Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Junzo Nakamura"'
Autor:
Eriko Kinoshita, Shintaro Fumoto, Yuta Hori, Naoki Yoshikawa, Hirotaka Miyamoto, Hitoshi Sasaki, Junzo Nakamura, Takashi Tanaka, Koyo Nishida
Publikováno v:
Biotechnology Reports, Vol 24, Iss , Pp - (2019)
In this study, we have developed a novel method to monitor transgene expression in tissues by blood sampling. We administered plasmid DNA (pDNA) encoding non-secretory form of firefly luciferase as a reporter gene and pDNA encoding secretable Gaussia
Externí odkaz:
https://doaj.org/article/a4a97bc9288f45758e0ee8d33aacca2a
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 14, Iss 2 (2011)
Purpose. We previously demonstrated liver- and lobe-selective gene transfer following instillation of plasmid DNA (pDNA) onto the liver surface in mice. Safety concerns must be resolved prior to future clinical use. Thus, we investigated safety of li
Externí odkaz:
https://doaj.org/article/5c4b159a9567419eae1b4e63c5dcdc35
Autor:
Tomoaki Kurosaki, Takashi Kitahara, Mugen Teshima, Koyo Nishida, Junzo Nakamura, Mikiro Nakashima, Hideto To, Hiromitsu Hukuchi, Tomoyuki Hamamoto, Hitoshi Sasaki
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 11, Iss 4 (2009)
Purpose: In gene delivery, a fusogenic lipid such as dioleyl phosphatidylethanolamine (DOPE) which is a component of cationic liposomal vector is important factor for effective transfection efficiency. We investigated the effect of penetration enhanc
Externí odkaz:
https://doaj.org/article/389b5a1c1d534229b018f89336765923
Autor:
Giovanna Porfilio Gularte, Romina Parquet, Junzo Nakamura, Mario Bugallo, Rossanna Alegre, Junichi Gabriel Nakamura
Publikováno v:
Acta Gastroenterológica Latinoamericana, Vol 35, Iss 4, p 206 (2005)
Externí odkaz:
https://doaj.org/article/cbcf886f4dc3493885d8bc5b34a306e4
Autor:
Hirotaka Miyamoto, Yukinobu Kodama, Shintaro Fumoto, Koyo Nishida, Miyuki Horishita, Ayako Tokunaga, Hitoshi Sasaki, Junzo Nakamura
Publikováno v:
Biopharmaceutics & Drug Disposition. 38:367-372
This study investigated the effect of epinephrine (a vasoconstrictor) and hydralazine (a vasodilator) on the hepatic disposition of 5-fluorouracil (5-FU) after application to the surface of the liver in rats. Normal livers were compared with a Walker
Autor:
Takashi Tanaka, Koyo Nishida, Shintaro Fumoto, Naoki Yoshikawa, Junzo Nakamura, Hirotaka Miyamoto, Hitoshi Sasaki, Eriko Kinoshita, Yuta Hori
Publikováno v:
Biotechnology Reports, Vol 24, Iss, Pp-(2019)
Biotechnology Reports
Biotechnology Reports
Highlights • Transgene expressions of simultaneously-administered two plasmid DNA in muscle correlated each other. • Transgene expressions of secretable luciferase in muscle and plasma also correlated each other. • It was possible to monitor tr
Autor:
Junzo Nakamura, Hirotaka Miyamoto, Shintaro Fumoto, Hitoshi Sasaki, Naoki Yoshikawa, Toyoharu Mine, Koyo Nishida
Publikováno v:
Scopus-Elsevier
The purpose of this study is to improve the rate at which drugs are absorbed from the liver surface by utilizing absorption enhancers such as extracted saponin from Saponaria officinalis (saponin), sodium caprate (Na-Cap), sodium salicylate (Na-Sal),
Autor:
Hirotaka Miyamoto, Yukinobu Kodama, Junzo Nakamura, Toyoharu Mine, Miyuki Horishita, Koyo Nishida, Shintaro Fumoto, Hitoshi Sasaki, Naoki Yoshikawa, Haruna Hirata
Publikováno v:
Journal of Pharmacy and Pharmacology. 64:1438-1444
Objectives The aim was to study the effect of viscous additives on the absorption and hepatic disposition of 5-fluorouracil (5-FU) after application to the liver surface in rats. Methods 5-FU solution with or without viscous additives was applied to
Autor:
Junzo Nakamura, Koyo Nishida, Hirotaka Miyamoto, Yuichi Ohwaki, Hitoshi Sasaki, Haruna Hirata, Hideaki Miyake, Shintaro Fumoto, Naoki Yoshikawa
Publikováno v:
Journal of Pharmacy and Pharmacology. 64:848-854
Objectives The aim of this study was to determine the factor changing the hepatic disposition of a drug during hypothermia using a rat liver perfusion system. Methods The livers of male Wistar rats were perfused at 37, 32 or 28°C in the single-pass
Autor:
Yasuko Mizukami, Tetsuya Ueki, Koyo Nishida, Mikiro Nakashima, Mihoko N. Nakashima, Junzo Nakamura, Nobuharu Ooe, Keiko Nagai, Akihiro Takahashi
Publikováno v:
YAKUGAKU ZASSHI = 薬学雑誌. 131(8):1225-1232
Constipation can be caused by adverse drug reactions as a result of many drugs and might be induced by sleep disorders; however, the relative risk of its occurrence with individual drugs and the influence of sleep conditions have not been clarified.