0008-5472.CAN-04-3511⟩
Oxidative stress is linked to carcinogenesis due to its ability to damage DNA. The human gastric pathogen Helicobacter pylori exerts much of its pathogenicity by inducing apoptosis and DNA damage in host gastric epithelial cells. Polyamines are abund
Publikováno v:
ORL. 65:144-154
Since adenoviral p16INK4A gene transfer has shown limited promise in preclinical studies, we developed a strategy combining ionizing radiation (x-rays) with Ad-p16 gene therapy. Both radiation (2 Gy) and Ad-p16 alone demonstrated anti-tumor responses
Autor:
Juong G. Rhee, Susan A. Walsh, Jae J. Song, Yong J. Lee, Douglas R. Spitz, Mohan Suntharalingam
Publikováno v:
Journal of Biological Chemistry. 277:46566-46575
Epitope-tagged glutaredoxin (GRX) was utilized to determine the role of GRX in oxidative stress-induced signaling and cytotoxicity in glucose-deprived human cancer cells (MCF-7/ADR and DU-145). GRX-overexpressing cells demonstrated resistance to gluc