Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Juno M. Krahn"'
Autor:
Jacob Gordon, Fleur L. Chapus, Elizabeth G. Viverette, Jason G. Williams, Leesa J. Deterding, Juno M. Krahn, Mario J. Borgnia, Joseph Rodriguez, Alan J. Warren, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
PELP1 is a large scaffolding protein implicated in many cellular activities, including ribosome assembly as part of the Rix1 complex, comprising PELP1, WDR18, TEX10 and other components. Here, authors present the cryo-EM structure of PELP1 in complex
Externí odkaz:
https://doaj.org/article/7a28ba5ed69749b48501c3dc0b091105
Autor:
Thomas W. Kirby, Scott A. Gabel, Eugene F. DeRose, Lalith Perera, Juno M. Krahn, Lars C. Pedersen, Robert E. London
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1603 (2023)
Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an asymmetric p66/p66′ homodimer. These studies were undertaken to evaluate whether the inform
Externí odkaz:
https://doaj.org/article/376b12fa42bb4eceacdfd0459bcc8b10
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract Background Human cancer cell line profiling and drug sensitivity studies provide valuable information about the therapeutic potential of drugs and their possible mechanisms of action. The goal of those studies is to translate the findings fr
Externí odkaz:
https://doaj.org/article/4b1de6683af848de92c5bf39c5ce389f
Autor:
Monica C. Pillon, Meredith N. Frazier, Lucas B. Dillard, Jason G. Williams, Seda Kocaman, Juno M. Krahn, Lalith Perera, Cassandra K. Hayne, Jacob Gordon, Zachary D. Stewart, Mack Sobhany, Leesa J. Deterding, Allen L. Hsu, Venkata P. Dandey, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nsp15 is a uridine specific endoribonuclease present in all coronaviruses. Here, the authors determine the cryo-EM structures of SARS-CoV-2 Nsp15 in the apo and UTP-bound states, which together with biochemical experiments, mass spectrometry and mole
Externí odkaz:
https://doaj.org/article/3b3bd68422cc4508a02721056de1a082
Autor:
Yu-Hua Lo, Mack Sobhany, Allen L. Hsu, Brittany L. Ford, Juno M. Krahn, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Rix7 is a type II AAA-ATPase that is required for the assembly of the large ribosomal subunit. Here the authors present the 4.5 Å cryo-EM structure of the Rix7 homohexamer with a polypeptide fragment bound in its central channel and provide insight
Externí odkaz:
https://doaj.org/article/532b14f2bbab448784ac75464a65da1f
Autor:
Joonas A. Jamsen, William A. Beard, Lars C. Pedersen, David D. Shock, Andrea F. Moon, Juno M. Krahn, Katarzyna Bebenek, Thomas A. Kunkel, Samuel H. Wilson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
DNA polymerase (pol) μ functions in DNA double-strand break repair. Here the authors use time-lapse X-ray crystallography to capture the states of pol µ during the conversion from pre-catalytic to product complex and observe a third transiently bou
Externí odkaz:
https://doaj.org/article/982a48bce8204f249e81938b26845c43
A comprehensive genomic pan-cancer classification using The Cancer Genome Atlas gene expression data
Autor:
Yuanyuan Li, Kai Kang, Juno M. Krahn, Nicole Croutwater, Kevin Lee, David M. Umbach, Leping Li
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract Background The Cancer Genome Atlas (TCGA) has generated comprehensive molecular profiles. We aim to identify a set of genes whose expression patterns can distinguish diverse tumor types. Those features may serve as biomarkers for tumor diagn
Externí odkaz:
https://doaj.org/article/73c69f5aaf2b419faf7154fd6d1767bf
Autor:
Amanda A. Riccio, Jonathan Bouvette, Matthew J. Longley, Juno M. Krahn, Mario J. Borgnia, William C. Copeland
Publikováno v:
Methods. 205:263-270
The mitochondrial replisome replicates the 16.6 kb mitochondria DNA (mtDNA). The proper functioning of this multicomponent protein complex is vital for the integrity of the mitochondrial genome. One of the critical protein components of the mitochond
Autor:
Bradley P, Klemm, Deepa, Singh, Cassandra E, Smith, Allen L, Hsu, Lucas B, Dillard, Juno M, Krahn, Robert E, London, Geoffrey A, Mueller, Mario J, Borgnia, Roel M, Schaaper
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(37)
Levels of the cellular dNTPs, the direct precursors for DNA synthesis, are important for DNA replication fidelity, cell cycle control, and resistance against viruses.
Autor:
Eduardo Stancanelli, Vijayakanth Pagadala, Truong Quang Pham, Juno M. Krahn, Andrea M. Kaminski, Rylee Wander, Yongmei Xu, Lars C. Pedersen, Jian Liu, Zhangjie Wang, Jine Li
Publikováno v:
ACS Catal
Heparan sulfate 3-O-sulfotransferase (3-OST) transfers a sulfo group to the 3-OH position of a glucosamine saccharide unit to form 3-O-sulfated heparan sulfate. 3-O-sulfation is known to be critically important for bestowing anticoagulant activity an