Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Junko Nagai"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Adverse effects can occur owing to anorexia, which can reduce treatment compliance and worsen the patients overall condition. One such side effect, namely drug-induced taste and smell disorders, reduces patients quality of life. Although ant
Externí odkaz:
https://doaj.org/article/9f3515bb1d434d74b2cc8c37eb0a39bb
Autor:
Junko Nagai, Yoichi Ishikawa
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0260980 (2021)
IntroductionAnticholinergic adverse effects (AEs) are a problem for elderly people. This study aimed to answer the following questions. First, is an analysis of anticholinergic AEs using spontaneous adverse drug event databases possible? Second, what
Externí odkaz:
https://doaj.org/article/ea3eb04f8ac84e88899a3134095477f3
Autor:
Yoshiaki Sugita, Koichi Takao, Yoshihiro Uesawa, Junko Nagai, Yosuke Iijima, Motohiko Sano, Hiroshi Sakagami
Publikováno v:
Medicines, Vol 7, Iss 9, p 50 (2020)
Since many anticancer drugs show severe adverse effects such as mucositis, peripheral neurotoxicity, and extravasation, it was crucial to explore new compounds with much reduced adverse effects. Comprehensive investigation with human malignant and no
Externí odkaz:
https://doaj.org/article/8eb58239e3b147f88380b8bdfe256cd1
Autor:
Yoshihide Usami, Megumi Higuchi, Koji Mizuki, Mizuki Yamamoto, Mao Kanki, Chika Nakasone, Yuya Sugimoto, Makio Shibano, Yoshihiro Uesawa, Junko Nagai, Hiroki Yoneyama, Shinya Harusawa
Publikováno v:
Marine Drugs, Vol 18, Iss 4, p 221 (2020)
Inspired by the significant α-glucosidase inhibitory activities of (+)- and (−)-pericosine E, we herein designed and synthesized 16 analogs of these marine natural products bearing a methoxy group instead of a chlorine atom at C6. Four of these co
Externí odkaz:
https://doaj.org/article/79470c8115fe4f6a838e08e202da2296
Publikováno v:
Medicines, Vol 6, Iss 2, p 45 (2019)
Background: Anticancer drugs often have strong toxicity against tumours and normal cells. Some natural products demonstrate high tumour specificity. We have previously reported the cytotoxic activity and tumour specificity of various chemical compoun
Externí odkaz:
https://doaj.org/article/be09d55041234cf6b5834a285a9dc484
Autor:
Hiroshi Sakagami, Taihei Watanabe, Tomonori Hoshino, Naoto Suda, Kazumasa Mori, Toshikazu Yasui, Naoki Yamauchi, Harutsugu Kashiwagi, Tsuneaki Gomi, Takaaki Oizumi, Junko Nagai, Yoshihiro Uesawa, Koichi Takao, Yoshiaki Sugita
Publikováno v:
Medicines, Vol 6, Iss 1, p 4 (2018)
The present article reviews the research progress of three major polyphenols (tannins, flavonoids and lignin carbohydrate complexes), chromone (backbone structure of flavonoids) and herbal extracts. Chemical modified chromone derivatives showed highl
Externí odkaz:
https://doaj.org/article/55b3cb19f96f4fddbbe52888e9f3343c
Autor:
Yoshiaki Sugita, Koichi Takao, Yoshihiro Uesawa, Akito Tomomura, Mineko Tomomura, Kaori Hoshi, Hiroshi Sakagami, Junko Nagai, Haixia Shi, Kenjiro Bandow
Publikováno v:
Anticancer Research. 40(1):87-95
Background/Aim: Very few studies are available about the biological activity of 3-styrylchromones. Our previous study demonstrated the importance of methoxy group at 6-position of the chromone ring and hydroxyl group at 4’-position of phenyl group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa98c12cdbfc7bd86c9c4932364e081
https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-anticanres.13929
https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-anticanres.13929
Autor:
Koichi Takao, Hiroshi Sakagami, Junko Nagai, Haixia Shi, Kenjiro Bandow, Nao Yoshida, Mineko Tomomura, Natsuko Sezaki, Yoshiaki Sugita, Akito Tomomura, Yoshihiro Uesawa
Publikováno v:
Anticancer Research. 39:6479-6488
BACKGROUND/AIM 4H-1-Benzopyran-4-one (chromone), present in various flavonoids as a backbone structure, has been used for the synthesis of anticancer drugs. The study aimed at investigating the cytotoxicity of eight 2-arylazolylchromones and twelve 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c873f50952c7c592918899592883cd
https://doi.org/10.21873/anticanres.13862
https://doi.org/10.21873/anticanres.13862
Autor:
Yoichi Ishikawa, Junko Nagai
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0260980 (2021)
PLoS ONE, Vol 16, Iss 12, p e0260980 (2021)
Introduction Anticholinergic adverse effects (AEs) are a problem for elderly people. This study aimed to answer the following questions. First, is an analysis of anticholinergic AEs using spontaneous adverse drug event databases possible? Second, wha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6befff2aff700a97399c97a5523283aa
https://pubmed.ncbi.nlm.nih.gov/34855908
https://pubmed.ncbi.nlm.nih.gov/34855908
Autor:
Noriyuki Okudaira, Akito Tomomura, Kana Imanari, Hiroshi Sakagami, Yoshihiro Uesawa, Hidetsugu Wakabayashi, Kenjiro Bandow, Junko Nagai, Mineko Tomomura, Masashi Hashimoto
Publikováno v:
Anticancer Research. 39:3507-3518
Background/Aim: Very few studies of anticancer activity of azulene amides led us to investigate the cytotoxicity of 21 N-alkylazulene-1-carboxamides introduced either with 3-methyl [1-7], 7-isopropyl-3-methyl [8-14] or 2-methoxy group [15-21]. Materi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d29056ca62b8e299e26c36e688b7a3
https://doi.org/10.21873/anticanres.13497
https://doi.org/10.21873/anticanres.13497