Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Junying Yuan"'
Autor:
Shenjin Chen, Junying Yuan
Publikováno v:
IEEE Access, Vol 12, Pp 59665-59679 (2024)
To solve the conflict of interests between citizens’ travel and public transportation enterprises, and alleviate the pressure of passenger flow at morning and evening peak bus stop, a multimodal combination optimization model for public transportat
Externí odkaz:
https://doaj.org/article/effdf585bf954bbcbbf98788a20510ad
Autor:
Jun Wei, Min Li, Zhi Ye, Xinqian Hu, Xiaoyan He, Jia Wang, Gaofeng Chen, Chengyu Zou, Daichao Xu, Hongbing Zhang, Junying Yuan, Yunhong Zha
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-8 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a devastating fatal neurodegenerative disease with no cure. Receptor-interacting protein kinase 1 (RIPK1) has been proposed to mediate pathogenesis of ALS. Primidone has been identified as an old drug t
Externí odkaz:
https://doaj.org/article/fd2d653320c74250abdbdb166c739388
Publikováno v:
IEEE Access, Vol 11, Pp 135905-135914 (2023)
Devices equipped with algorithms for detecting infant cries allow parents to respond immediately to their crying babies. However, improving detection performance often requires complex algorithms that consume more computing resources, leading to incr
Externí odkaz:
https://doaj.org/article/5e3b157932cd44eca0626eb72b7129e6
Autor:
Juan Li, Yang Wang, Yue Luo, Yang Liu, Yong Yi, Jinsong Li, Yang Pan, Weiyuxin Li, Wanbang You, Qingyong Hu, Zhiqiang Zhao, Yujun Zhang, Yang Cao, Lingqiang Zhang, Junying Yuan, Zhi-Xiong Jim Xiao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Oncogene-induced senescence (OIS) occurs in premalignant lung adenomas, but infrequently in malignant adenocarcinomas. Here the authors show that USP5-Beclin 1 axis overcomes OIS in Kras-driven lung cancer by enhancing MDM2-mediated p53 degradation.
Externí odkaz:
https://doaj.org/article/ebc13f65f36f4c69b937f3af1729c65e
Autor:
Guowei Wu, Dekang Li, Wei Liang, Weimin Sun, Xingxing Xie, Yilun Tong, Bing Shan, Mengmeng Zhang, Xiaojuan Lu, Junying Yuan, Ying Li
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-14 (2022)
Abstract Activation of TNFR1 by TNFα induces the formation of a membrane-associated, intracellular complex termed complex I. Complex I orchestrates a complex pattern of modifications on key regulators of TNF signaling that collectively determines th
Externí odkaz:
https://doaj.org/article/b0e40f33ed404a358026112134298f31
Autor:
Wanjin Li, Junying Yuan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) is a master regulator of TNFR1 signaling in controlling cell death and survival. While the scaffold of RIPK1 participates in the canonical NF-κB pathway, the activation of RIPK1 kinase p
Externí odkaz:
https://doaj.org/article/c470a6d25f124dea81012cc97e35ec1d
Autor:
Rui Zu, Zhen Yu, Jing Zhao, Xiaojuan Lu, Wei Liang, Le Sun, Chenfang Si, Kezhou Zhu, Tian Zhang, Ganquan Li, Mengmeng Zhang, Yaoyang Zhang, Nan Liu, Junying Yuan, Bing Shan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Abstract Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oligomerization and execution of ne
Externí odkaz:
https://doaj.org/article/70ad286ccd1f4e56af15db5ed08e7b33
Autor:
Huibing Wang, Weiwei Qi, Chengyu Zou, Zhangdan Xie, Mengmeng Zhang, Masanori Gomi Naito, Lauren Mifflin, Zhen Liu, Ayaz Najafov, Heling Pan, Bing Shan, Ying Li, Zheng-Jiang Zhu, Junying Yuan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
NEK1 mutations promote lethality early in life and ALS late in life via unknown mechanisms. Here, the authors show that NEK1 mutation disrupts retromer-mediated trafficking and promotes RIPK1 activation, connecting retromer trafficking and metabolism
Externí odkaz:
https://doaj.org/article/4294aac17a8b4f399739cdbf82ea2a17
Autor:
Huyan Meng, Guowei Wu, Xinsuo Zhao, Anhui Wang, Dekang Li, Yilun Tong, Taijie Jin, Ye Cao, Bing Shan, Shichen Hu, Ying Li, Lifeng Pan, Xiaoxu Tian, Ping Wu, Chao Peng, Junying Yuan, Guohui Li, Li Tan, Zhaoyin Wang
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-18 (2021)
Abstract RIPK1, a death domain-containing kinase, has been recognized as an important therapeutic target for inhibiting apoptosis, necroptosis, and inflammation under pathological conditions. RIPK1 kinase inhibitors have been advanced into clinical s
Externí odkaz:
https://doaj.org/article/933cebcdfc1c4ca5a3e8adfa7b6a2bbb
Autor:
Xingyan Li, Mengmeng Zhang, Xinyue Huang, Wei Liang, Ganquan Li, Xiaojuan Lu, Yanxia Li, Heling Pan, Linyu Shi, Hong Zhu, Lihui Qian, Bing Shan, Junying Yuan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
RIPK1 is a critical kinase which mediates necroptosis, apoptosis and inflammation. Regulation of RIPK1 by ubiquitination is being intensively investigated. Here, the authors made knock-in RIPK1-K612R mice and demonstrate that this mutation alters the
Externí odkaz:
https://doaj.org/article/13104a8bcb9e4fa4a4030c31c509ba7c