Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Junya Azumi"'
Autor:
Tomoya Takeda, Junya Azumi, Mika Masaki, Takae Nagasawa, Yasuhiro Shimada, Hisashi Aso, Takashi Nakamura
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23296- (2024)
Red blood cells (RBCs) are renewed in a cyclic manner. Aging RBCs are captured and degraded by phagocytic cells, and heme metabolic pigments are subsequently excreted in feces. We evaluated the effect of an organogermanium compound on RBC metabolism
Externí odkaz:
https://doaj.org/article/cffe024dc56e43eeb9e16a4131fa0e1a
Autor:
Tomohiko Sakabe, Hiroyuki Tsuchiya, Keita Kanki, Junya Azumi, Kazue Gonda, Yusuke Mizuta, Daisaku Yamada, Hiroshi Wada, Kohei Shomori, Hiroaki Nagano, Goshi Shiota
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56197 (2013)
The incidence of advanced hepatocellular carcinoma (HCC) is increasing worldwide, and its prognosis is extremely poor. Interferon-alpha (IFN-α)/5-fluorouracil (5-FU) therapy is reportedly effective in some HCC patients. In the present study, to impr
Externí odkaz:
https://doaj.org/article/7fca056d4adf4ef89e7105ea1bb9e074
Autor:
Junya Azumi, Tomoya Takeda, Yasuhiro Shimada, Tao Zhuang, Yoshihiko Tokuji, Naoya Sakamoto, Hisashi Aso, Takashi Nakamura
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 1885
Volume 24
Issue 3
Pages: 1885
M1 macrophages are an important cell type related to tumor immunology and are known to phagocytose cancer cells. In previous studies, the organogermanium compound poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) and its hydrolysate, 3-(trihydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6bb3335e2faafd0c6c8aea1198a50e
https://doi.org/10.3390/ijms24031885
https://doi.org/10.3390/ijms24031885
Autor:
TOMOHIKO SAKABE1,2 saka0924@med.tottori-u.ac.jp, JUNYA AZUMI1, TOMOHIRO HARUKI3, YOSHIHISA UMEKITA2, HIROSHIGE NAKAMURA3, GOSHI SHIOTA1
Publikováno v:
Oncology Letters. May2017, Vol. 13 Issue 5, p3703-3708. 6p.
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4785 (2019)
Volume 20
Issue 19
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4785 (2019)
Volume 20
Issue 19
The organogermanium compound 3-(trihydroxygermyl)propanoic acid (THGP) has various biological activities. We previously reported that THGP forms a complex with cis-diol structures. L-3,4-Dihydroxyphenylalanine (L-DOPA), a precursor of melanin, contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffc2525be4d86c550686b964cd2b495
http://europepmc.org/articles/PMC6801725
http://europepmc.org/articles/PMC6801725
Autor:
Hiroaki Yamaguchi, Naoya Sakamoto, Hisashi Aso, Yasuhiro Shimada, Takashi Nakamura, Yoshihiko Tokuji, Junya Azumi, Sota Doiyama, Kosuke Nagata, Tomoya Takeda
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Reactive oxygen species (ROS) are very harmful to dermal cells, and it is thus important to develop cosmetics that protect the skin from ROS and other stimuli. Repagermanium is a synthetic water-soluble organogermanium polymer, and in this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c139820dac3a1281e3d257574256cb
http://europepmc.org/articles/PMC6754400
http://europepmc.org/articles/PMC6754400
Publikováno v:
Cancer Science
Sorafenib, a multi-kinase inhibitor, is the only standard clinical drug for patients with advanced hepatocellular carcinoma (HCC); however, development of sorafenib resistance in HCC often prevents its long-term efficacy. Therefore, novel targets and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35eee0f46de8771e397864cef3e1739
https://doi.org/10.1111/cas.13006
https://doi.org/10.1111/cas.13006
Autor:
Yasuaki Hirooka, Tomohiko Sakabe, Junya Azumi, Yoshihisa Umekita, Goshi Shiota, Kan Toriguchi, Etsuro Hatano
Publikováno v:
Liver International. 37:271-279
Background & Aims Cancer stem cells (CSCs) play a pivotal role in progression, metastasis, and recurrence of cancer. Therefore, it is clinically useful to identify the relevant CSC marker which is associated with prognosis of hepatocellular carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e189520937e049aa09e8798d30b2e85c
https://doi.org/10.1111/liv.13213
https://doi.org/10.1111/liv.13213
Autor:
Yohei Kono, Junya Azumi, Kan Toriguchi, Etsuro Hatano, Hiroki Shimizu, Kenji Oyama, Keita Kanki, Goshi Shiota
Publikováno v:
Gastrointestinal Tumors. 3:128-135
Background: Retinoids, vitamin A and its derivatives, have an antitumor effect on hepatocellular carcinoma (HCC). The function of retinoids is exerted by the complex of retinoic acid (RA) with the heterodimer of retinoid X receptor and the RA recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e9cbb5a72d1927e4f37384d5da635f
https://doi.org/10.1159/000448137
https://doi.org/10.1159/000448137
Autor:
Yo Mabuchi, Ken ichiro Abe, Toshihiko Sakurai, Tomohiko Sakabe, Hiroyuki Oka, Junya Azumi, Yoshiaki Matsumi, Noriko Itaba, Hiroyuki Saimoto, Yohei Kono, Goshi Shiota, Takayuki Tonoi, Yumi Matsuzaki, Minoru Morimoto, Keita Kanki, Hiroki Shimizu
Publikováno v:
Regenerative Therapy
Human mesenchymal stem cells (MSCs) are expected to have utility as a cell source in regenerative medicine. Because we previously reported that suppression of the Wnt/β-catenin signal enhances hepatic differentiation of human MSCs, we synthesized tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f73203c336f4fbde868fd36dcb6615