Zobrazeno 1 - 10
of 445
pro vyhledávání: '"Junmin Peng"'
Autor:
Xingjian Li, Hanwen Zhu, Bik Tzu Huang, Xianting Li, Heesoo Kim, Haiyan Tan, Yuanxi Zhang, Insup Choi, Junmin Peng, Pingyi Xu, Ji Sun, Zhenyu Yue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of RAB GTPases, and their phosphorylation levels are elevated by Parkinson’s disease (PD)-linked mutations of LRRK2. However, the precise function of the LRRK2-regulated RAB
Externí odkaz:
https://doaj.org/article/c6642f6ccf0b48588573ea27ac7e5236
Autor:
Bitna Lim, Yurika Matsui, Seunghyun Jung, Mohamed Nadhir Djekidel, Wenjie Qi, Zuo-Fei Yuan, Xusheng Wang, Xiaoyang Yang, Nina Connolly, Abbas Shirinifard Pilehroud, Haitao Pan, Fang Wang, Shondra M Pruett-Miller, Kanisha Kavdia, Vishwajeeth Pagala, Yiping Fan, Junmin Peng, Beisi Xu, Jamy C Peng
Publikováno v:
PLoS Biology, Vol 22, Iss 9, p e3002760 (2024)
53BP1 is a well-established DNA damage repair factor that has recently emerged to critically regulate gene expression for tumor suppression and neural development. However, its precise function and regulatory mechanisms remain unclear. Here, we showe
Externí odkaz:
https://doaj.org/article/3af8bfdefb644757874ab04b0b84994b
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Deconvolution is an efficient approach for detecting cell-type-specific (cs) transcriptomic signals without cellular segmentation. However, this type of methods may require a reference profile from the same molecular source and tissue type.
Externí odkaz:
https://doaj.org/article/dc02b5c30fe0466fbb9c9e8a3fad1795
Autor:
Xiaoting Zhou, You-Kyung Lee, Xianting Li, Henry Kim, Carlos Sanchez-Priego, Xian Han, Haiyan Tan, Suiping Zhou, Yingxue Fu, Kerry Purtell, Qian Wang, Gay R. Holstein, Beisha Tang, Junmin Peng, Nan Yang, Zhenyu Yue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis. Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative diseases. However, the exact role and targets of autophagy in human n
Externí odkaz:
https://doaj.org/article/71903ec458994596b1e2fc44fc246235
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Meningioma, the most prevalent intracranial tumor, possesses a significant propensity for malignant transformation. Circular RNAs (circ-RNAs), a class of non-coding RNAs, have emerged as crucial players in tumorigenesis. This stud
Externí odkaz:
https://doaj.org/article/3c4ee4f26d0a42b4923f50bcb6eed796
Autor:
Ming Shao, Qingfei Pan, Haiyan Tan, Jing Wu, Ha Won Lee, Andrew D. Huber, William C. Wright, Ji-Hoon Cho, Jiyang Yu, Junmin Peng, Taosheng Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 4, Pp 101079- (2024)
CYP3A5 is a cytochrome P450 (CYP) enzyme that metabolizes drugs and contributes to drug resistance in cancer. However, it remains unclear whether CYP3A5 directly influences cancer progression. In this report, we demonstrate that CYP3A5 regulates gluc
Externí odkaz:
https://doaj.org/article/9ad3267c458a4173bd3a65ec2f9de8f9
Publikováno v:
IEEE Access, Vol 12, Pp 140253-140261 (2024)
This paper investigates the output synchronization problem for multiple parametric strict feedback (PSF) systems with unknown control directions. Prescribed performance control is employed to simultaneously ensure both transient and steady-state prop
Externí odkaz:
https://doaj.org/article/ed31b1c2900a4e38b0ce1d6fd6634aa8
Autor:
Gisele Nishiguchi, Lauren G. Mascibroda, Sarah M. Young, Elizabeth A. Caine, Sherif Abdelhamed, Jeffrey J. Kooijman, Darcie J. Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M. Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, Allister J. Loughran, Ravi Kalathur, Kaiwen Yu, Suiping Zhou, Xusheng Wang, Anthony A. High, Junmin Peng, Shondra M. Pruett-Miller, Danette L. Daniels, Marjeta Urh, Anang A. Shelat, Charles G. Mullighan, Kristin M. Riching, Guido J. R. Zaman, Marcus Fischer, Jeffery M. Klco, Zoran Rankovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Molecular-glue degraders are small molecules that induce a specific interaction between an E3 ligase and a target protein, resulting in the target proteolysis. The discovery of molecular glue degraders currently relies mostly on screening ap
Externí odkaz:
https://doaj.org/article/93a742dfa7284effac1e877a18d0d84e
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Precision medicine, characterized by the personalized integration of a patient’s genetic blueprint and clinical history, represents a dynamic paradigm in healthcare evolution. The emerging field of personalized anesthesia is at the intersection of
Externí odkaz:
https://doaj.org/article/53ef75cfd1794a84a6f8d366b4e9adfd
Autor:
Carolyn M Jablonowski, Waise Quarni, Shivendra Singh, Haiyan Tan, Dhanushka Hewa Bostanthirige, Hongjian Jin, Jie Fang, Ti-Cheng Chang, David Finkelstein, Ji-Hoon Cho, Dongli Hu, Vishwajeeth Pagala, Sadie Miki Sakurada, Shondra M Pruett-Miller, Ruoning Wang, Andrew Murphy, Kevin Freeman, Junmin Peng, Andrew M Davidoff, Gang Wu, Jun Yang
Publikováno v:
eLife, Vol 12 (2024)
Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how p
Externí odkaz:
https://doaj.org/article/56c3296c6a1943a796dba4f0a49cdf21