Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Juo-Chin Yao"'
Autor:
Juo-Chin Yao, Karolyn A. Oetjen, Tianjiao Wang, Haoliang Xu, Grazia Abou-Ezzi, Joseph R. Krambs, Salil Uttarwar, Eric J. Duncavage, Daniel C. Link
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Myeloproliferative neoplasms (MPNs) are associated with significant alterations in the bone marrow microenvironment that include decreased expression of key niche factors and myelofibrosis. Here, we explored the contribution of TGF-β to these altera
Externí odkaz:
https://doaj.org/article/16c7679cd4574cb4aab528f73e5a6fc5
Autor:
Bac Viet Le, Paulina Podszywalow-Bartnicka, Silvia Maifrede, Katherine Sullivan-Reed, Margaret Nieborowska-Skorska, Konstantin Golovine, Juo-Chin Yao, Reza Nejati, Kathy Q. Cai, Lisa Beatrice Caruso, Julian Swatler, Michal Dabrowski, Zhaorui Lian, Peter Valent, Elisabeth M. Paietta, Ross L. Levine, Hugo F. Fernandez, Martin S. Tallman, Mark R. Litzow, Jian Huang, Grant A. Challen, Daniel Link, Italo Tempera, Mariusz A. Wasik, Katarzyna Piwocka, Tomasz Skorski
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108221- (2020)
Summary: Synthetic lethality triggered by PARP inhibitor (PARPi) yields promising therapeutic results. Unfortunately, tumor cells acquire PARPi resistance, which is usually associated with the restoration of homologous recombination, loss of PARP1 ex
Externí odkaz:
https://doaj.org/article/60f114cafa24497a8542aae9dc95851f
Autor:
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Tong Yang, Dustin Kress, Kai Sun, Kourtney L Kostecki, Joseph B Monahan, Deborah J Veis, Yousef Abu-Amer, Daniel C Link, Gabriel Mbalaviele
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000807 (2020)
Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation (BMT). Cytotoxicity limits the use of this life-saving therapy, but the underlying mechanisms remain poorly defined. Here, we use the syngeneic mouse BMT model to te
Externí odkaz:
https://doaj.org/article/dfcc01b5a9e84be9b30dca2343479fa0
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233751 (2020)
Mesenchymal stromal cells are an important component of the bone marrow hematopoietic niche. Prior studies showed that signaling from members of the transforming growth factor (TGF) superfamily in mesenchymal stromal cells is required for normal nich
Externí odkaz:
https://doaj.org/article/2462d614da9846c1b050a115b13aa141
Autor:
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Canxin Xu, Dustin Kress, Roberto Civitelli, Yousef Abu-Amer, Thirumala-Devi Kanneganti, Daniel C Link, Gabriel Mbalaviele
Publikováno v:
PLoS Biology, Vol 16, Iss 11, p e3000047 (2018)
Mutated NLRP3 assembles a hyperactive inflammasome, which causes excessive secretion of interleukin (IL)-1β and IL-18 and, ultimately, a spectrum of autoinflammatory disorders known as cryopyrinopathies of which neonatal-onset multisystem inflammato
Externí odkaz:
https://doaj.org/article/266b07cae49e41b7aebe6122e5a1256f
Autor:
Daniel C. Link, Pavan R. Reddy, Ivan Maillard, Timothy J. Ley, Todd A. Fehniger, Melissa M. Berrien-Elliott, Nishi Parikh, Gloria Jih, Yaping Sun, Jack Baty, Iris Kuo, Rahul Ramaswamy, Juo-Chin Yao, Terrence N. Wong, Maria C. Trissal
Supplementary Materials and Methods// Supplementary Figure 1. Supporting Figure 1. MIR142 mutations attenuate miR-142-3p and miR-142-5p functions.// Supplementary Figure 2. Supporting Figure 2. Mir142 loss alters differentiation in mature hematopoiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0784f8483dcccce1ec02ecca51daef31
https://doi.org/10.1158/0008-5472.22419527.v1
https://doi.org/10.1158/0008-5472.22419527.v1
Autor:
Daniel C. Link, Pavan R. Reddy, Ivan Maillard, Timothy J. Ley, Todd A. Fehniger, Melissa M. Berrien-Elliott, Nishi Parikh, Gloria Jih, Yaping Sun, Jack Baty, Iris Kuo, Rahul Ramaswamy, Juo-Chin Yao, Terrence N. Wong, Maria C. Trissal
Point mutations in the seed sequence of miR-142-3p are present in a subset of acute myelogenous leukemia (AML) and in several subtypes of B-cell lymphoma. Here, we show that mutations associated with AML result both in loss of miR-142-3p function and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00d20bec30bf22003c8bc9e136e811dc
https://doi.org/10.1158/0008-5472.c.6510407.v1
https://doi.org/10.1158/0008-5472.c.6510407.v1
Autor:
Sidan Li, Juo-Chin Yao, Karolyn A. Oetjen, Joseph R. Krambs, Jun Xia, Jingzhu Zhang, Amy P. Schmidt, Nichole M. Helton, Robert S. Fulton, Sharon E. Heath, Isaiah R. Turnbull, Gabriel Mbalaviele, Timothy J. Ley, Matthew J. Walter, Daniel C. Link
Publikováno v:
Blood. 140(14)
Hematopoietic stem/progenitor cells (HSPCs) reside in localized microenvironments, or niches, in the bone marrow that provide key signals regulating their activity. A fundamental property of hematopoiesis is the ability to respond to environmental cu
Autor:
Juo-Chin Yao, Karolyn A. Oetjen, Tianjiao Wang, Haoliang Xu, Grazia Abou-Ezzi, Joseph R. Krambs, Salil Uttarwar, Eric J. Duncavage, Daniel C. Link
Publikováno v:
The Journal of clinical investigation. 132(11)
Myeloproliferative neoplasms (MPNs) are associated with significant alterations in the bone marrow microenvironment that include decreased expression of key niche factors and myelofibrosis. Here, we explored the contribution of TGF-β to these altera
Publikováno v:
Exp Hematol
There is accumulating evidence suggesting that toll-like receptor (TLR) signals play an important role in the regulation of hematopoietic stem/progenitor cells (HSPCs). TLR7/8 stimulation induces the myeloid differentiation of normal HSPCs and acute