Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Junyan A Ji"'
Autor:
Kai Zheng, Diya Ren, Y. John Wang, Wayne Lilyestrom, Thomas Scherer, Justin K. Y. Hong, Junyan A. Ji
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3952 (2021)
Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact product efficacy and patient safety. In this work, we used 2,2′-azobis (2-amidinopropane)
Externí odkaz:
https://doaj.org/article/e4a9f9583ec54a609836950196e707ce
Autor:
Junyan A Ji, Y John Wang, Kai Zheng, Justin K Y Hong, Diya Ren, Wayne Lilyestrom, Thomas M. Scherer
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3952, p 3952 (2021)
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3952, p 3952 (2021)
Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact product efficacy and patient safety. In this work, we used 2,2′-azobis (2-amidinopropane)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d2d69f2f72850333e44c5e3c419abd
https://pubmed.ncbi.nlm.nih.gov/33921206
https://pubmed.ncbi.nlm.nih.gov/33921206
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 70:332-345
Degradation of the surfactant polysorbate (PS) by enzyme impurities has been previously suggested as a mechanism for the formation of visible and subvisible particles that affect product quality. Although chemical degradation pathways of PS, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6812c7d2b278ac7e28fbdb83269f0660
https://doi.org/10.5731/pdajpst.2015.005942
https://doi.org/10.5731/pdajpst.2015.005942
Publikováno v:
Molecular Pharmaceutics. 10:739-755
The oxidation of PTH(1-34) catalyzed by ferrous ethylenediaminetetraacetic acid (EDTA) is site-specific. The oxidation of PTH(1-34) is localized primarily to the residues Met[8] and His[9]. Beyond the transformation of Met[8] and His[9] into methioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cbfb6af215f62882ec9226691e068a
https://doi.org/10.1021/mp300563m
https://doi.org/10.1021/mp300563m
Autor:
Tingting Wang, C. Russell Middaugh, Ozan S. Kumru, Junyan A. Ji, Wilson Cheng, Sangeeta B. Joshi, Jun Liu, David B. Volkin, Y. John Wang
Publikováno v:
Journal of Pharmaceutical Sciences. 101:3636-3650
The physical stability of an immunoglobulin G4 monoclonal antibody (mAb) upon dilution into intravenous (i.v.) bags containing 0.9% saline was examined. Soluble aggregates and subvisible particles were observed by size-exclusion high-performance liqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30c32bd84f65050622bd270544935ce
https://doi.org/10.1002/jps.23224
https://doi.org/10.1002/jps.23224
Publikováno v:
Journal of Pharmaceutical Sciences. 100:3307-3315
2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH), a free radical-generating azo compound, is gaining prominence as a model oxidant in small molecule and protein therapeutics, namely for its ability to initiate oxidation reactions via both nucleop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfcc7a473ba6d99b9d94f5ddf002d5c
https://doi.org/10.1002/jps.22578
https://doi.org/10.1002/jps.22578
Publikováno v:
Journal of Pharmaceutical Sciences. 100:1341-1349
The physicochemical stability of protein therapeutics is of significant pharmaceutical interest. Immunoglobulin gamma (IgG) hinge region fragmentation has recently garnered attention as an important degradation route of therapeutic monoclonal antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7e9ba38a20d0e09cf73a7b564400ed
https://doi.org/10.1002/jps.22389
https://doi.org/10.1002/jps.22389
Publikováno v:
AAPS PharmSciTech. 10:678-683
Methylcellulose and hydroxypropylmethylcellulose (hypromellose) are used in topical formulations of a protein to form a viscous hydrogel. Five lots of hypromellose raw material were made into 3% gel; all showed viscosity loss after sterilization by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84e5d9db5296f8cb09fdbd7af440928
https://doi.org/10.1208/s12249-009-9258-6
https://doi.org/10.1208/s12249-009-9258-6
Publikováno v:
Antibody-Drug Conjugates ISBN: 9783319130804
Antibody–drug conjugates (ADCs) are complex molecules designed to provide targeted therapy to cancer patients. An ADC is formed commonly by conjugating an antibody with small cytotoxic drugs generally either through lysine e-amino groups to form a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::017a6b42f85181a54f3355d3b2cbbf06
https://doi.org/10.1007/978-3-319-13081-1_5
https://doi.org/10.1007/978-3-319-13081-1_5
Publikováno v:
Journal of pharmaceutical sciences. 104(3)
Polysorbates (PSs), as acquired from manufacturing processes and chemical nature of fatty acids (FAs) used in production of biotherapeutic formulations, are heterogeneous mixtures of structurally related compounds, covering a wide range of physicoche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e795fcfe1254e0eefb0c2d0988eb3ca0
https://pubmed.ncbi.nlm.nih.gov/25581232
https://pubmed.ncbi.nlm.nih.gov/25581232