Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Junming, Yie"'
Autor:
Xiaoshan Min, Junming Yie, Jinghong Wang, Ben C. Chung, Ching-Shin Huang, Haoda Xu, Jie Yang, Liying Deng, Joanne Lin, Qing Chen, Christina M. Abbott, Caroline Gundel, Stephen A. Thibault, Tina Meng, Darren L. Bates, David J. Lloyd, Murielle M. Véniant, Zhulun Wang
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases. Pharmacological i
Externí odkaz:
https://doaj.org/article/968f0a3d32354e02bad2c843bdc326da
Autor:
Ching-Shin Huang, Caroline Gundel, Ben C. Chung, Joanne Lin, Qing Chen, Liying Deng, Darren L. Bates, Zhulun Wang, Jinghong Wang, Jie Yang, Murielle M. Véniant, David Lloyd, Xiaoshan Min, Stephen A. Thibault, Haoda Xu, Christina Abbott, Tina Meng, Junming Yie
Publikováno v:
mAbs
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases. Pharmacological i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ec036e73660230e011396dc0673377
https://doi.org/10.1080/19420862.2019.1710047
https://doi.org/10.1080/19420862.2019.1710047
Autor:
Randy Hecht, Yue-Sheng Li, Jeonghoon Sun, Ed Belouski, Michael Hall, Todd Hager, Junming Yie, Wei Wang, Dwight Winters, Stephen Smith, Chris Spahr, Lei-Ting Tam, Zhongnan Shen, Shanaka Stanislaus, Narumol Chinookoswong, Yvonne Lau, Allen Sickmier, Mark Leo Michaels, Thomas Boone, Murielle M Véniant, Jing Xu
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49345 (2012)
Fibroblast growth factor 21 (FGF21) is a promising drug candidate for the treatment of type 2 diabetes. However, the use of wild type native FGF21 is challenging due to several limitations. Among these are its short half-life, its susceptibility to i
Externí odkaz:
https://doaj.org/article/4b03784bd0594b29a2d0316fd49362ba
Autor:
Kalyani Mondal, Geoffrey Horner, Manuel E. Lopez, Mark J. Solloway, Chen M, Laird T, Gao Z, Raj Haldankar, Andre White, Yao J, Wang M, Tang J, Avantika Kekatpure, Hugo Matern, Bernard B. Allan, Chan J, Alice Chen Y, Dina A. Ayupova, Higbee Jared Martin, Damodharan Lakshminarasimhan, Li B, Tian H, To C, Hsu Jy, Alan Kutach, Tom Parsons, Wang Sp, Shen Wd, Suzanne Christine Crawley, Joo W, Junming Yie, Darrin A. Lindhout, cEntee M, Fu D
Publikováno v:
Nature. 550:255-259
Under homeostatic conditions, animals use well-defined hypothalamic neural circuits to help maintain stable body weight, by integrating metabolic and hormonal signals from the periphery to balance food consumption and energy expenditure. In stressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a4a24186b546405f4cc938c49643d3
https://doi.org/10.1038/nature24042
https://doi.org/10.1038/nature24042
Autor:
Dwight Winters, Todd Hager, Michael Hall, Shanaka Stanislaus, Murielle M. Véniant, Randy Ira Hecht, Chris Spahr, Lei Zhou, Jing Xu, Wei Wang, Yang Li, Junming Yie, Yue-Sheng Li, Liying Deng, Jennifer Weiszmann, Stephen Smith
Publikováno v:
Endocrinology. 158:1314-1327
Fibroblast growth factor (FGF) 21 is a natural hormone that modulates glucose, lipid, and energy metabolism. Previously, we engineered an Fc fusion FGF21 variant with two mutations, Fc-FGF21(RG), to extend the half-life and reduce aggregation and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e301d1ddf343756228eca215f2028d
https://doi.org/10.1210/en.2016-1917
https://doi.org/10.1210/en.2016-1917
Autor:
Brandon C. P. Clavette, Xiaoshan Min, Joanne Lin, Elizabeth A. Killion, Robert J.M. Kurzeja, David Lloyd, Liying Deng, Zhulun Wang, Clarence Hale, Christopher Murawsky, Stone D.-H. Shi, Murielle M. Véniant, Jinghong Wang, James B. Rottman, Christina Abbott, Todd Hager, Lu Shu Chen, Junming Yie, Ian Foltz, Qing Chen, Stephen A. Thibault, Darren L. Bates, Renee Komorowski, Larissa Atangan, Glenn Sivits, Tina Meng
Publikováno v:
Science Translational Medicine. 10
Glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) has been identified in multiple genome-wide association studies (GWAS) as a contributor to obesity, and GIPR knockout mice are protected against diet-induced obesity (DIO). On the bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4219a5cd6927493203264b2541e2f88b
https://doi.org/10.1126/scitranslmed.aat3392
https://doi.org/10.1126/scitranslmed.aat3392
Autor:
Ying Zhang, Sandhya Kashi, Junming Yie, Monisha Dey, Thuan Hong Le, Joseph Sergi, Kevin B. Gurney, Jianying Su
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 186:113328
A rabbit blood sugar bioidentity assay is required by the FDA to evaluate biological activity for all insulin and its analogs per USP121guideline. Not only are a large number of live animals used, but the rabbit blood sugar method is also highly vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc77dfe3462a28341b72371dc9fc2fb
https://doi.org/10.1016/j.jpba.2020.113328
https://doi.org/10.1016/j.jpba.2020.113328
Autor:
Jer-Yuan Hsu, Suzanne Crawley, Michael Chen, Dina A. Ayupova, Darrin A. Lindhout, Jared Higbee, Alan Kutach, William Joo, Zhengyu Gao, Diana Fu, Carmen To, Kalyani Mondal, Betty Li, Avantika Kekatpure, Marilyn Wang, Teresa Laird, Geoffrey Horner, Jackie Chan, Michele McEntee, Manuel Lopez, Damodharan Lakshminarasimhan, Andre White, Sheng-Ping Wang, Jun Yao, Junming Yie, Hugo Matern, Mark Solloway, Raj Haldankar, Thomas Parsons, Jie Tang, Wenyan D. Shen, Yu Alice Chen, Hui Tian, Bernard B. Allan
Publikováno v:
Nature. 551(7680)
This corrects the article DOI: 10.1038/nature24042.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb31fdd89d2957a15ffb2146efb0c67
https://pubmed.ncbi.nlm.nih.gov/28953886
https://pubmed.ncbi.nlm.nih.gov/28953886
Autor:
Tao Wu, Junming Yie
Publikováno v:
Biosimilars of Monoclonal Antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c416eb316d038facda60d10dfa9ef6ea
https://doi.org/10.1002/9781118940648.ch10
https://doi.org/10.1002/9781118940648.ch10
Autor:
Amy N. Duguay, Yang Li, Richard Smith, Ed Belouski, Junming Yie, Shanaka Stanislaus, Jing Xu, Ling Cai, Xinle Wu, Jamila Gupte, Jennifer Weiszmann
Publikováno v:
BioDrugs. 27:159-166
Fibroblast growth factor 21 (FGF21) has potent effects on normalizing glucose, lipid, and energy homeostasis, and represents an attractive novel therapy for type 2 diabetes mellitus and obesity. Approaches to improve the pharmacokinetic properties of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b76ecc4dbc778f6fce90fcae3dce4a0
https://doi.org/10.1007/s40259-013-0013-x
https://doi.org/10.1007/s40259-013-0013-x