Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Junping Pei"'
Autor:
Kunyu Shi, Guan Wang, Junping Pei, Jifa Zhang, Jiaxing Wang, Liang Ouyang, Yuxi Wang, Weimin Li
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-44 (2022)
Abstract Epidermal growth factor receptor (EGFR), the receptor for members of the epidermal growth factor family, regulates cell proliferation and signal transduction; moreover, EGFR is related to the inhibition of tumor cell proliferation, angiogene
Externí odkaz:
https://doaj.org/article/d543fc0fd3784947b4ac85e812f85d67
Autor:
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 5, Pp 2171-2192 (2022)
The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway is widely activated by a variety of extracellular stimuli, and its dysregulation is associated with the proliferation, invasion, and migr
Externí odkaz:
https://doaj.org/article/5a16c7774aa948b091111df55bd118b6
Publikováno v:
Green Synthesis and Catalysis, Vol 3, Iss 1, Pp 11-24 (2022)
With the improvements in computer computing ability, data accumulation and rapid algorithm development, the integration of artificial intelligence (AI) and drug synthesis has been accelerated, significantly improving the design and synthesis of drug
Externí odkaz:
https://doaj.org/article/b84f48a330134d02b66505156470f43a
Autor:
Kai Zhang, Shiou Zhu, Jiamei Li, Tingting Jiang, Lu Feng, Junping Pei, Guan Wang, Liang Ouyang, Bo Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Parkinson's disease (PD), known as one of the most universal neurodegenerative diseases, is a serious threat to the health of the elderly. The current treatment has been demonstrated to relieve symptoms, and the discovery of new small-molecule compou
Externí odkaz:
https://doaj.org/article/2f99c69d80204691acdb51aafb492f32
Autor:
Junping Pei, Guan Wang, Aoxue Wang, Chengyong Wu, Xiaoli Pan, Wen Shuai, Faqian Bu, Yumeng Zhu, Yuxi Wang, Liang Ouyang, Weimin Li
Publikováno v:
Journal of Medicinal Chemistry. 66:5719-5752
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::668f76820e833d92d017f74000fa4fb4
https://doi.org/10.1021/acs.jmedchem.3c00027
https://doi.org/10.1021/acs.jmedchem.3c00027
Autor:
Yumeng Zhu, Wen Shuai, Min Zhao, Xiaoli Pan, Junping Pei, Yongya Wu, Faqian Bu, Aoxue Wang, Liang Ouyang, Guan Wang
Publikováno v:
Journal of Medicinal Chemistry. 65:3758-3775
c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, are encoded by three genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c758ab14d4dd4697e284ad2c79ab1d3
https://doi.org/10.1021/acs.jmedchem.1c01947
https://doi.org/10.1021/acs.jmedchem.1c01947
Publikováno v:
Green Synthesis and Catalysis. 3:11-24
With the improvements in computer computing ability, data accumulation and rapid algorithm development, the integration of artificial intelligence (AI) and drug synthesis has been accelerated, significantly improving the design and synthesis of drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7ee413541404db213f014d7fa57eacd
https://doi.org/10.1016/j.gresc.2021.11.007
https://doi.org/10.1016/j.gresc.2021.11.007
Autor:
Junping Pei, Wen Shuai, Guan Wang, Aoxue Wang, Feng Lin, Liang Ouyang, Lu Feng, Yuxi Wang, Congcong Lin
Publikováno v:
Journal of Medicinal Chemistry. 64:16328-16348
Activated Cdc42-associated kinase 1 (ACK1/TNK2) is a nonreceptor tyrosine kinase with a unique structure. It not only can act as an activated transmembrane effector of receptor tyrosine kinases (RTKs) to transmit various RTK signals but also can play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32933d2717941b8c582a2c08c24cf9e7
https://doi.org/10.1021/acs.jmedchem.1c01030
https://doi.org/10.1021/acs.jmedchem.1c01030
Autor:
Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Parkinson's disease (PD), known as one of the most universal neurodegenerative diseases, is a serious threat to the health of the elderly. The current treatment has been demonstrated to relieve symptoms, and the discovery of new small-molecule compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dab43aca56bfd6a912c2aa71297ff
http://www.sciencedirect.com/science/article/pii/S2211383521000642
http://www.sciencedirect.com/science/article/pii/S2211383521000642
Publikováno v:
Journal of Medicinal Chemistry. 64:3493-3507
A series of tools for targeted protein degradation are inspiring scientists to develop new drugs with advantages over traditional small-molecule drugs. Among these tools, proteolysis-targeting chimeras (PROTACs) are most representative of the technol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e26652709d6ef040577f5a676713636
https://doi.org/10.1021/acs.jmedchem.0c01689
https://doi.org/10.1021/acs.jmedchem.0c01689