Výsledky vyhledávání - "Junko Sugatani"

Akademický článek

Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells

Autor: Hiroyuki Sonoki, Tomonari Sato, Satoshi Endo, Toshiyuki Matsunaga, Masahiko Yamaguchi, Yasuhiro Yamazaki, Junko Sugatani, Akira Ikari

Publikováno v: Nutrients, Vol 7, Iss 6, Pp 4578-4592 (2015)

Claudin-2 is highly expressed in human lung adenocarcinoma tissues and cells. Knockdown of claudin-2 decreases cell proliferation and migration. Claudin-2 may be a novel target for lung adenocarcinoma. However, there are no physiologically active sub

Externí odkaz: https://doaj.org/article/be46dae96ccb4849aa5d03899cbecbde

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Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells

Autor: Junko Sugatani, Masahiko Yamaguchi, Satoshi Endo, Yukinobu Matsuo, Naoko Fujii, Toshiyuki Matsunaga, Hideki Sakai, Yasuhiro Yamazaki, Akira Ikari

Publikováno v: Journal of Biological Chemistry. 291:24787-24799

Hypotonic stress decreased claudin-1 and -2 expression levels in renal tubular epithelial HK-2 and Madin-Darby canine kidney cells. Here, we examined the regulatory mechanism involved in this decrease. The hypotonicity-induced decrease in claudin exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb2ba7289947ebf638b02252bbf9ed5
https://doi.org/10.1074/jbc.m116.728196

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Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells

Autor: Shun Shimobaba, Yasuhiro Yamazaki, Satoshi Endo, Masahiko Yamaguchi, Tomonari Sato, Hideki Sakai, Saeko Taga, Ryo Watanabe, Junko Sugatani, Toshiyuki Matsunaga, Hiroyuki Sonoki, Akira Ikari

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1848(10):2326-2336

Claudins are tight junctional proteins and comprise a family of over 20 members. Abnormal expression of claudins is reported to be involved in tumor progression. Claudin-2 is highly expressed in lung adenocarcinoma tissues and increases cell prolifer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e44debf7675417f1d756cc0d68b2753

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Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCβ-Dependent GATA-2 in MDCK Cells

Autor: Junko Sugatani, Yasuhiro Yamazaki, Hisayoshi Hayashi, Shinya Hahakabe, Akira Ikari, Toshiyuki Matsunaga, Masahiko Yamaguchi, Naoko Fujii, Satoshi Endo

Publikováno v: Journal of Cellular Physiology. 230:2776-2787

Hyperosmolarity decreases claudin-2 expression in renal tubular epithelial cells, but the molecular mechanism remains undefined. Here, we found that the hyperosmolarity-induced decrease in claudin-2 expression is inhibited by Go6983, a non-selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5089e36b18ef77642c5b08232ea76bc3
https://doi.org/10.1002/jcp.25004

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Involvement of a cyclic adenosine monophosphate–dependent signal in the diet‐induced canalicular trafficking of adenosine triphosphate–binding cassette transporter g5/g8

Autor: Yuzuki Murata, Masahiko Yamaguchi, Kenta Yasui, Ayaka Mori, Junko Sugatani, Akira Ikari, Arisa Suto, Yasuhiro Yamazaki, Takahiro Hashizume

Publikováno v: Hepatology. 62:1215-1226

The adenosine triphosphate–binding cassette (ABC) half-transporters Abcg5 and Abcg8 promote the secretion of neutral sterol into bile. Studies have demonstrated the diet-induced gene expression of these transporters, but the regulation of their tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ddfa48220e3f0500b94c475e52ba49
https://doi.org/10.1002/hep.27914

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Tight Junctional Localization of Claudin-16 Is Regulated by Syntaxin 8 in Renal Tubular Epithelial Cells

Autor: Hideki Sakai, Toru Kimura, Satoshi Endo, Hajime Hasegawa, Akira Ikari, Hisayoshi Hayashi, Junko Sugatani, Yasuhiro Yamazaki, Ayumi Sanada, Toshiyuki Matsunaga, Chie Tonegawa, Masahiko Yamaguchi

Publikováno v: Journal of Biological Chemistry. 289:13112-13123

Claudin-16 (CLDN16) regulates the paracellular reabsorption of Mg(2+) in the thick ascending limb of Henle's loop. However, the mechanism regulating the tight junctional localization of CLDN16 remains unknown. In yeast two-hybrid systems, we found th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cf62a63d04698881c6cad5a92b8014
https://doi.org/10.1074/jbc.m113.541193

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Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation

Autor: Hideki Sakai, Junko Sugatani, Masahiko Yamaguchi, Akira Ikari, Kosuke Atomi, Hisayoshi Hayashi, Yasuhiro Yamazaki

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1833:2617-2627

Claudin-4 is exclusively localized in the tight collecting ducts in the renal tubule. We examined what molecular mechanism is involved in the regulation of claudin-4 expression. In Madin–Darby canine kidney cells, hyperosmolarity increased the expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b379f21cf030f23bb39136db4fc235b
https://doi.org/10.1016/j.bbamcr.2013.06.016

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Antiobese function of platelet‐activating factor: increased adiposity in platelet‐activating factor receptor‐deficient mice with age

Autor: Ryoko Higa, Akira Ikari, Masahiko Yamaguchi, Yoshiki Hattori, Yasuhiro Yamazaki, Takahiro Uchida, Satoshi Ishii, Masao Miwa, Junko Sugatani, Tatsuo Watanabe, Takao Shimizu, Satoshi Sadamitsu, Wataru Sugiyama

Publikováno v: The FASEB Journal. 28:440-452

Platelet-activating factor receptor (PAFR)-deficient mice developed a more severe obese state characterized by higher body mass (~25%) and epididymal fat mass (~55%) with age than that of wild-type (WT) littermates. PAFR-deficient mice did not show c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a2db99bda6b81f95678322c5e28118
https://doi.org/10.1096/fj.13-233262

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A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice

Autor: Masahiro Egi, Toshio Miyase, Kengo Yasuda, Akira Ikari, Taira Sawairi, Masahiko Yamaguchi, Junko Sugatani, Masao Miwa, Takuya Ishihara, Shuji Akai, Yasuhiro Yamazaki, Ryoko Higa, Tensei Matsuyama

Publikováno v: Biochemical Pharmacology. 86:632-644

Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) acetyltransferase is a key enzyme in the biosynthesis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) in inflammatory cells. Substances which inhibit this enzyme are of therapeutic i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b071868ce53d1ee4dabfbf68790f6553
https://doi.org/10.1016/j.bcp.2013.06.021

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Enhancement of cell-cell contact by claudin-4 in renal epithelial madin-darby canine kidney cells

Autor: Yasuhiro Yamazaki, Akira Ikari, Junko Sugatani, Ayumi Takiguchi, Hisayoshi Hayashi, Kosuke Atomi, Jotaro Hirakawa

Publikováno v: Journal of Cellular Biochemistry. 113:499-507

Claudin-4 regulates ion permeability via a paracellular pathway in renal epithelial cells, but its other physiological functions have not been examined. We found that hyperosmotic stress increases claudin-4 expression in Madin-Darby canine kidney cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c84b7cccad8dc5d36b9ff9168792e3a
https://doi.org/10.1002/jcb.23373

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