Výsledky vyhledávání

The Mouse/Human Chimeric Monoclonal Antibody cA2 Neutralizes TNF In Vitro and Protects Transgenic Mice from Cachexia and TNF Lethality In Vivo

Autor: Junming Le, George Kollias, David J. Shealy, Lesley Probert, Jan Vilcek, Peter E. Daddona, Marian T. Nakada, Donna S. Woulfe, John Ghrayeb, Scott A. Siegel

Publikováno v: Cytokine. 7:15-25

The pleiotropic cytokine tumour necrosis factor-alpha (TNF) is thought to play a central role in infectious, inflammatory and autoimmune diseases. Critical to the understanding and management of TNF-associated pathology is the development of highly s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82dcbacab68f1896b6b4aa9ab5c41ad
https://doi.org/10.1006/cyto.1995.1003

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Targeted amplification of alternatively spliced transcripts of major histocompatibility complex class I heavy chain

Autor: Deping Yang, Junming Le

Publikováno v: Journal of Immunological Methods. 176:265-270

The RPMI1788 cell line was found to produce soluble form of HLA class I molecules (sHLA) constitutively, due at least in part to an alternative splicing mechanism in which exon 5 of HLA class I heavy chain transcripts is deleted. Reverse transcriptio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0d4b0701b05ecec397571a650b03e3
https://doi.org/10.1016/0022-1759(94)90320-4

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Construction and initial characterization of a mouse-human chimeric anti-TNF antibody

Autor: David M. Knight, Han Trinh, Junming Le, Scott Siegel, David Shealy, Margaret McDonough, Bernard Scallon, Maria Arevalo Moore, Jan Vilcek, Peter Daddona, John Ghrayeb

Publikováno v: Molecular Immunology. 30:1443-1453

Tumor necrosis factor-alpha (TNF) has been implicated in the pathogenesis of a variety of human diseases including septic shock, cachexia, graft-versus-host disease and several autoimmune diseases. Monoclonal antibodies directed against TNF provide a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200d0868c41649b83c93dba9eabdc55c
https://doi.org/10.1016/0161-5890(93)90106-l

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Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide

Autor: Jan Vilcek, Junming Le, Michel Aguet, Ryutaro Kamijo, Sui Huang, Edward A. Havell, Maarten C. Bosland, Deborah Shapiro

Publikováno v: The Journal of Experimental Medicine

Mice with a targeted disruption of the interferon gamma receptor gene (IFN-gamma R0/0 mice) and control wild-type mice were inoculated with the Bacillus Calmette-Guérin (BCG) strain of Mycobacterium bovis. BCG infection was not lethal for wild-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15177b07b8eeac56774bb5e705f1eff9
http://europepmc.org/articles/PMC2191201

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Up-regulation of cyclooxygenase-2 expression by TSG-6 protein in macrophage cell line

Autor: Catalin Mindrescu, Junming Le, Hans-Georg Wisniewski, Jan Vilcek

Publikováno v: Biochemical and biophysical research communications. 330(3)

TNF-stimulated gene 6 (TSG-6) encodes a 35 kDa inducible secreted glycoprotein important in inflammation and female fertility. Previous studies have shown that TSG-6 has anti-inflammatory activity in models of acute and chronic inflammation. In the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937be0a48db6c9407994c16920120bb9
https://pubmed.ncbi.nlm.nih.gov/15809059

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Alternative splicing of HLA class I transcripts induced by IFN-gamma and TNF in fibroblasts: release of soluble HLA class I heavy chain and an associate protein

Autor: Junming Le, Xiao He

Publikováno v: Cellular immunology. 162(1)

FS-4 fibroblasts were found to produce 37-kDa HLA class I heavy chain in response to IFN-gamma or TNF in a time- and dose-dependent fashion, and a synergism between IFN-gamma and TNF was observed. Immunoprecipitation of IFN-gamma- or TNF-induced FS-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891829f6547e712d63b4ef61a7ef6d3e
https://pubmed.ncbi.nlm.nih.gov/7704905

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Production of soluble HLA-class-I molecules by IFN-gamma-induced colon-adenocarcinoma cells

Autor: Junming Le, Jia-Cheng Hua

Publikováno v: International journal of cancer. 60(4)

High levels of soluble HLA-class-I molecules (sHLA) were found to be produced in a time- and dose-dependent manner by colon-adenocarcinoma Colo205 cells in response to IFN-gamma stimulation. Among other cytokines tested, only IL-6, TNF, IFN-alpha and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb68d7a9ba05ff63c25318b4ed9c108
https://pubmed.ncbi.nlm.nih.gov/7829274

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Requirement for transcription factor IRF-1 in NO synthase induction in macrophages

Autor: Tohru Kimura, J. Gerecitano, S. I. Koh, Jan Vilcek, Tadatsugu Taniguchi, Junming Le, Toshifumi Matsuyama, T. W. Mak, Shawn J. Green, Maarten C. Bosland, Deborah Shapiro, Hisashi Harada, Ryutaro Kamijo

Publikováno v: Science (New York, N.Y.). 263(5153)

Production of nitric oxide (NO) by macrophages is important for the killing of intracellular infectious agents. Interferon (IFN)-gamma and lipopolysaccharide stimulate NO production by transcriptionally up-regulating the inducible NO synthase (iNOS).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33f3aab65f3eae4c065f258b3374bd7
https://pubmed.ncbi.nlm.nih.gov/7510419

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