Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Junko Okano"'
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Bone marrow-derived cells (BMDCs) are heterogeneous populations in which not only pluripotent stem cells, namely, hematopoietic stem cells (HSCs), mesenchymal stem cells (MSC) but also endothelial progenitor cells (EPC) are involved. BMDCs contribute
Externí odkaz:
https://doaj.org/article/243b69cded544e799cad6890b1d6735f
Autor:
Hideto Kojima, Miwako Katagi, Junko Okano, Yuki Nakae, Natsuko Ohashi, Kazunori Fujino, Itsuko Miyazawa, Takahiko Nakagawa
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Despite the growing epidemic worldwide, diabetes is an incurable disease. We have been focusing on why diabetes manifests refractoriness to any therapy. We recently found that abnormal bone marrow-derived cells (BMDCs), namely, Vcam-1+ST-HSC
Externí odkaz:
https://doaj.org/article/23671901db2d4547b23779f640d86201
Autor:
Yuuki Shirai, Junko Okano, Takahiko Nakagawa, Miwako Katagi, Yuki Nakae, Atsuhiro Arakawa, Shinya Koshinuma, Gaku Yamamoto, Hideto Kojima
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Deep skin wounds with periosteal defects, frequently caused by traffic accidents or radical dissection, are refractory. Transplant surgery is frequently performed, but patients are subjected to stress for long operation periods, the sacrific
Externí odkaz:
https://doaj.org/article/38647d5ca48a4c0998eb0a0c92f32d44
Autor:
Junko Okano, MD, PhD, Jun Arata, MD, PhD, Atsuhiro Arakawa, MD, Shuichi Ogino, MD, PhD, Teruyo Yamashita, MD
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 11, Iss 2, p e4812 (2023)
Summary:. Basal cell carcinoma (BCC), which is relatively easy to diagnose in a clinical setting, is the most common malignant tumor in the skin. Conversely, a giant BCC, a tumor beyond 5 cm in diameter, is a rare disease. In particular, a giant BCC
Externí odkaz:
https://doaj.org/article/b120750a4cd64ae88bd28612448c93dd
Autor:
Natsuko Ohashi, Tomoya Terashima, Miwako Katagi, Yuki Nakae, Junko Okano, Yoshihisa Suzuki, Hideto Kojima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) is an intractable neurodegenerative disease. CD68-positive bone marrow (BM)-derived cells (BMDCs) accumulate in the pathological lesion in the SOD1(G93A) ALS mouse model after BM transplantation (BMT). The
Externí odkaz:
https://doaj.org/article/54be9e626a714971ae9b84bc8055e8a3
Autor:
Miwako Katagi, Tomoya Terashima, Natsuko Ohashi, Yuki Nakae, Akane Yamada, Takahiko Nakagawa, Itsuko Miyazawa, Hiroshi Maegawa, Junko Okano, Yoshihisa Suzuki, Kazunori Fujino, Yutaka Eguchi, Hideto Kojima
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Katagi et al. show that abnormal bone marrow-derived cells originated from hematopoietic stem cells (CD106-positive short-term HSCs) aberrantly fuse with neurons to develop diabetic neuropathy. This study suggests that the pathological abnormality is
Externí odkaz:
https://doaj.org/article/e89bf4e21fc54a66a503dcaba1d6baae
Autor:
Junko Okano, Yuki Nakae, Takahiko Nakagawa, Miwako Katagi, Tomoya Terashima, Daisuke Nagakubo, Takashi Nakayama, Osamu Yoshie, Yoshihisa Suzuki, Hideto Kojima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its under
Externí odkaz:
https://doaj.org/article/6af682acd4a34395939e1f2e7783ce9b
Autor:
Hiroshi Takamura, Tomoya Terashima, Kanji Mori, Miwako Katagi, Junko Okano, Yoshihisa Suzuki, Shinji Imai, Hideto Kojima
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 657-665 (2020)
Treating neuropathic pain is a critical clinical issue. Although numerous therapies have been proposed, effective treatments have not been established. Therefore, safe and feasible treatment methods are urgently needed. In this study, we investigated
Externí odkaz:
https://doaj.org/article/12769ee98652454db6e42fd2cc6dd20c
Autor:
Tomoya Terashima, Nobuhiro Ogawa, Toshiyuki Sato, Miwako Katagi, Yuki Nakae, Junko Okano, Hiroshi Maegawa, Hideto Kojima
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 474-483 (2019)
Homing peptides to the spinal cord were identified and isolated using phage display technology. In vivo biopanning was performed by intravenous systemic injection of a phage library to screen specific peptides targeting the spinal cord of mice. Analy
Externí odkaz:
https://doaj.org/article/540f04a72565484f90deef2307f7a4e6
Gene Therapy for Neuropathic Pain through siRNA-IRF5 Gene Delivery with Homing Peptides to Microglia
Autor:
Tomoya Terashima, Nobuhiro Ogawa, Yuki Nakae, Toshiyuki Sato, Miwako Katagi, Junko Okano, Hiroshi Maegawa, Hideto Kojima
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 203-215 (2018)
Astrocyte- and microglia-targeting peptides were identified and isolated using phage display technology. A series of procedures, including three cycles of both in vivo and in vitro biopanning, was performed separately in astrocytes and in M1 or M2 mi
Externí odkaz:
https://doaj.org/article/43472f74063f455186e3da208eeecea2