Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Junya Unno"'
Autor:
Junya Unno, Akiko Itaya, Masato Taoka, Koichi Sato, Junya Tomida, Wataru Sakai, Kaoru Sugasawa, Masamichi Ishiai, Tsuyoshi Ikura, Toshiaki Isobe, Hitoshi Kurumizaka, Minoru Takata
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1039-1047 (2014)
The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand cr
Externí odkaz:
https://doaj.org/article/e36387d2c5d74315a6dd602ff2eac987
Autor:
Yuko Atsumi, Hiroaki Fujimori, Hirokazu Fukuda, Aki Inase, Keitaro Shinohe, Yoshiko Yoshioka, Mima Shikanai, Yosuke Ichijima, Junya Unno, Shuki Mizutani, Naoto Tsuchiya, Yoshitaka Hippo, Hitoshi Nakagama, Mitsuko Masutani, Hirobumi Teraoka, Ken-ichi Yoshioka
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23432 (2011)
Normal cells, both in vivo and in vitro, become quiescent after serial cell proliferation. During this process, cells can develop immortality with genomic instability, although the mechanisms by which this is regulated are unclear. Here, we show that
Externí odkaz:
https://doaj.org/article/6a82b0dd2df44ecebf661d5764d78eb9
Autor:
Yosuke Ichijima, Ken-ichi Yoshioka, Yoshiko Yoshioka, Keitaro Shinohe, Hiroaki Fujimori, Junya Unno, Masatoshi Takagi, Hidemasa Goto, Masaki Inagaki, Shuki Mizutani, Hirobumi Teraoka
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8821 (2010)
During tumorigenesis, cells acquire immortality in association with the development of genomic instability. However, it is still elusive how genomic instability spontaneously generates during the process of tumorigenesis. Here, we show that precancer
Externí odkaz:
https://doaj.org/article/1487fcda76eb4ba6b3ea1778ac53e194
Autor:
Toshiaki Isobe, Masamichi Ishiai, Masato Taoka, Koichi Sato, Akiko Itaya, Hitoshi Kurumizaka, Kaoru Sugasawa, Tsuyoshi Ikura, Minoru Takata, Junya Tomida, Junya Unno, Wataru Sakai
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1039-1047 (2014)
The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand cr
Autor:
Masamichi Ishiai, Minoru Takata, Tsuyoshi Ikura, Emi Uchida, Kenji Kamiya, Yuji Masuda, Tomonari Matsuda, Yoshihiko Maehara, Tomoko Shigechi, Junya Unno, Akira Matsuura, Akiko Itaya, Ken Ichi Yamamoto, Jun Adachi, Masahiko Kobayashi, Junya Tomida, Amom Ruhikanta Meetei, Masae Ikura, Shun Matsuda
Publikováno v:
Nucleic Acids Research
When DNA replication is stalled at sites of DNA damage, a cascade of responses is activated in the cell to halt cell cycle progression and promote DNA repair. A pathway initiated by the kinase Ataxia teleangiectasia and Rad3 related (ATR) and its par
Autor:
Mitsuko Masutani, Tomohiro Morio, Masataka Sugimoto, Jinhua Piao, Fumiko Honda, Fumiaki Watanabe, Daisuke Maeda, Shuki Mizutani, Junya Unno, Masatoshi Takagi, Hirobumi Teraoka, Tohru Kiyono
Publikováno v:
Cancer Sci
Stalled replication forks undergo DNA double-strand breaks (DSBs) under certain conditions. However, the precise mechanism underlying DSB induction and the cellular response to persistent replication fork stalling are not fully understood. Here we sh
Autor:
Hitoshi Nakagama, Aki Inase, Naoto Tsuchiya, Yuko Atsumi, Hirokazu Fukuda, Yoshiko Yoshioka, Junya Unno, Ken-ichi Yoshioka, Shuki Mizutani, Hirobumi Teraoka, Mima Shikanai, Keitaro Shinohe, Yosuke Ichijima, Mitsuko Masutani, Yoshitaka Hippo, Hiroaki Fujimori
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23432 (2011)
PLoS ONE
PLoS ONE
Normal cells, both in vivo and in vitro, become quiescent after serial cell proliferation. During this process, cells can develop immortality with genomic instability, although the mechanisms by which this is regulated are unclear. Here, we show that
Autor:
Yoshiko Yoshioka, Keitaro Shinohe, Ken-ichi Yoshioka, Junya Unno, Masatoshi Takagi, Hiroaki Fujimori, Shuki Mizutani, Yosuke Ichijima, Hidemasa Goto, Masaki Inagaki, Hirobumi Teraoka
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8821 (2010)
PLoS ONE
PLoS ONE
During tumorigenesis, cells acquire immortality in association with the development of genomic instability. However, it is still elusive how genomic instability spontaneously generates during the process of tumorigenesis. Here, we show that precancer
Autor:
M Ohta, Shuki Mizutani, Masayuki Nagasawa, Tomohiro Morio, Masanobu Kitagawa, Osamu Miura, Junya Unno, Masatoshi Takagi, Ayako Arai, S Horibe
Publikováno v:
Leukemia. 21(10)
Autor:
Hirobumi Teraoka, Daisuke Maeda, Tomohiro Morio, Junya Unno, Masatoshi Takagi, Mitsuko Masutani, Fumiko Honda, Shuki Mizutani, Thoru Kiyono
Publikováno v:
Blood. 114:1097-1097
Abstract 1097 Poster Board I-119 Hydroxyurea (HU) is an antineoplastic drug used in hematological malignancies, specifically polycythemia vera, essential thrombocytosis or chronic myelogenous leukemia. HU targets cells that are actively replicating D