Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Junmei Ye"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The cGAS-STING signaling pathway plays a critical role in innate immunity and defense against viral infections by orchestrating intracellular and adaptive immune responses to DNA. In the context of head and neck squamous cell carcinoma (HNSCC), this
Externí odkaz:
https://doaj.org/article/03bdfdd5c46748bb850a5f89fde63d91
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117078- (2024)
The eye is one of the most vulnerable parts of the human body. There are many kinds of ophthalmic diseases, which are caused by multiple factors. Generally, ophthalmic diseases have the characteristics of complicated etiology and difficult therapy. W
Externí odkaz:
https://doaj.org/article/64e9cab018eb41c0a16effb0457d0f62
Autor:
Jisheng Zhang, Junmei Ye, Albert Altafaj, Maria Cardona, Núria Bahi, Marta Llovera, Xavier Cañas, Stuart A Cook, Joan X Comella, Daniel Sanchis
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17998 (2011)
Mitochondrial dysfunction, caspase activation and caspase-dependent DNA fragmentation are involved in cell damage in many tissues. However, differentiated cardiomyocytes repress the expression of the canonical apoptotic pathway and their death during
Externí odkaz:
https://doaj.org/article/2c71090ab483452891e46a4ee5bb5b5a
Autor:
Weixian Kong, Yue Peng, Caoyu Ji, Zekun Liu, Shuya Gao, Yuexin Zhang, Jiawen Chen, Xie Li, Mengmeng Bao, Yubin Zhang, Qizhou Jiang, Fuqun Wang, Zhe Li, Xiaohong Bian, Junmei Ye
Publikováno v:
Clinical Science. 137:823-841
The present study aims to investigate the role of AKT2 in the pathogenesis of hepatic and cardiac lipotoxicity induced by lipid overload-induced obesity and identify its downstream targets. WT and Akt2 KO mice were fed either normal diet, or high-fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82ff0c7033841d95a5f06ee8276f6b8d
https://doi.org/10.1042/cs20230433
https://doi.org/10.1042/cs20230433
Autor:
Shuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye
Publikováno v:
Clinical Science. 136:1711-1730
Metformin is accepted as a first-line drug for the therapy of Type 2 diabetes (T2D), while its mechanism is still controversial. In the present study, by taking advantage of mouse model of high-fat-diet (HFD)-induced obesity and primary mouse hepatoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f98911fc1c572f1e17ea3054670a1f5
https://doi.org/10.1042/cs20220242
https://doi.org/10.1042/cs20220242
Publikováno v:
Bulletin of Economic Research. 75:348-365
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aeffa9726ba26c214ff27f4aba5aa3a
https://doi.org/10.1111/boer.12359
https://doi.org/10.1111/boer.12359
Autor:
Yue Peng, Qingchen Yang, Shuya Gao, Zekun Liu, Weixian Kong, Xiaohong Bian, Zhe Li, Junmei Ye
Publikováno v:
Biochemical and Biophysical Research Communications. 603:144-152
Pro-inflammatory cytokines play important roles in sepsis-induced cardiac injury. Among various cytokines, the function of Interleukin-6 (IL-6) in the regulation of cardiomyocyte injury remains to be elucidated. This study aimed to investigate whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3462d365efcbd52b8b0b88a746ff6873
https://doi.org/10.1016/j.bbrc.2022.03.013
https://doi.org/10.1016/j.bbrc.2022.03.013
Autor:
Weixian Kong, Yue Peng, Caoyu Ji, Zhe Li, Zekun Liu, Shuya Gao, Yuexin Zhang, Jiawen Chen, Xie Li, Mengmeng Bao, Yubin Zhang, Qizhou Jiang, Ruopu Wang, Fangrong Yan, Xiaohong Bian, Junmei Ye
The AKT family plays key roles in global metabolism. However, the function of different AKT isoforms during obesity-associated hepatic and cardiac injury remained unclear. This study aims to elucidate the role of AKT2 in the pathogenesis of hepatic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd6f02de3aba6eb9f869378dbf5cfbd4
https://doi.org/10.21203/rs.3.rs-2300920/v1
https://doi.org/10.21203/rs.3.rs-2300920/v1
Autor:
Shuya Gao, Qingchen Yang, Yue Peng, Weixian Kong, Zekun Liu, Zhe Li, Jiawen Chen, Mengmeng Bao, Xie Li, Yubin Zhang, Xiaohong Bian, Liang Jin, Hanwen Zhang, Yuexin Zhang, Daniel Sanchis, Fangrong Yan, Junmei Ye
Publikováno v:
Cell Biology and Toxicology.
The sirtuin 6 (SIRT6) participates in regulating glucose and lipid homeostasis. However, the function of SIRT6 in the process of cardiac pathogenesis caused by obesity-associated lipotoxicity remains to be unveiled. This study was designed to elucida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48c959619bca93b368c89fde2fc713e
https://doi.org/10.1007/s10565-022-09735-z
https://doi.org/10.1007/s10565-022-09735-z
Autor:
Miao Chen, Yaoting Li, Fangrong Yan, Junmei Ye, Xingyu Gao, Nan Jiang, Kaidi Zhang, Shuya Gao, Yubin Zhang, Yue Peng, Xiaohong Bian, Daniel Sanchis, Caoyu Ji, Caiping Chen, Qingchen Yang, Zhe Li
Publikováno v:
Clinical Science. 134:2381-2398
Skeletal muscle is responsible for the majority of glucose disposal in the body. Insulin resistance in the skeletal muscle accounts for 85–90% of the impairment of total glucose disposal in patients with type 2 diabetes (T2D). However, the mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ac1feafc1a2d9c5f3c5db2c80021a5
https://doi.org/10.1042/cs20191320
https://doi.org/10.1042/cs20191320