Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Junya Uwayama"'
Autor:
Richard C.M. Siow, Giovanni E. Mann, Hiroki Bukawa, Tetsuro Ishii, Kazuhiro Nakaso, Eiji Warabi, Junichi Shoda, Harumi Harada, Kosuke Okada, Kyoko Kirii, Akira Ikeda, Taizo Matsuki, Takeshi Sakurai, Toru Yanagawa, Noriko Noguchi, Junya Uwayama
Publikováno v:
The Journal of Neuroscience. 33:14767-14777
The cytoplasmic regulatory protein p62 (Sequestosome 1/A170) is known to modulate various receptor-mediated intracellular signaling pathways.p62deficiency was shown to result in mature-onset obesity in mice, but the mechanisms underlying this abnorma
Autor:
Satoru Katayanagi, Tetsuro Ishii, Kiyoshi Kitamura, Noriko Noguchi, Giovanni E. Mann, Ayaka Watanabe, Eiji Warabi, Satoshi Sakai, Harumi Harada, Hiroshi Yoshida, Rika Sugimoto, Junya Uwayama, Toru Yanagawa, Richard C.M. Siow
Publikováno v:
Journal of Cellular and Molecular Medicine
Deficiency in the signal adaptor protein sequestosome 1 (SQSTM1/A170/p62) in mice is associated with mature-onset obesity, accompanied by insulin and leptin resistance. We previously established that redox sensitive transcription factor Nrf2 up-regul
Autor:
Hiroyuki Harada, Kazuhiro Nakaso, Toru Yanagawa, Hiroshi Yusa, Tetsuro Ishii, Yumi Koyama, Ken Omura, Satoshi Iwasa, Junya Uwayama, Hiroshi Yoshida, Kojiro Onizawa
Publikováno v:
International Journal of Oral and Maxillofacial Surgery. 34(8):915-920
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Peroxiredoxin (Prx) I is an antioxidant protein expressed in proliferating cells. We investigated Prx I as marker for tongue cancer status by correlating clinical features with Prx I expression. Samples from 132 patients with squ
Peroxiredoxin (Prx) I is an antioxidant protein expressed in proliferating cells. We investigated Prx I as marker for tongue cancer status by correlating clinical features with Prx I expression. Samples from 132 patients with squ
Autor:
Toru Yanagawa, Ken Itoh, Hiroshi Yoshida, Junya Uwayama, Tsuneyoshi Sano, Tetsuro Ishii, Masayuki Yamamoto, Yasuaki Shibata, Akira Yamaguchi
Publikováno v:
Genes to Cells. 9:641-651
Rodents have brownish-yellow incisors whose colour represents their iron content. Iron is deposited into the mature enamel by ameloblasts that outline enamel surface of the teeth. Nrf2 is a basic region-leucine zipper type transcription factor that r
Autor:
Keiko Yamastu, Toru Yanagawa, Hiroshi Yoshida, Eiji Warabi, Hirotoshi Utsunomiya, Tetsuro Ishii, Kosuke Okada, Junya Uwayama, Junichi Shoda, Koichi Takeda
Publikováno v:
Hepatology research : the official journal of the Japan Society of Hepatology. 39(5)
Aim Sequestosome 1 (SQSTM1)/A170/p62 plays an important role in membrane-receptor mediated signal transduction and autophagic protein degradation. Although the mechanism involved is not clear, sqstm1 gene knockout (KO) mice develop mature-onset obesi
Publikováno v:
Japanese Journal of Oral & Maxillofacial Surgery. 45:25-27
Autor:
Junya Uwayama, Aki Hirayama, Tetsuro Ishii, Ken Itoh, Akio Koyama, Eiji Warabi, Hiroshi Yoshida, Rika Sugimoto, Toru Yanagawa, Masayuki Yamamoto
Publikováno v:
Biochemical and biophysical research communications. 339(1)
Peroxiredoxin I (Prx I) is a key cytoplasmic peroxidase that reduces intracellular hydroperoxides in concert with thioredoxin. To study the role of tissue Prx I in protection from oxidative stress, we generated Prx I−/− mice by gene trapping. We
Autor:
Harumi Harada, Eiji Warabi, Taizo Matsuki, Toru Yanagawa, Kosuke Okada, Junya Uwayama, Akira Ikeda, Kazuhiro Nakaso, Kyoko Kirii, Noriko Noguchi, Hiroki Bukawa, Siow, Richard C. M., Mann, Giovanni E., Junichi Shoda, Ishii, Tetsuro, Takeshi Sakurai
Publikováno v:
Journal of Neuroscience; 9/11/2013, Vol. 33 Issue 37, p14767-14777, 11p
Autor:
Toru Yanagawa, Taichi Hara, Satoshi Waguri, Noboru Mizushima, Tohru Natsume, Eiki Kominami, Junya Uwayama, Yasuo Uchiyama, Eiji Warabi, Junji Ezaki, Takashi Ueno, Jun Hamazaki, Yu-shin Sou, Tetsuro Ishii, Keiji Tanaka, Masato Koike, Hiroshi Yoshida, Junichi Iwata, Yasumasa Nishito, Masaaki Komatsu, Shun-ichiro Iemura, Zhenyu Yue, Shigeo Murata, Masayuki Yamamoto, Akira Kobayashi
Publikováno v:
Cell. (6):1149-1163
SummaryInactivation of constitutive autophagy results in formation of cytoplasmic protein inclusions and leads to liver injury and neurodegeneration, but the details of abnormalities related to impaired autophagy are largely unknown. Here we used mou