Výsledky vyhledávání - "Junya Ohmori"

Autor: Shoko Tada, Junya Ohmori, Kyoichi Maeno, Mitsuyuki Matsumoto, Kazuyuki Hidaka, Tokio Yamaguchi

Publikováno v: NeuroReport. 7:2543-2546

We investigated some in vitro pharmacological properties of a novel human dopamine D2-like receptor antagonist, YM-50001 [(R)-5-chloro-4-cyclopropylacarbonylamino-2-methoxy-N-[1-(3-methox ybenzyl)- 3-pyrrolidinyl]benzamide monooxalate]. Receptor bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76b120cd2e7dd97e925ddcd0cd6f782
https://doi.org/10.1097/00001756-199611040-00028

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In vitro pharmacological profile of YM-43611, a novel D2-like receptor antagonist with high affinity and selectivity for dopamine D3 and D4 receptors

Autor: Yoshikazu Tasaki, Tokio Yamaguchi, Mitsuyuki Matsumoto, Shoko Tada, Junya Ohmori, Kazuyuki Hidaka, Tamako Nomura, Shinji Usuda

Publikováno v: British Journal of Pharmacology. 117:1625-1632

1. We investigated some neurochemical properties of a novel benzamide, YM-43611, [(S)-N-(1-benzyl-3-pyrrolidinyl)-5-chloro-4-cyclopropylcarbonylamino+ ++-2- methoxybenzamide] in comparison with putative D2-like receptor antagonists using both rat and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d48bd4be14af17a5222bd423e628ae3
https://doi.org/10.1111/j.1476-5381.1996.tb15332.x

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Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonists: Synthesis and Structure−Activity Relationships of 6-(1H-Imidazol-1-yl)- 7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and Related Compounds

Autor: Shuichi Sakamoto, Masao Shimizu-Sasamata, Junya Ohmori, Hirokazu Kubota, Masamichi Okada

Publikováno v: Journal of Medicinal Chemistry. 39:1331-1338

We have synthesized and evaluated azaquinoxalinediones 3a-c for their activity in inhibiting [3H]AMPA binding from rat whole brain. It was found that the azaquinoxalinedione nucleus functions as a bioisostere for quinoxalinedione in AMPA receptor bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75d40610d3aed8d42629d56ecd46870b
https://doi.org/10.1021/jm950304+

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Novel AMPA Receptor Antagonists: Synthesis and Structure−Activity Relationships of 1-Hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)- quinoxalinedione and Related Compounds

Autor: Masao Shimizu-Sasamata, Shuichi Sakamoto, Junya Ohmori, Masamichi Okada

Publikováno v: Journal of Medicinal Chemistry. 39:3971-3979

As part of our study of novel antagonists at the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) subtype of excitatory amino acid (EAA) receptors and the pharmacophoric requirements of the receptor, we designed and synthesized a series of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::380cbb2d721fa41a3c99458d6fa435b4
https://doi.org/10.1021/jm960387+

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6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor

Autor: Kiyoshi Murase, Toshio Furuya, Masao Shimizu-Sasamata, Junzi Togami, Junya Ohmori, Sachiko Kawasaki, Kazuyuki Hidaka, Shuichi Sakamoto, Hirokazu Kubota, Masamichi Okada

Publikováno v: Journal of Medicinal Chemistry. 37:467-475

A novel series of quinoxalinediones possessing imidazolyl and related heteroaromatic substituents was synthesized and evaluated for their activity to inhibit [ 3 H]AMPA binding from rat whole brain. From the structure-activity relationships, it was f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851e1674c7e353a223976e6b1f57e989
https://doi.org/10.1021/jm00030a006

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