Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Junyi Pu"'
TJP1, a Membrane-Expressed Protein, is a Potential Therapeutic and Prognostic Target for Lung Cancer
Publikováno v:
Technology in Cancer Research & Treatment, Vol 21 (2022)
Objective: Lung cancer is a malignant tumor with the highest mortality rate in the world. It is necessary to develop effective biomarkers for diagnosis or prognostic treatment to improve the survival rate of patients. In this prospective study, we id
Externí odkaz:
https://doaj.org/article/a142171d4f62468a8bda721c2f027a23
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 48, Iss 1, Pp 639-647 (2020)
Paclitaxel (PTX), a tubulin-binding agent, is widely used and has shown good efficacy in the initial period of treatment for non-small cell lung cancer (NSCLC). However, the relatively rapid acquisition of resistance to PTX treatments that is observe
Externí odkaz:
https://doaj.org/article/7ff7f7e6943b4aa5bfdcb1fb92bc6431
Autor:
Xun Meng, Wenhao Hu, Shu-Hui Liu, Yu Qian, Guoqiang Hua, Yi Peter Hu, Jianjian Zhang, Junyi Pu, Hui Zhang, Biao Zhou, Lijun Wang, Caiwei Chen, Linjie Ma, Rong Pan, Mingqiao Wang, Zhaohui Wang, Yue Zhang, Jing Shi, Guoxiang Fu, Yi Shen, Qianqian Zhao, Tao Meng, Weining Weng
Supplementary Figure S1 shows Exatecan cytotoxicity and sensitivity to multidrug resistant genes. Supplementary Figure S2 shows Exatecan and DXd/SN-38 sensitivity to multidrug resistant genes. Supplementary Figure S3 shows Exatecan toxicity in rat. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ce6bdaea1330850b6fd2c3b851fe07
https://doi.org/10.1158/2159-8290.22553455.v1
https://doi.org/10.1158/2159-8290.22553455.v1
Autor:
Xun Meng, Wenhao Hu, Shu-Hui Liu, Yu Qian, Guoqiang Hua, Yi Peter Hu, Jianjian Zhang, Junyi Pu, Hui Zhang, Biao Zhou, Lijun Wang, Caiwei Chen, Linjie Ma, Rong Pan, Mingqiao Wang, Zhaohui Wang, Yue Zhang, Jing Shi, Guoxiang Fu, Yi Shen, Qianqian Zhao, Tao Meng, Weining Weng
Supplementary note shows the analytical characterization of the ADCs, and synthesis of drug-linkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bfe40e4106b1e91b818c166ebebc5f
https://doi.org/10.1158/2159-8290.22553452
https://doi.org/10.1158/2159-8290.22553452
Autor:
Xun Meng, Wenhao Hu, Shu-Hui Liu, Yu Qian, Guoqiang Hua, Yi Peter Hu, Jianjian Zhang, Junyi Pu, Hui Zhang, Biao Zhou, Lijun Wang, Caiwei Chen, Linjie Ma, Rong Pan, Mingqiao Wang, Zhaohui Wang, Yue Zhang, Jing Shi, Guoxiang Fu, Yi Shen, Qianqian Zhao, Tao Meng, Weining Weng
Supplementary Table S1 shows cytotoxicity of exatecan compared to DXd. Supplementary Table S2 shows selected hematologic parameters and biochemical parameters from the repeat-dose administration of exatecan mesylate studies in rats. Supplementary Tab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c3030dcc4f49fa87088a68b94ff786
https://doi.org/10.1158/2159-8290.22553449.v1
https://doi.org/10.1158/2159-8290.22553449.v1
Autor:
Xun Meng, Wenhao Hu, Shu-Hui Liu, Yu Qian, Guoqiang Hua, Yi Peter Hu, Jianjian Zhang, Junyi Pu, Hui Zhang, Biao Zhou, Lijun Wang, Caiwei Chen, Linjie Ma, Rong Pan, Mingqiao Wang, Zhaohui Wang, Yue Zhang, Jing Shi, Guoxiang Fu, Yi Shen, Qianqian Zhao, Tao Meng, Weining Weng
Antibody–drug conjugates (ADC) using DNA topoisomerase I inhibitor DXd/SN-38 have transformed cancer treatment, yet more effective ADCs are needed for overcoming resistance. We have designed an ADC class using a novel self-immolative T moiety for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1001d2baf053a41af37a7c38feee09
https://doi.org/10.1158/2159-8290.c.6534720.v1
https://doi.org/10.1158/2159-8290.c.6534720.v1
Publikováno v:
Genes; Volume 13; Issue 5; Pages: 862
Molecular prognosis markers hold promise for improved prediction of patient survival, and a pathway or gene set may add mechanistic interpretation to their prognostic prediction power. In this study, we demonstrated a novel strategy to identify progn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d1bee0b37943e4aaa746a4cf88fbdf
https://pubmed.ncbi.nlm.nih.gov/35627247
https://pubmed.ncbi.nlm.nih.gov/35627247
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology. 48:639-647
Paclitaxel (PTX), a tubulin-binding agent, is widely used and has shown good efficacy in the initial period of treatment for non-small cell lung cancer (NSCLC). However, the relatively rapid acquis...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82b144074b5cc32a4f479d0544053f25
https://doi.org/10.1080/21691401.2020.1728287
https://doi.org/10.1080/21691401.2020.1728287
Autor:
Hui Liang, Chao Chen, Yamin Wang, Jianfeng Shen, Penggao Dai, Junyi Pu, Linna Liu, Xun Wang, Shaojia Wen
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology. 46:896-905
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. 5-fluorouracil (5-FU)-based chemotherapeutic regimens are routinely used for the treatment of patients with CRC. However, recurrence and chemotherapeutic drug resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9eaaa81dfb2e301718011e9d2a5b7f
https://doi.org/10.1080/21691401.2018.1439835
https://doi.org/10.1080/21691401.2018.1439835
Autor:
Jianfeng Shen, Xun Wang, Xin Men, Penggao Dai, Yamin Wang, Tong Wu, Junyi Pu, Jun Ma, Chao Chen, Shaojia Wen
Publikováno v:
Oncotarget
Tamoxifen (TAM) resistance is an important clinical problem in the treatment of breast cancer. In order to identify the mechanism of TAM resistance for estrogen receptor (ER)-positive breast cancer, we screened the transcriptome using RNA-seq and com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161ecef820523ddd922d20027246ae91
https://doi.org/10.18632/oncotarget.23694
https://doi.org/10.18632/oncotarget.23694