Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Junyu Xiao"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract CD5 antigen-like (CD5L), also known as Spα or AIM (Apoptosis inhibitor of macrophage), emerges as an integral component of serum immunoglobulin M (IgM). However, the molecular mechanism underlying the interaction between IgM and CD5L has re
Externí odkaz:
https://doaj.org/article/d26dba1b6df74312a8b940a79ef2cb4b
Autor:
Xiao Niu, Zhiqiang Li, Jing Wang, Fanchong Jian, Yuanling Yu, Weiliang Song, Ayijiang Yisimayi, Shuo Du, Zhiying Zhang, Qianran Wang, Ran An, Yao Wang, Peng Wang, Haiyan Sun, Lingling Yu, Sijie Yang, Tianhe Xiao, Qingqing Gu, Fei Shao, Youchun Wang, Junyu Xiao, Yunlong Cao
Publikováno v:
Emerging Microbes and Infections (2024)
A multitude of functional mutations continue to emerge on the N-terminal domain (NTD) of the spike protein in SARS-CoV-2 Omicron subvariants. Understanding the immunogenicity of Omicron NTD and the properties of antibodies elicited by it is crucial f
Externí odkaz:
https://doaj.org/article/8e6927d6bbab41f59fa63f324f3ab0ce
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The study of phosphorylase kinase (PhK)-regulated glycogen metabolism has contributed to the fundamental understanding of protein phosphorylation; however, the molecular mechanism of PhK remains poorly understood. Here we present the high-re
Externí odkaz:
https://doaj.org/article/a421c25480244faf992384e1ec1bc657
Autor:
Jun Yang, Kai Liang, Han Ke, Yuebin Zhang, Qian Meng, Lei Gao, Junping Fan, Guohui Li, Hu Zhou, Junyu Xiao, Xiaoguang Lei
Publikováno v:
JACS Au, Vol 4, Iss 2, Pp 619-634 (2024)
Externí odkaz:
https://doaj.org/article/c8bd3363782049089bc8e4a9c629b4b0
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as the first line of humoral defense against infection and potently activates the complement pathway to facilitate P. falciparum clearance. A numbe
Externí odkaz:
https://doaj.org/article/a62734877f434c9ab37f367a1cf3ab19
Autor:
Yanyun Du, Rui Shi, Ying Zhang, Xiaomin Duan, Li Li, Jing Zhang, Fengze Wang, Ruixue Zhang, Hao Shen, Yue Wang, Zheng Wu, Qianwen Peng, Ting Pan, Wanwei Sun, Weijin Huang, Yue Feng, Hui Feng, Junyu Xiao, Wenjie Tan, Youchun Wang, Chenhui Wang, Jinghua Yan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Here the authors report the isolation and structural and biological characterization of a humanized angiotensin-converting enzyme 2 (ACE2)-blocking antibody, which exterts potent inhibitory activity against SARS-CoV and circulating global SARS-CoV-2
Externí odkaz:
https://doaj.org/article/97a9b5fb5db54f02ba7db4036da85f1f
Autor:
Xiaomin Duan, Rui Shi, Pulan Liu, Qingrui Huang, Fengze Wang, Xinyu Chen, Hui Feng, Weijin Huang, Junyu Xiao, Jinghua Yan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/9eed9bddfa3849e8b1c94d131a7b3c93
Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry
Autor:
Tiantian Wei, Jue Wang, Ruqi Liang, Wendong Chen, Yilan Chen, Mingzhe Ma, An He, Yifei Du, Wenjing Zhou, Zhiying Zhang, Xin Zeng, Chu Wang, Jin Lu, Xing Guo, Xiao-Wei Chen, Youjun Wang, Ruijun Tian, Junyu Xiao, Xiaoguang Lei
Publikováno v:
eLife, Vol 11 (2022)
The dual-specificity tyrosine phosphorylation-regulated kinase DYRK2 has emerged as a critical regulator of cellular processes. We took a chemical biology approach to gain further insights into its function. We developed C17, a potent small-molecule
Externí odkaz:
https://doaj.org/article/d371ca8cabea45129010611a2413de8e
Autor:
Ameya S Walimbe, Hidehiko Okuma, Soumya Joseph, Tiandi Yang, Takahiro Yonekawa, Jeffrey M Hord, David Venzke, Mary E Anderson, Silvia Torelli, Adnan Manzur, Megan Devereaux, Marco Cuellar, Sally Prouty, Saul Ocampo Landa, Liping Yu, Junyu Xiao, Jack E Dixon, Francesco Muntoni, Kevin P Campbell
Publikováno v:
eLife, Vol 9 (2020)
Matriglycan [-GlcA-β1,3-Xyl-α1,3-]n serves as a scaffold in many tissues for extracellular matrix proteins containing laminin-G domains including laminin, agrin, and perlecan. Like-acetyl-glucosaminyltransferase 1 (LARGE1) synthesizes and extends m
Externí odkaz:
https://doaj.org/article/17d3f0ccf58a40a8a791f30363198f9e
Autor:
Hui Zhang, Qinyu Zhu, Jixin Cui, Yuxin Wang, Mark J. Chen, Xing Guo, Vincent S. Tagliabracci, Jack E. Dixon, Junyu Xiao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Fam20 proteins are kinases that phosphorylate secreted proteins and proteoglycans. Here the authors present the crystal structures of the three Fam20 kinases and their complexes and give mechanistic insights into substrate recognition and the functio
Externí odkaz:
https://doaj.org/article/17af4b3603344b87a364eec04b64111a