Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Junyong Jo"'
Autor:
Kazunori Koide, Matthew P. Tracey, Xiaodong Bu, Junyong Jo, Michael J. Williams, Christopher J. Welch
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Assays for catalytic systems—particularly ones with simple colorimetric readouts—are useful for the rapid evaluation of performance. Here, the authors report an assay based on a concurrent colour-forming reaction working across a wide range that
Externí odkaz:
https://doaj.org/article/88ede78a15cf479996151da1c13b993b
Autor:
Matthew J. Gunsch, Erica L. Schwalm, Claire M. Ouimet, Holst M. Halsey, Simon E. Hamilton, Frank Bernardoni, Junyong Jo
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 213
Biocatalytic processes have become more prevalent in the pharmaceutical industry, leading to analytical challenges not faced when characterizing more traditional synthetic routes. A novel one-pot biocatalytic process has been established for Islatrav
Autor:
Edward C. Sherer, Junyong Jo, Holst M. Halsey, Jack Liang, Niki R. Patel, Agustina Rodriguez-Granillo, Christopher C. Nawrat, Aaron M. Whittaker, Canada Keith A, Margie Borra-Garske, Nicholas M. Marshall, Kevin R. Campos, Anna Fryszkowska, Yingju Xu, Paul N. Devine, Shane T. Grosser, Grant S. Murphy, Jovana Nazor, Matthew D. Truppo, Benjamin F. Mann, Jeffrey C. Moore, Sandra A. Robaire, Gregory Hughes, Scott J. Novick, Da Duan, Jacob Forstater, Joshua N. Kolev, Deeptak Verma, Kevin M. Maloney, Oscar Alvizo, Mark A. Huffman, Li Xiao, Mark McLaughlin, Leo A. Joyce, Hao Yang
Publikováno v:
Science. 366:1255-1259
Maximal efficiency from enzyme cascades Enzymes are highly selective catalysts that can be useful for specific transformations in organic synthesis. Huffman et al. combined designer enzymes in a multistep cascade reaction (see the Perspective by O'Re
Autor:
Jiyoung Jung, Junyong Jo
Publikováno v:
Organic Process Research & Development. 23:1257-1261
A novel copper specific colorimetric probe molecule was developed which shows rapid response and low detection limit. Proof-of-concept for high-throughput analysis is demonstrated utilizing flow in...
Autor:
Guangtao Li, Hong Ren, Kevin M. Maloney, Junyong Jo, Xiaodong Bu, Xiaoyi Gong, Justin A. Newman, Lanfang Zou, Rong Xiang, Qiang Tu
Publikováno v:
Organometallics. 38:185-193
Transition metal catalysts in pharmaceutical processes is widely used, but health care agencies such as the Food and Drug Administration and the European Medicines Agency highly regulate the residual level of elemental impurities in the final drug su
Publikováno v:
Organic Process Research & Development. 21:1689-1693
Oxidative cyclization of o-phenylazo aniline was utilized as a turn-on fluorescent probe of the copper(II) ion. The number and the position of electron donating groups on the probes were systematically varied to investigate the effect of aryl substit
Autor:
Nathan D. Contrella, Chandan L. Barhate, Christopher J. Welch, Daniel W. Armstrong, Erik L. Regalado, Alexey A. Makarov, Joon Lee, Junyong Jo
Publikováno v:
Analytical Chemistry. 89:3545-3553
Chromatographic separation and analysis of complex mixtures of closely related species is one of the most challenging tasks in modern pharmaceutical analysis. In recent years, two-dimensional liquid chromatography (2D-LC) has become a valuable tool f
Publikováno v:
Organic Letters. 18:4530-4533
A conformationally twisted N-arylbenzotriazole was designed as a fluorescence turn-on molecular probe. Under ambient conditions, metal-catalyzed deallylation reactions restore an intense blue emission. This reaction scheme is applicable exclusively t
Publikováno v:
Chemical communications (Cambridge, England). 53(4)
Rapid palladium (Pd) catalyzed deallylation of an uncoloured reagent within a flowing stream affords a dose dependent colour formation that can be used for convenient online analysis of trace levels of Pd contamination using a modified HPLC instrumen
Autor:
Michael Williams, Matthew P. Tracey, Christopher J. Welch, Kazunori Koide, Xiaodong Bu, Junyong Jo
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Catalysis-based signal amplification makes optical assays highly sensitive and widely useful in chemical and biochemical research. However, assays must be fine-tuned to avoid signal saturation, substrate depletion and nonlinear performance. Furthermo