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Akademický článek

Specific in situ inflammatory states associate with progression to renal failure in lupus nephritis

Autor: Rebecca Abraham, Madeleine S. Durkee, Junting Ai, Margaret Veselits, Gabriel Casella, Yuta Asano, Anthony Chang, Kichul Ko, Charles Oshinsky, Emily Peninger, Maryellen L. Giger, Marcus R. Clark

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)

BACKGROUND In human lupus nephritis (LN), tubulointerstitial inflammation (TII) on biopsy predicts progression to end-stage renal disease (ESRD). However, only about half of patients with moderate-to-severe TII develop ESRD. We hypothesized that this

Externí odkaz: https://doaj.org/article/48c07970fe1844bdb97aea821879975f

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Akademický článek

In Situ Humoral Immunity to Vimentin in HLA-DRB1*03+ Patients With Pulmonary Sarcoidosis

Autor: Andrew J. Kinloch, Ylva Kaiser, Don Wolfgeher, Junting Ai, Anders Eklund, Marcus R. Clark, Johan Grunewald

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Vimentin has been implicated in pulmonary sarcoidosis as a T-cell autoantigen, particularly in the context of HLA-DRB1*03, the Vα2.3/Vβ22 T-cell receptor (TCR), and Löfgren’s syndrome. As vimentin is a known antigenic target in B-cell-mediated a

Externí odkaz: https://doaj.org/article/7c7944ffee0f4a508af87a99d7fd07f6

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Specific in situ inflammatory states associate with progression to renal failure in lupus nephritis

Publikováno v: The Journal of clinical investigation. 132(13)

BACKGROUNDIn human lupus nephritis (LN), tubulointerstitial inflammation (TII) on biopsy predicts progression to end-stage renal disease (ESRD). However, only about half of patients with moderate-to-severe TII develop ESRD. We hypothesized that this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbc31b12fd5f9e5c634195a455597f8
https://pubmed.ncbi.nlm.nih.gov/35775489

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In lupus nephritis, specificin situinflammatory states are associated with refractory disease and progression to renal failure

Autor: Margaret Veselits, Emily Peninger, Charles Oshinsky, Rebecca Abraham, Kichul Ko, Gabriel Casella, Madeleine S. Durkee, Yuta Asano, Marcus R. Clark, Maryellen L. Giger, Junting Ai, Anthony Chang

In human lupus nephritis (LN), tubulointerstitial inflammation (TII) on biopsy predicts progression to end stage renal disease (ESRD). However, while approximately half of patients with moderate or severe TII develop ESRD, half do not. Therefore, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30e7659d2f77af7906a31eca369a8f1f
https://doi.org/10.1101/2021.09.03.458909

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