Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Junsuke Igarashi"'
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 4, Pp 602-610 (2009)
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that exerts numerous biological activities both as a receptor ligand and as an intracellular second messenger. In the present study, we explored roles of sphingosine kinase (SphK), an S1P-p
Externí odkaz:
https://doaj.org/article/1a26e6a40e5f4a6ca431289d35a63119
Autor:
Takeshi Hashimoto, Junsuke Igarashi, Arif U Hasan, Koji Ohmori, Masakazu Kohno, Yukiko Nagai, Tetsuo Yamashita, Hiroaki Kosaka
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79724 (2013)
The steroid receptor antagonist mifepristone is used as an anti-cancer agent, eliciting both cytostatic and cytotoxic effects on malignant cells. However, the metabolic effects of long-term treatment with mifepristone have remained unclear. The effec
Externí odkaz:
https://doaj.org/article/eb6adc962faa411eb2dfd63ecb4c5b68
Autor:
Akira Nishiyama, Takeshi Hashimoto, Fuminori Yamaguchi, Masaaki Tokuda, Tetsuo Minamino, Tetsuo Yamashita, Arif Ul Hasan, Kazuyo Kamitori, Masakazu Kohno, Takahisa Noma, Kumi Konishi, Junsuke Igarashi, Koji Ohmori, Katsuya Hirano
Publikováno v:
Biogerontology. 18:55-68
Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794c516d7752dd6358837e507d7fb936
https://doi.org/10.1007/s10522-016-9661-9
https://doi.org/10.1007/s10522-016-9661-9
Autor:
Koichi Node, Toshiyuki Nishikido, Ikuko Tsukamoto, Jun-ichi Oyama, Aya Shiraki, Junsuke Igarashi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
2-Cl-C.OXT-A (COA-Cl) is a novel nucleic acid analogue that promotes tube-forming activity of human umbilical vein endothelial cells (HUVEC) through vascular endothelial growth factor (VEGF). The development of coronary collateral circulation is crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6fd00e12714a5be739fee171777263
https://pubmed.ncbi.nlm.nih.gov/30796271
https://pubmed.ncbi.nlm.nih.gov/30796271
Autor:
Masaaki Tokuda, Kazuyo Kamitori, Takahisa Noma, Junsuke Igarashi, Fuminori Yamaguchi, Kumi Konishi, Ikuko Tsukamoto, Yasuhiro Ishihara, Arif Ul Hasan, Toru Uyama, Masakazu Kohno, Koji Ohmori, Takeshi Hashimoto
Publikováno v:
Molecular and Cellular Endocrinology. 406:10-18
Vascular endothelial growth factor-A (VEGF-A) released from adipocytes promotes angiogenesis; and thereby ameliorates the local hypoxia-induced adipose inflammation and insulin resistance. Here, we newly found that eicosapentaenoic acid (EPA) upregul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bbf35a2351b689674d56cd131e4f89
https://doi.org/10.1016/j.mce.2015.02.012
https://doi.org/10.1016/j.mce.2015.02.012
Autor:
Norikazu Sakakibara, Yoshihisa Kato, Junsuke Igarashi, Ryoji Konishi, Maki Takata, Ikuko Tsukamoto
Publikováno v:
Chemicalpharmaceutical bulletin. 65(5)
Five novel nucleoside analogs with mono or bis-hydroxymethylated cyclopropane rings at the N9-position of the 2-chloroadenine moiety (2-chloro-carbocyclic oxetanocin A [COA-Cl] analog) were synthesized and evaluated using human umbilical vein endothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fcd71eda1eafa6b664ec79e745c295
https://pubmed.ncbi.nlm.nih.gov/28458372
https://pubmed.ncbi.nlm.nih.gov/28458372
Autor:
Masaaki Tokuda, Kazuhito Tsuboi, Kazuyo Kamitori, Fuminori Yamaguchi, Arif Ul Hasan, Junsuke Igarashi, Koji Ohmori, Akira Nishiyama, Takeshi Hashimoto, Masakazu Kohno, Takahisa Noma
Publikováno v:
Biochemical and biophysical research communications. 486(1)
How nutritional excess leads to inflammatory responses in metabolic syndrome is not well characterized. Here, we evaluated the effects of ω-3 polyunsaturated fatty acid specific G-protein coupled receptor 120 (GPR120) activation on inflammatory path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12933c30c47607d82db1d81a5dd075d0
https://pubmed.ncbi.nlm.nih.gov/28263744
https://pubmed.ncbi.nlm.nih.gov/28263744
Autor:
Ikuko Tsukamoto, Junsuke Igarashi, Kazuyo Shoji, Hiroaki Kosaka, Kozo Yoneda, Tetsuya Moriue, Takeshi Hashimoto, Yasuo Kubota
Publikováno v:
American Journal of Physiology-Cell Physiology. 304:C790-C800
Steroids exert direct actions on cardiovascular cells, although underlying molecular mechanisms remain incompletely understood. We examined if steroids modulate abundance of caveolin-1, a regulatory protein of cell-surface receptor pathways that regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f44f1be82a9bcb164b76c8da6a7ce7
https://doi.org/10.1152/ajpcell.00268.2012
https://doi.org/10.1152/ajpcell.00268.2012
Autor:
Tetsuo Yamashita, Hiroaki Kosaka, Yu Yang, Nozomu Mori, Eiko Nakamaru-Ogiso, Hideto Miyoshi, Takeshi Hashimoto, Akemi Matsuno-Yagi, Takao Yagi, Junsuke Igarashi, Masatoshi Murai
Publikováno v:
Journal of Biological Chemistry. 286:9287-9297
The flavoprotein rotenone-insensitive internal NADH-ubiquinone (UQ) oxidoreductase (Ndi1) is a member of the respiratory chain in Saccharomyces cerevisiae. We reported previously that bound UQ in Ndi1 plays a key role in preventing the generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36349c6f73793c03b4ab4f98f827b00b
https://doi.org/10.1074/jbc.m110.175547
https://doi.org/10.1074/jbc.m110.175547
Autor:
Kozo Nakai, Koji Ohmori, Masakazu Kohno, Junsuke Igarashi, Tetsuya Moriue, Yasuo Kubota, Yasuhiro Ishihara, Hiroaki Kosaka, Kozo Yoneda
Publikováno v:
Experimental Dermatology. 20:388-393
Obesity is known to be associated with a number of effects on skin physiology. KKA(y) obese mouse is a model of type 2 diabetes characterized by systemic oxidative stress because of severe obesity, hypertriglyceridaemia, hyperglycaemia and hyperinsul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca73b5c0399b6ffe51b2611a8cddeaee
https://doi.org/10.1111/j.1600-0625.2010.01223.x
https://doi.org/10.1111/j.1600-0625.2010.01223.x