Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Junxian Geng"'
Publikováno v:
Journal of Innovative Optical Health Sciences, Vol 14, Iss 2, Pp 2150003-1-2150003-9 (2021)
Photodynamic therapy (PDT) has become an attractive tumor treatment modality because of its noninvasive feature and low side effects. However, extreme hypoxia inside solid tumors severely impedes PDT therapeutic outcome. To overcome this obstacle, va
Externí odkaz:
https://doaj.org/article/bfb866f1a04c450bac23867e4bb72e0c
Publikováno v:
Statistics in Biosciences. 14:413-431
Traditionally, dose-finding process for oncology compound is carried out in phase I dose escalation study and is driven by safety in order to find maximum tolerated dose (MTD). However, with the recent paradigm shift from cytotoxic drugs to new gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17666a27d902206d4058b28b97da714e
https://doi.org/10.1007/s12561-021-09327-1
https://doi.org/10.1007/s12561-021-09327-1
Publikováno v:
Bayesian Analysis; Jun2023, Vol. 18 Issue 2, p579-605, 27p
Autor:
Noboru Yamamoto, Anthony W. Tolcher, Navid Hafez, Iwona Lugowska, Rodryg Ramlau, Mrinal M. Gounder, Junxian Geng, Jian Li, Michael Teufel, Angela Maerten, Patricia LoRusso
Publikováno v:
Journal of Clinical Oncology. 41:543-543
543 Background: Standard-of-care treatment for advanced biliary tract cancer (BTC) is chemotherapy and outcomes remain poor; hence, there is a clinical need for effective targeted treatments. As MDM2 is a negative regulator of the tumor suppressor p5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f193cb2f42d6b76c200b32c743d77706
https://doi.org/10.1200/jco.2023.41.4_suppl.543
https://doi.org/10.1200/jco.2023.41.4_suppl.543
Publikováno v:
Statistics in Biosciences. 11:677-693
In designing dose-ranging studies at early Phase II, one of the major challenges is dose allocation or dose spacing. Binary dose spacing (BDS) has been established over the years as a practical and useful way of allocating doses. In this manuscript,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a17edcaef378d8e95f0ae04fe0b6878c
https://doi.org/10.1007/s12561-019-09261-3
https://doi.org/10.1007/s12561-019-09261-3
Autor:
Noboru Yamamoto, Navid Hafez, Anthony W. Tolcher, Michael Teufel, Junxian Geng, Liz Svensson, Mehdi Lahmar, Mrinal M. Gounder
Publikováno v:
Journal of Clinical Oncology. 40:3095-3095
3095 Background: Preclinical data show that combining a murine double minute 2–tumor protein 53 (MDM2–p53) antagonist with immune checkpoint inhibitors produces anti-tumor effects in multiple tumor types. This Phase Ia/Ib study (NCT03964233) is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::273f47695b07f514e0bf92ab5e69d278
https://doi.org/10.1200/jco.2022.40.16_suppl.3095
https://doi.org/10.1200/jco.2022.40.16_suppl.3095
Autor:
Mrinal M. Gounder, Noboru Yamamoto, Manish R. Patel, Todd Michael Bauer, Patrick Schöffski, Rolf Grempler, Sara Durland-Busbice, Junxian Geng, Angela Maerten, Patricia LoRusso
Publikováno v:
Journal of Clinical Oncology. 40:3004-3004
3004 Background: The highly potent MDM2–p53 antagonist BI 907828 showed antitumor efficacy in vivo, particularly in TP53 wild-type, MDM2-amplified de-differentiated LPS (DDLPS) patient-derived xenografts and syngeneic models. This phase I study (NC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e60aa9e0e08ddb7c7ca1d290d7b2adc5
https://doi.org/10.1200/jco.2022.40.16_suppl.3004
https://doi.org/10.1200/jco.2022.40.16_suppl.3004
Publikováno v:
2021 33rd Chinese Control and Decision Conference (CCDC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abcf80df3ff0b59d2371ff22792b7c74
https://doi.org/10.1109/ccdc52312.2021.9601586
https://doi.org/10.1109/ccdc52312.2021.9601586
Autor:
Mrinal M. Gounder, Patricia LoRusso, Scott A. Laurie, A. Perez-Pitarch, Junxian Geng, N. Yamamoto, M. Lahmar, Manish R. Patel, Todd M. Bauer, J. Cheng
Publikováno v:
Annals of Oncology. 32:S1124-S1125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e333b2c5f25bf814f32e1b3cb8a6568
https://doi.org/10.1016/j.annonc.2021.08.878
https://doi.org/10.1016/j.annonc.2021.08.878
Autor:
Elizabeth H. Slate, Junxian Geng
Publikováno v:
Statistical Modeling in Biomedical Research ISBN: 9783030334154
Biomarkers have great potential to improve disease diagnosis and treatment. Disease may arise via multiple pathways, however, each associated with distinct complex interactions among multiple biomarkers, and hence patients exhibit considerable hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::788340cb5baab7b0bce7a68365c9df91
https://doi.org/10.1007/978-3-030-33416-1_11
https://doi.org/10.1007/978-3-030-33416-1_11
