Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Junzo TAKAHASHI"'
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:175-183
In the search for orally available drugs, the prediction of human pharmacokinetics (PK) is essential for successfully selecting compounds that will be clinically useful. This report describes the selection of TAK-272 (SCO-272), a novel orally active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8586da206cabc109969d5e1e456e9597
https://doi.org/10.1002/bdd.2124
https://doi.org/10.1002/bdd.2124
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 122:577-587
TAK-063 is currently being developed to treat schizophrenia. In this study, we investigated the absorption, distribution, metabolism and excretion (ADME) properties of TAK-063 using several paradigms. Following oral administration of TAK-063 at 0.3 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b238bf084d9cf7b24bbe832d76f68fa7
https://doi.org/10.1111/bcpt.12964
https://doi.org/10.1111/bcpt.12964
Publikováno v:
Drug Metabolism and Disposition. 45:734-736
We evaluated the long-term stability of hepatocytes stored in the vapor phase of liquid nitrogen for their viability, cytochrome P450 (CYP) 1A2 activity, CYP3A4/5 activity, uridine diphosphate-glucuronosyl transferase (UGT) activity, sulfotransferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1f5f4e742dfb1e0e37c93abbeed303
https://doi.org/10.1124/dmd.117.075234
https://doi.org/10.1124/dmd.117.075234
Publikováno v:
Biopharmaceuticsdrug disposition. 39(3)
In the search for orally available drugs, the prediction of human pharmacokinetics (PK) is essential for successfully selecting compounds that will be clinically useful. This report describes the selection of TAK-272 (SCO-272), a novel orally active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52a6fc1bf3414c2cf712feefb40de195
https://pubmed.ncbi.nlm.nih.gov/29474740
https://pubmed.ncbi.nlm.nih.gov/29474740
Autor:
Yohei Kosugi, Junzo Takahashi
Publikováno v:
Xenobiotica. 45:345-352
1. The purpose of this study was to clarify species differences in the heteroactivation of CYP3A substrates by efavirenz, which is known from clinical studies to activate midazolam 1'-hydroxylation, and to assess the feasibility of an animal model. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3dd80c85bd860aa9f34e6579aff68e
https://doi.org/10.3109/00498254.2014.981610
https://doi.org/10.3109/00498254.2014.981610
Autor:
Hitomi Yamasaki, Naohiro Kawaguchi, Junzo Takahashi, Satoru Asahi, Hideki Hirabayashi, Akio Morohashi, Masami Nonaka, Toshiya Moriwaki
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 47(12)
1. TAK-438, vonoprazan fumarate, is a novel orally active potassium-competitive acid blocker, developed as an antisecretory drug. In this study, we investigated the in vitro metabolism of 14C-labeled TAK-438. In human hepatocytes, M-I, M-II, M-III an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1a6e4602c43e51a2d900ef9578e053
https://pubmed.ncbi.nlm.nih.gov/27414183
https://pubmed.ncbi.nlm.nih.gov/27414183
Autor:
Masami Kusaka, Junzo Takahashi, Masuo Yamaoka, Satoru Asahi, Takahito Hara, Takenori Hitaka, Tomohiro Kaku, Toshiyuki Takeuchi, Hiroshi Miki, Akihiro Tasaka
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 129:115-128
Surgical or pharmacologic methods to control gonadal androgen biosynthesis are effective approaches in the treatment of a variety of non-neoplastic and neoplastic diseases. For example, androgen ablation and its consequent reduction in circulating le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e25cb51d6b392d67dbb96e8b943c392
https://doi.org/10.1016/j.jsbmb.2012.01.001
https://doi.org/10.1016/j.jsbmb.2012.01.001
Autor:
Junzo Takahashi, Miyako Sudo, Yutaka Kiyota, Takahiro Kondo, Satoru Asahi, Naohiro Kawaguchi, Mitsuhiro Nishihara
Publikováno v:
Drug Metabolism and Disposition. 40:249-258
Animal pharmacokinetic studies of sipoglitazar, a novel antidiabetic agent, showed that the deethylated metabolite (M-I) and the glucuronide conjugate of sipoglitazar (sipoglitazar-G) appeared to be the key metabolites in the elimination process. M-I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45de8be8e2e80eb747aff48bd0d2d86e
https://doi.org/10.1124/dmd.111.040105
https://doi.org/10.1124/dmd.111.040105
Autor:
Masayuki Taira, R. Ito, Satoru Toyosawa, Junzo Takahashi, Masayuki Okazaki, Yoshinosuke Hamada, M. S. Toguchi, N. Ijyuin
Publikováno v:
Journal of Oral Rehabilitation. 27:1068-1072
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e859da44a7225907801154536cb71bd
https://doi.org/10.1111/j.1365-2842.2000.00608.x
https://doi.org/10.1111/j.1365-2842.2000.00608.x
Publikováno v:
Journal of Oral Rehabilitation. 24:527-531
summary Some dental prostheses are formed by machining. The purpose of this study was to evaluate the dental high-speed cutting behaviour of free-machining titanium (Ti), the ease in cutting of which is metallurgically improved. Weight-load cutting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83c928a88ac80c8f3e427af75a4c3df
https://doi.org/10.1111/j.1365-2842.1997.tb00369.x
https://doi.org/10.1111/j.1365-2842.1997.tb00369.x