Effect of geranylated dihydrochalcone from Artocarpus altilis leaves extract on Plasmodium falciparum ultrastructural changes and mitochondrial malate: Quinone oxidoreductase

Autor: Agriana Rosmalina Hidayati, Melinda, Hilkatul Ilmi, Takaya Sakura, Miako Sakaguchi, Junko Ohmori, Endah Dwi Hartuti, Lidya Tumewu, Daniel Ken Inaoka, Mulyadi Tanjung, Eri Yoshida, Fuyuki Tokumasu, Kiyoshi Kita, Mihoko Mori, Kazuyuki Dobashi, Tomoyoshi Nozaki, Din Syafruddin, Achmad Fuad Hafid, Danang Waluyo, Aty Widyawaruyanti

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 21, Iss , Pp 40-50 (2023)

Nearly half of the world's population is at risk of being infected by Plasmodium falciparum, the pathogen of malaria. Increasing resistance to common antimalarial drugs has encouraged investigations to find compounds with different scaffolds. Extract

Externí odkaz: https://doaj.org/article/6b134f392fa14e72bc9716284882d2dc

Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria

Autor: Teruki Honma, Tsuyoshi Sasaki, Emmanuel Oluwadare Balogun, Dan Sato, Junko Ohmori, Madoka Nagahama, Masatsugu Oda, Shigeru Matsuoka, Tomoo Shiba, Kiyoshi Kita, Shigeharu Harada, Masayuki Inoue, Daniel Ken Inaoka

Publikováno v: International Journal of Molecular Sciences
Volume 16
Issue 7
Pages 15287-15308
International Journal of Molecular Sciences, Vol 16, Iss 7, Pp 15287-15308 (2015)

Recent studies on the respiratory chain of Ascaris suum showed that the mitochondrial NADH-fumarate reductase system composed of complex I, rhodoquinone and complex II plays an important role in the anaerobic energy metabolism of adult A. suum. The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cbd1c71bbd2278a2c320dea20a710a
https://doi.org/10.3390/ijms160715287

Novel TK2 mutations as a cause of delayed muscle maturation in mtDNA depletion syndrome

Autor: Hiroshi Suzumura, Satomi Mitsuhashi, Seito Hisamatsu, Osamu Arisaka, Satoru Noguchi, Ishiyama Akihiko, Noriko Sumitomo, Thanes Termglinchan, George Imataka, Masayuki Sasaki, Ikuya Nonaka, Yu-ichi Goto, Nobuyuki Murakami, Junko Ohmori, Ichizo Nishino, Narihiro Minami

Publikováno v: Neurology: Genetics

Recessive mutations in TK2 cause a severe mitochondrial DNA depletion syndrome (MDS),(1) characterized by severe myopathy from early infancy. Recent reports have suggested a wider clinical spectrum including encephalomyopathic form.(1,2) We report a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d409df2832f9b47023b3aa1247dd8b58
https://pubmed.ncbi.nlm.nih.gov/27660820